5js6 - Revision history

OCA at 19:04, 20 September 2023

2023-09-20T19:04:19Z

←Older revision		Revision as of 19:04, 20 September 2023
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	<StructureSection load='5js6' size='340' side='right'caption='[[5js6]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5js6' size='340' side='right'caption='[[5js6]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5js6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JS6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5js6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JS6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.002Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5en4\|5en4]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5js6 OCA], [~~http~~://pdbe.org/5js6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5js6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5js6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5js6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5js6 OCA], [https://pdbe.org/5js6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5js6 RCSB], [https://www.ebi.ac.uk/pdbsum/5js6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5js6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>	+	[https://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bertoletti, N]]	+	[[Category: Bertoletti N]]
-	[[Category: Heine, A]]	+	[[Category: Heine A]]
-	[[Category: Klebe, G]]	+	[[Category: Klebe G]]
-	[[Category: Marchais-Oberwinkler, S]]	+	[[Category: Marchais-Oberwinkler S]]
-	~~[[Category: Cofactor complex]]~~	+
-	~~[[Category: Hydroxysteroid dehydrogenase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 11:35, 17 June 2020

2020-06-17T11:35:56Z

←Older revision		Revision as of 11:35, 17 June 2020
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	==Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD.==		==Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD.==
-	<StructureSection load='5js6' size='340' side='right' caption='[[5js6]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5js6' size='340' side='right'caption='[[5js6]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5js6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JS6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JS6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5js6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JS6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JS6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5en4\|5en4]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5en4\|5en4]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5js6 OCA], [http://pdbe.org/5js6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5js6 RCSB], [http://www.ebi.ac.uk/pdbsum/5js6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5js6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5js6 OCA], [http://pdbe.org/5js6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5js6 RCSB], [http://www.ebi.ac.uk/pdbsum/5js6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5js6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
-	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]	+	*[[Hydroxysteroid dehydrogenase 3D structures\|Hydroxysteroid dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bertoletti, N]]		[[Category: Bertoletti, N]]
	[[Category: Heine, A]]		[[Category: Heine, A]]

OCA at 03:38, 6 September 2017

2017-09-06T03:38:03Z

←Older revision		Revision as of 03:38, 6 September 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5js6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5js6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hydroxysteroid dehydrogenase\|Hydroxysteroid dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:48, 14 July 2016

2016-07-14T11:48:08Z

←Older revision		Revision as of 11:48, 14 July 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5js6 is ~~ON HOLD~~	+	==Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD.==
		+	<StructureSection load='5js6' size='340' side='right' caption='[[5js6]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5js6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JS6 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5en4\|5en4]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5js6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5js6 OCA], [http://pdbe.org/5js6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5js6 RCSB], [http://www.ebi.ac.uk/pdbsum/5js6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5js6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	17beta-HSD14 is a SDR enzyme able to oxidize estradiol and 5-androstenediol using NAD+. We determined the crystal structure of this human enzyme as the holo form and as ternary complexes with estrone and with the first potent, nonsteroidal inhibitor. The structures reveal a conical, rather large and lipophilic binding site and are the starting point for structure-based inhibitor design. The two natural variants (S205 and T205) were characterized and adopt a similar structure.

-	~~Authors~~: ~~Bertoletti~~, N., ~~Marchais-Oberwinkler~~, S., ~~Heine~~, A., Klebe, G.	+	New Insights into Human 17beta-Hydroxysteroid Dehydrogenase Type 14: First Crystal Structures in Complex with a Steroidal Ligand and with a Potent Nonsteroidal Inhibitor.,Bertoletti N, Braun F, Lepage M, Moller G, Adamski J, Heine A, Klebe G, Marchais-Oberwinkler S J Med Chem. 2016 Jul 12. PMID:27362750<ref>PMID:27362750</ref>

-	~~Description: Crystal structure~~ of ~~17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Marchais~~-~~Oberwinkler, S]]~~	+	<div class="pdbe-citations 5js6" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Klebe, G]]~~	+	== References ==
-	~~[[Category: Heine, A]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bertoletti, N]]		[[Category: Bertoletti, N]]
		+	[[Category: Heine, A]]
		+	[[Category: Klebe, G]]
		+	[[Category: Marchais-Oberwinkler, S]]
		+	[[Category: Cofactor complex]]
		+	[[Category: Hydroxysteroid dehydrogenase]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "5js6" [edit=sysop:move=sysop]

2016-06-01T13:45:51Z

Protected "5js6" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:45, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5js6 is ON HOLD Authors: Bertoletti, N., Marchais-Oberwinkler, S., Heine, A., Klebe, G. Description: Crystal structure of 17beta-hydroxysteroid deh...

2016-06-01T13:45:50Z

New page: '''Unreleased structure''' The entry 5js6 is ON HOLD Authors: Bertoletti, N., Marchais-Oberwinkler, S., Heine, A., Klebe, G. Description: Crystal structure of 17beta-hydroxysteroid deh...

New page

'''Unreleased structure'''

The entry 5js6 is ON HOLD

Authors: Bertoletti, N., Marchais-Oberwinkler, S., Heine, A., Klebe, G.

Description: Crystal structure of 17beta-hydroxysteroid dehydrogenase 14 T205 variant in complex with NAD.
[[Category: Unreleased Structures]]
[[Category: Marchais-Oberwinkler, S]]
[[Category: Klebe, G]]
[[Category: Heine, A]]
[[Category: Bertoletti, N]]