5jnv - Revision history

OCA at 19:00, 20 September 2023

2023-09-20T19:00:12Z

←Older revision		Revision as of 19:00, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jnv' size='340' side='right'caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5jnv' size='340' side='right'caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JNV FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jnr\|5jnr]]~~, [[~~5jns~~\|~~5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnw\|5jnw~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9913 BOVIN])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnv OCA], [https://pdbe.org/5jnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jnv RCSB], [https://www.ebi.ac.uk/pdbsum/5jnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnv ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Protein~~-~~tyrosine~~-~~phosphatase Protein~~-~~tyrosine~~-~~phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnv OCA], [~~http~~://pdbe.org/5jnv PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jnv RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jnv PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnv ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.	+	[https://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein-tyrosine-phosphatase]]~~	+	[[Category: Aleshin AE]]
-	[[Category: Aleshin~~, A E~~]]	+	[[Category: Bankston L]]
-	[[Category: Bankston, L]]	+	[[Category: Bottini N]]
-	[[Category: Bottini, N]]	+	[[Category: Cadwell G]]
-	[[Category: Cadwell, G]]	+	[[Category: Liddington RC]]
-	[[Category: Liddington~~, R C~~]]	+	[[Category: Stanford SM]]
-	[[Category: Stanford~~, S M]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Lmptp]]~~	+
-	~~[[Category: Lmw-ptp]]~~	+
-	~~[[Category: Protein tyrosine phosphatase~~]]	+

OCA at 12:05, 25 December 2019

2019-12-25T12:05:04Z

←Older revision		Revision as of 12:05, 25 December 2019
Line 1:		Line 1:

	==Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES==		==Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES==
-	<StructureSection load='5jnv' size='340' side='right' caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5jnv' size='340' side='right'caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNV FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNV FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aleshin, A E]]		[[Category: Aleshin, A E]]

OCA at 18:01, 15 November 2017

2017-11-15T18:01:12Z

←Older revision		Revision as of 18:01, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5jnv' size='340' side='right' caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5jnv' size='340' side='right' caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNV FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNV FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jnr\|5jnr]], [[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnw\|5jnw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jnr\|5jnr]], [[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnw\|5jnw]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ACP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnv OCA], [http://pdbe.org/5jnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnv RCSB], [http://www.ebi.ac.uk/pdbsum/5jnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnv ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnv OCA], [http://pdbe.org/5jnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnv RCSB], [http://www.ebi.ac.uk/pdbsum/5jnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnv ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
	[[Category: Protein-tyrosine-phosphatase]]		[[Category: Protein-tyrosine-phosphatase]]
	[[Category: Aleshin, A E]]		[[Category: Aleshin, A E]]

OCA at 04:48, 12 April 2017

2017-04-12T04:48:25Z

←Older revision		Revision as of 04:48, 12 April 2017
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.		[[http://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets. The low-molecular-weight protein tyrosine phosphatase (LMPTP) is a proposed IR phosphatase, yet its role in insulin signaling in vivo has not been defined. Here we show that global and liver-specific LMPTP deletion protects mice from high-fat diet-induced diabetes without affecting body weight. To examine the role of the catalytic activity of LMPTP, we developed a small-molecule inhibitor with a novel uncompetitive mechanism, a unique binding site at the opening of the catalytic pocket, and an exquisite selectivity over other phosphatases. This inhibitor is orally bioavailable, and it increases liver IR phosphorylation in vivo and reverses high-fat diet-induced diabetes. Our findings suggest that LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes.
		+
		+	Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.,Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TD, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N Nat Chem Biol. 2017 Mar 27. doi: 10.1038/nchembio.2344. PMID:28346406<ref>PMID:28346406</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jnv" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:45, 29 March 2017

2017-03-29T13:45:45Z

←Older revision		Revision as of 13:45, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jnv is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of bovine low molecular weight protein tyrosine phosphatase (LMPTP) mutant (W49Y N50E) complexed with HEPES==
-		+	<StructureSection load='5jnv' size='340' side='right' caption='[[5jnv]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Aleshin~~, A.E., ~~Liddington~~, R.C., ~~Bankston~~, L., ~~Cadwell~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jnv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JNV FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of bovine Low~~-~~Molecular Weight Protein Tyrosine Phosphatase (LMPTP) mutant (W49Y~~/~~N50E) complexed with HEPES~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jnr\|5jnr]], [[5jns\|5jns]], [[5jnt\|5jnt]], [[5jnu\|5jnu]], [[5jnw\|5jnw]]</td></tr>
-	[[Category: ~~Liddington~~, ~~R.C~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jnv OCA], [http://pdbe.org/5jnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jnv RCSB], [http://www.ebi.ac.uk/pdbsum/5jnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jnv ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PPAC_BOVIN PPAC_BOVIN]] Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein-tyrosine-phosphatase]]
		+	[[Category: Aleshin, A E]]
		+	[[Category: Bankston, L]]
		+	[[Category: Bottini, N]]
	[[Category: Cadwell, G]]		[[Category: Cadwell, G]]
-	[[Category: ~~Aleshin~~, ~~A.E~~]]	+	[[Category: Liddington, R C]]
-	[[Category: ~~Bankston~~, L]]	+	[[Category: Stanford, S M]]
		+	[[Category: Hydrolase]]
		+	[[Category: Lmptp]]
		+	[[Category: Lmw-ptp]]
		+	[[Category: Protein tyrosine phosphatase]]

OCA at 09:58, 9 March 2017

2017-03-09T09:58:18Z

←Older revision		Revision as of 09:58, 9 March 2017
Line 9:		Line 9:
	[[Category: Liddington, R.C]]		[[Category: Liddington, R.C]]
	[[Category: Cadwell, G]]		[[Category: Cadwell, G]]
-	[[Category: Bankston, L]]
	[[Category: Aleshin, A.E]]		[[Category: Aleshin, A.E]]
		+	[[Category: Bankston, L]]

OCA at 10:55, 18 January 2017

2017-01-18T10:55:35Z

←Older revision		Revision as of 10:55, 18 January 2017
Line 5:		Line 5:
	Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.		Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

-	Description: Crystal ~~Structure~~ of bovine ~~phosphotyrosine phosphatase~~ complexed with HEPES	+	Description: Crystal structure of bovine Low-Molecular Weight Protein Tyrosine Phosphatase (LMPTP) mutant (W49Y/N50E) complexed with HEPES
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Liddington, R.C]]		[[Category: Liddington, R.C]]

OCA at 23:30, 12 July 2016

2016-07-12T23:30:43Z

←Older revision		Revision as of 23:30, 12 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jnv is ON HOLD	+	The entry 5jnv is ON HOLD until Paper Publication

	Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.		Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

OCA: Protected "5jnv" [edit=sysop:move=sysop]

2016-05-15T15:38:47Z

Protected "5jnv" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:38, 15 May 2016

OCA: New page: '''Unreleased structure''' The entry 5jnv is ON HOLD Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G. Description: Crystal Structure of bovine phosphotyrosine phosph...

2016-05-15T15:38:46Z

New page: '''Unreleased structure''' The entry 5jnv is ON HOLD Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G. Description: Crystal Structure of bovine phosphotyrosine phosph...

New page

'''Unreleased structure'''

The entry 5jnv is ON HOLD

Authors: Aleshin, A.E., Liddington, R.C., Bankston, L., Cadwell, G.

Description: Crystal Structure of bovine phosphotyrosine phosphatase complexed with HEPES
[[Category: Unreleased Structures]]
[[Category: Liddington, R.C]]
[[Category: Cadwell, G]]
[[Category: Bankston, L]]
[[Category: Aleshin, A.E]]