5jru - Revision history

OCA at 19:03, 20 September 2023

2023-09-20T19:03:58Z

←Older revision		Revision as of 19:03, 20 September 2023
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	<StructureSection load='5jru' size='340' side='right'caption='[[5jru]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='5jru' size='340' side='right'caption='[[5jru]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jru]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cals4 Cals4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jru]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JRU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.305Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5jrv\|5jrv]], [[5jrx\|5jrx]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273068 CALS4])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jru OCA], [https://pdbe.org/5jru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jru RCSB], [https://www.ebi.ac.uk/pdbsum/5jru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jru ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jru OCA], [~~http~~://pdbe.org/5jru PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jru RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jru PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jru ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8RBX6_CALS4 Q8RBX6_CALS4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cals4~~]]	+	[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bruegger, J]]	+	[[Category: Bruegger J]]
-	[[Category: Hespen, C]]	+	[[Category: Hespen C]]
-	[[Category: Marletta~~, M A~~]]	+	[[Category: Marletta MA]]
-	[[Category: Phillips-Piro~~, C M]]~~	+	[[Category: Phillips-Piro CM]]
-	~~[[Category: Heme-based methyl-accepting chemotaxis protein gas binding signaling protein]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 11:35, 17 June 2020

2020-06-17T11:35:32Z

←Older revision		Revision as of 11:35, 17 June 2020
Line 1:		Line 1:

	==Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus==		==Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus==
-	<StructureSection load='5jru' size='340' side='right' caption='[[5jru]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='5jru' size='340' side='right'caption='[[5jru]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JRU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jru]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cals4 Cals4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JRU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jrv\|5jrv]], [[5jrx\|5jrx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jrv\|5jrv]], [[5jrx\|5jrx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jru OCA], [http://pdbe.org/5jru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jru RCSB], [http://www.ebi.ac.uk/pdbsum/5jru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jru ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tar4, TTE0680 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273068 CALS4])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jru OCA], [http://pdbe.org/5jru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jru RCSB], [http://www.ebi.ac.uk/pdbsum/5jru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jru ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5jru" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jru" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Chemotaxis protein 3D structures\|Chemotaxis protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cals4]]
		+	[[Category: Large Structures]]
	[[Category: Bruegger, J]]		[[Category: Bruegger, J]]
	[[Category: Hespen, C]]		[[Category: Hespen, C]]

OCA at 02:19, 13 July 2016

2016-07-13T02:19:15Z

←Older revision		Revision as of 02:19, 13 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jru is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus==
		+	<StructureSection load='5jru' size='340' side='right' caption='[[5jru]], [[Resolution\|resolution]] 2.31Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jru]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JRU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jrv\|5jrv]], [[5jrx\|5jrx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jru OCA], [http://pdbe.org/5jru PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jru RCSB], [http://www.ebi.ac.uk/pdbsum/5jru PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jru ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acute and specific sensing of diatomic gas molecules is an essential facet of biological signaling. Heme nitric oxide/oxygen binding (H-NOX) proteins are a family of gas sensors found in diverse classes of bacteria and eukaryotes. The most commonly characterized bacterial H-NOX domains are from facultative anaerobes and are activated through a conformational change caused by formation of a 5-coordinate Fe(II)-NO complex. Members of this H-NOX subfamily do not bind O2 and therefore can selectively ligate NO even under aerobic conditions. In contrast, H-NOX domains encoded by obligate anaerobes do form stable 6-coordinate Fe(II)-O2 complexes by utilizing a conserved H-bonding network in the ligand-binding pocket. The biological function of O2-binding H-NOX domains has not been characterized. In this work, the crystal structures of an O2-binding H-NOX domain from the thermophilic obligate anaerobe Caldanaerobacter subterraneus (Cs H-NOX) in the Fe(II)-NO, Fe(II)-CO, and Fe(II)-unliganded states are reported. The Fe(II)-unliganded structure displays a conformational shift distinct from the NO-, CO-, and previously reported O2-coordinated structures. In orthogonal signaling assays using Cs H-NOX and the H-NOX signaling effector histidine kinase from Vibrio cholerae (Vc HnoK), Cs H-NOX regulates Vc HnoK in an O2-dependent manner and requires the H-bonding network to distinguish O2 from other ligands. The crystal structures of Fe(II) unliganded and NO- and CO-bound Cs H-NOX combined with functional assays herein provide the first evidence that H-NOX proteins from obligate anaerobes can serve as O2 sensors.

-	~~Authors: Bruegger, J~~., Hespen, C., Phillips-Piro~~, C.M.~~, Marletta~~, M~~.A.	+	Structural and Functional Evidence Indicates Selective Oxygen Signaling in Caldanaerobacter subterraneus H-NOX.,Hespen CW, Bruegger JJ, Phillips-Piro CM, Marletta MA ACS Chem Biol. 2016 Jun 30. PMID:27328180<ref>PMID:27328180</ref>

-	~~Description: Crystal structure~~ of ~~Fe(II) unliganded H-NOX protein from C~~. ~~subterraneus~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Phillips~~-~~Piro, C.M]]~~	+	<div class="pdbe-citations 5jru" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Marletta, M.A]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bruegger, J]]		[[Category: Bruegger, J]]
	[[Category: Hespen, C]]		[[Category: Hespen, C]]
		+	[[Category: Marletta, M A]]
		+	[[Category: Phillips-Piro, C M]]
		+	[[Category: Heme-based methyl-accepting chemotaxis protein gas binding signaling protein]]
		+	[[Category: Signaling protein]]

OCA: Protected "5jru" [edit=sysop:move=sysop]

2016-06-01T13:45:02Z

Protected "5jru" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:45, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jru is ON HOLD until Paper Publication Authors: Bruegger, J., Hespen, C., Phillips-Piro, C.M., Marletta, M.A. Description: Crystal structure of Fe...

2016-06-01T13:45:01Z

New page: '''Unreleased structure''' The entry 5jru is ON HOLD until Paper Publication Authors: Bruegger, J., Hespen, C., Phillips-Piro, C.M., Marletta, M.A. Description: Crystal structure of Fe...

New page

'''Unreleased structure'''

The entry 5jru is ON HOLD until Paper Publication

Authors: Bruegger, J., Hespen, C., Phillips-Piro, C.M., Marletta, M.A.

Description: Crystal structure of Fe(II) unliganded H-NOX protein from C. subterraneus
[[Category: Unreleased Structures]]
[[Category: Phillips-Piro, C.M]]
[[Category: Marletta, M.A]]
[[Category: Bruegger, J]]
[[Category: Hespen, C]]