5jhw - Revision history

OCA at 18:52, 20 September 2023

2023-09-20T18:52:41Z

←Older revision		Revision as of 18:52, 20 September 2023
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	<StructureSection load='5jhw' size='340' side='right'caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5jhw' size='340' side='right'caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JHW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=FLC:CITRATE+ANION'>FLC</scene~~>, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.35Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ji1\|5ji1]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">GDF11, BMP11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=9606 HUMAN]), FST ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhw OCA], [https://pdbe.org/5jhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jhw RCSB], [https://www.ebi.ac.uk/pdbsum/5jhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhw ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhw OCA], [~~http~~://pdbe.org/5jhw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jhw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jhw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhw ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN]] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. [[http://www.uniprot.org/uniprot/FST_HUMAN FST_HUMAN]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).	+	[https://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Follistatin\|Follistatin]]
	*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]		*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Thompson~~, T B~~]]	+	[[Category: Thompson TB]]
-	[[Category: Walker~~, R G]]~~	+	[[Category: Walker RG]]
-	~~[[Category: Cytokine-signaling protein complex]]~~	+
-	~~[[Category: Follistatin]]~~	+
-	~~[[Category: Gdf11]]~~	+
-	~~[[Category: Ligand]]~~	+
-	~~[[Category: Tgfbeta~~]]	+

OCA at 12:02, 25 December 2019

2019-12-25T12:02:03Z

←Older revision		Revision as of 12:02, 25 December 2019
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	==Crystal Structure of the GDF11:Follistatin 288 complex==		==Crystal Structure of the GDF11:Follistatin 288 complex==
-	<StructureSection load='5jhw' size='340' side='right' caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>	+	<StructureSection load='5jhw' size='340' side='right'caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHW FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHW FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5jhw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jhw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Growth differentiation factor 3D STRUCTURES\|Growth differentiation factor 3D STRUCTURES]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Thompson, T B]]		[[Category: Thompson, T B]]
	[[Category: Walker, R G]]		[[Category: Walker, R G]]

OCA at 12:54, 6 November 2017

2017-11-06T12:54:46Z

←Older revision		Revision as of 12:54, 6 November 2017
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	<StructureSection load='5jhw' size='340' side='right' caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>		<StructureSection load='5jhw' size='340' side='right' caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ji1\|5ji1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ji1\|5ji1]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GDF11, BMP11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), FST ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhw OCA], [http://pdbe.org/5jhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhw RCSB], [http://www.ebi.ac.uk/pdbsum/5jhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhw OCA], [http://pdbe.org/5jhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhw RCSB], [http://www.ebi.ac.uk/pdbsum/5jhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhw ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Thompson, T B]]		[[Category: Thompson, T B]]
	[[Category: Walker, R G]]		[[Category: Walker, R G]]

OCA at 16:21, 22 March 2017

2017-03-22T16:21:32Z

←Older revision		Revision as of 16:21, 22 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jhw is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of the GDF11:Follistatin 288 complex==
		+	<StructureSection load='5jhw' size='340' side='right' caption='[[5jhw]], [[Resolution\|resolution]] 2.35Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jhw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JHW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ji1\|5ji1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jhw OCA], [http://pdbe.org/5jhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jhw RCSB], [http://www.ebi.ac.uk/pdbsum/5jhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jhw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GDF11_HUMAN GDF11_HUMAN]] Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. [[http://www.uniprot.org/uniprot/FST_HUMAN FST_HUMAN]] Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor beta (TGFbeta) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are conflicting studies on the function of GDF11 and whether GDF11 has beneficial effects on age-related dysfunction. To address whether GDF8 and GDF11 are functionally identical, we compared their signaling and structural properties. RESULTS: Here we show that, despite their high similarity, GDF11 is a more potent activator of SMAD2/3 and signals more effectively through the type I activin-like receptor kinase receptors ALK4/5/7 than GDF8. Resolution of the GDF11:FS288 complex, apo-GDF8, and apo-GDF11 crystal structures reveals unique properties of both ligands, specifically in the type I receptor binding site. Lastly, substitution of GDF11 residues into GDF8 confers enhanced activity to GDF8. CONCLUSIONS: These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.

-	~~Authors~~:	+	Structural basis for potency differences between GDF8 and GDF11.,Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB BMC Biol. 2017 Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1. PMID:28257634<ref>PMID:28257634</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jhw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Thompson, T B]]
		+	[[Category: Walker, R G]]
		+	[[Category: Cytokine-signaling protein complex]]
		+	[[Category: Follistatin]]
		+	[[Category: Gdf11]]
		+	[[Category: Ligand]]
		+	[[Category: Tgfbeta]]

OCA at 12:50, 3 October 2016

2016-10-03T12:50:54Z

←Older revision		Revision as of 12:50, 3 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jhw is ON HOLD	+	The entry 5jhw is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 15:26, 15 May 2016

2016-05-15T15:26:09Z

←Older revision		Revision as of 15:26, 15 May 2016
Line 3:		Line 3:
	The entry 5jhw is ON HOLD		The entry 5jhw is ON HOLD

-	Authors: ~~Walker, R.G., Thompson, T.B.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Thompson, T.B]]
-	[[Category: Walker, R.G]]

OCA: Protected "5jhw" [edit=sysop:move=sysop]

2016-05-11T02:05:44Z

Protected "5jhw" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:05, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jhw is ON HOLD Authors: Walker, R.G., Thompson, T.B. Description: Category: Unreleased Structures Category: Thompson, T.B [[Category: Wal...

2016-05-11T02:05:43Z

New page: '''Unreleased structure''' The entry 5jhw is ON HOLD Authors: Walker, R.G., Thompson, T.B. Description: Category: Unreleased Structures Category: Thompson, T.B [[Category: Wal...

New page

'''Unreleased structure'''

The entry 5jhw is ON HOLD

Authors: Walker, R.G., Thompson, T.B.

Description:
[[Category: Unreleased Structures]]
[[Category: Thompson, T.B]]
[[Category: Walker, R.G]]