5jw6 - Revision history

OCA at 19:12, 20 September 2023

2023-09-20T19:12:19Z

←Older revision		Revision as of 19:12, 20 September 2023
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	<StructureSection load='5jw6' size='340' side='right'caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='5jw6' size='340' side='right'caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Aspfu Aspfu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.39Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">AFUA_3G06830 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=330879 ASPFU])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [https://pdbe.org/5jw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [https://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [~~http~~://pdbe.org/5jw6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q4WWR8_ASPFU Q4WWR8_ASPFU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Aspartate-semialdehyde dehydrogenase]]~~	+	[[Category: Aspergillus fumigatus Af293]]
-	~~[[Category: Aspfu~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dahal~~, G P~~]]	+	[[Category: Dahal GP]]
-	[[Category: Viola~~, R E]]~~	+	[[Category: Viola RE]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 16:24, 11 December 2019

2019-12-11T16:24:13Z

←Older revision		Revision as of 16:24, 11 December 2019
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	==Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus==		==Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus==
-	<StructureSection load='5jw6' size='340' side='right' caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>	+	<StructureSection load='5jw6' size='340' side='right'caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]	+	*[[Aspartate-semialdehyde dehydrogenase 3D structures\|Aspartate-semialdehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
	[[Category: Aspfu]]		[[Category: Aspfu]]
		+	[[Category: Large Structures]]
	[[Category: Dahal, G P]]		[[Category: Dahal, G P]]
	[[Category: Viola, R E]]		[[Category: Viola, R E]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 06:23, 18 April 2018

2018-04-18T06:23:27Z

←Older revision		Revision as of 06:23, 18 April 2018
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	<StructureSection load='5jw6' size='340' side='right' caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>		<StructureSection load='5jw6' size='340' side='right' caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">AFUA_3G06830 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [http://pdbe.org/5jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [http://pdbe.org/5jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aspartate-semialdehyde dehydrogenase (ASADH) functions at a critical junction in the aspartate biosynthetic pathway and represents a validated target for antimicrobial drug design. This enzyme catalyzes the NADPH-dependent reductive dephosphorylation of beta-aspartyl phosphate to produce the key intermediate aspartate semialdehyde. The absence of this entire pathway in humans and other mammals will allow the selective targeting of pathogenic microorganisms for antimicrobial development. Here, the X-ray structure of a new form of ASADH from the pathogenic fungal species Aspergillus fumigatus has been determined. The overall structure of this enzyme is similar to those of its bacterial orthologs, but there are some critical differences both in biological assembly and in secondary-structural features that can potentially be exploited for the development of species-selective drugs with selective toxicity against infectious fungal organisms.
		+
		+	Structure of a fungal form of aspartate-semialdehyde dehydrogenase from Aspergillus fumigatus.,Dahal GP, Viola RE Acta Crystallogr F Struct Biol Commun. 2017 Jan 1;73(Pt 1):36-44. doi:, 10.1107/S2053230X16020070. Epub 2017 Jan 1. PMID:28045392<ref>PMID:28045392</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5jw6" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]		*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Aspartate-semialdehyde dehydrogenase]]		[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Aspfu]]
	[[Category: Dahal, G P]]		[[Category: Dahal, G P]]
	[[Category: Viola, R E]]		[[Category: Viola, R E]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]

OCA at 07:26, 6 October 2017

2017-10-06T07:26:32Z

←Older revision		Revision as of 07:26, 6 October 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [http://pdbe.org/5jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [http://pdbe.org/5jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>
	</table>		</table>
		+
		+	==See Also==
		+	*[[Aspartate-semialdehyde dehydrogenase\|Aspartate-semialdehyde dehydrogenase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 16:28, 18 January 2017

2017-01-18T16:28:52Z

←Older revision		Revision as of 16:28, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jw6 is ~~ON HOLD until May 11 2018~~	+	==Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus==
-		+	<StructureSection load='5jw6' size='340' side='right' caption='[[5jw6]], [[Resolution\|resolution]] 2.39Å' scene=''>
-	~~Authors~~: ~~Dahal~~, G.P., ~~Viola~~, R.E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5jw6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JW6 FirstGlance]. <br>
-	~~Description: Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span></td></tr>
-	[[Category: Dahal, G.P]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jw6 OCA], [http://pdbe.org/5jw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5jw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jw6 ProSAT]</span></td></tr>
-	[[Category: Viola, R.E]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Aspartate-semialdehyde dehydrogenase]]
		+	[[Category: Dahal, G P]]
		+	[[Category: Viola, R E]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]

OCA: Protected "5jw6" [edit=sysop:move=sysop]

2016-06-01T13:56:01Z

Protected "5jw6" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:56, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jw6 is ON HOLD until May 11 2018 Authors: Dahal, G.P., Viola, R.E. Description: Cystal structure of aspartate semialdehyde dehydrogenase from Aspe...

2016-06-01T13:55:59Z

New page: '''Unreleased structure''' The entry 5jw6 is ON HOLD until May 11 2018 Authors: Dahal, G.P., Viola, R.E. Description: Cystal structure of aspartate semialdehyde dehydrogenase from Aspe...

New page

'''Unreleased structure'''

The entry 5jw6 is ON HOLD until May 11 2018

Authors: Dahal, G.P., Viola, R.E.

Description: Cystal structure of aspartate semialdehyde dehydrogenase from Aspergillus fumigatus
[[Category: Unreleased Structures]]
[[Category: Dahal, G.P]]
[[Category: Viola, R.E]]