5jv5 - Revision history

OCA at 19:09, 20 September 2023

2023-09-20T19:09:59Z

←Older revision		Revision as of 19:09, 20 September 2023
Line 3:		Line 3:
	<StructureSection load='5jv5' size='340' side='right'caption='[[5jv5]], [[Resolution\|resolution]] 2.73Å' scene=''>		<StructureSection load='5jv5' size='340' side='right'caption='[[5jv5]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jv5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JV5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JV5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=5GP:GUANOSINE~~-~~5-MONOPHOSPHATE'>5GP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.73Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5jsq\|5jsq]], [[5k51\|5k51]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene:]]</b></td><td class~~=~~"sblockDat">HGPRT ([http~~:~~//www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=5702 TRYBB])</td~~></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv5 OCA], [https://pdbe.org/5jv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jv5 RCSB], [https://www.ebi.ac.uk/pdbsum/5jv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv5 ProSAT]</span></td></tr>
-	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv5 OCA], [~~http~~://pdbe.org/5jv5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jv5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jv5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv5 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	+	[https://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 28:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trybb~~]]	+	[[Category: Trypanosoma brucei brucei]]
-	[[Category: Guddat, L]]	+	[[Category: Guddat L]]
-	[[Category: Teran, D]]	+	[[Category: Teran D]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:40, 17 June 2020

2020-06-17T11:40:57Z

←Older revision		Revision as of 11:40, 17 June 2020
Line 1:		Line 1:

	==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Guanosine 5' monophosphate==		==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Guanosine 5' monophosphate==
-	<StructureSection load='5jv5' size='340' side='right' caption='[[5jv5]], [[Resolution\|resolution]] 2.73Å' scene=''>	+	<StructureSection load='5jv5' size='340' side='right'caption='[[5jv5]], [[Resolution\|resolution]] 2.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jv5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV5 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JV5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV5 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JV5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5k51\|5k51]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5k51\|5k51]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGPRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv5 OCA], [http://pdbe.org/5jv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv5 OCA], [http://pdbe.org/5jv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5jv5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jv5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
		+	[[Category: Large Structures]]
		+	[[Category: Trybb]]
	[[Category: Guddat, L]]		[[Category: Guddat, L]]
	[[Category: Teran, D]]		[[Category: Teran, D]]

OCA at 19:51, 9 December 2016

2016-12-09T19:51:33Z

←Older revision		Revision as of 19:51, 9 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jv5 is ~~ON HOLD until Paper~~ Publication	+	==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with Guanosine 5' monophosphate==
		+	<StructureSection load='5jv5' size='340' side='right' caption='[[5jv5]], [[Resolution\|resolution]] 2.73Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jv5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JV5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5k51\|5k51]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jv5 OCA], [http://pdbe.org/5jv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jv5 RCSB], [http://www.ebi.ac.uk/pdbsum/5jv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jv5 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan parasite, Trypanosoma brucei (Tbr). Due to the debilitating side effects of the current therapeutics and the emergence of resistance to these drugs, new medications for this disease need to be developed. One potential new drug target is 6-oxopurine phosphoribosyltransferase (PRT), an enzyme central to the purine salvage pathway and whose activity is critical for the production of the nucleotides (GMP and IMP) required for DNA/RNA synthesis within this protozoan parasite. Here, the first crystal structures of this enzyme have been determined, these in complex with GMP and IMP and with three acyclic nucleoside phosphonate (ANP) inhibitors. The Ki values for GMP and IMP are 30.5 muM and 77 muM, respectively. Two of the ANPs have Ki values considerably lower than for the nucleotides, 2.3 muM (with guanine as base) and 15.8 muM (with hypoxanthine as base). The crystal structures show that when two of the ANPs bind, they induce an unusual conformation change to the loop where the reaction product, pyrophosphate, is expected to bind. This and other structural differences between the Tbr and human enzymes suggest selective inhibitors for the Tbr enzyme can be designed.

-	~~Authors~~:	+	Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.,Teran D, Hockova D, Cesnek M, Zikova A, Naesens L, Keough DT, Guddat LW Sci Rep. 2016 Oct 27;6:35894. doi: 10.1038/srep35894. PMID:27786284<ref>PMID:27786284</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jv5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hypoxanthine phosphoribosyltransferase]]
		+	[[Category: Guddat, L]]
		+	[[Category: Teran, D]]
		+	[[Category: Complex]]
		+	[[Category: Dimer]]
		+	[[Category: Enzyme]]
		+	[[Category: Transferase]]

OCA at 13:09, 20 June 2016

2016-06-20T13:09:16Z

←Older revision		Revision as of 13:09, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jv5 is ON HOLD	+	The entry 5jv5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5jv5" [edit=sysop:move=sysop]

2016-06-01T13:52:39Z

Protected "5jv5" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:52, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jv5 is ON HOLD Authors: Description: Category: Unreleased Structures

2016-06-01T13:52:38Z

New page: '''Unreleased structure''' The entry 5jv5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jv5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]