5jyc - Revision history

OCA at 09:49, 27 September 2023

2023-09-27T09:49:58Z

←Older revision		Revision as of 09:49, 27 September 2023
Line 3:		Line 3:
	<StructureSection load='5jyc' size='340' side='right'caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5jyc' size='340' side='right'caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pseab Pseab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_UCBPP-PA14 Pseudomonas aeruginosa UCBPP-PA14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA14_26090 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [https://pdbe.org/5jyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [https://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [https://pdbe.org/5jyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [https://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2ZD27_PSEAB A0A0H2ZD27_PSEAB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseab~~]]	+	[[Category: Pseudomonas aeruginosa UCBPP-PA14]]
-	[[Category: Hvorecny~~, K L~~]]	+	[[Category: Hvorecny KL]]
-	[[Category: Madden~~, D R]]~~	+	[[Category: Madden DR]]
-	~~[[Category: Epoxide hydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydroxyalkyl-enzyme intermediate~~]]	+

OCA at 10:11, 13 April 2022

2022-04-13T10:11:42Z

←Older revision		Revision as of 10:11, 13 April 2022
Line 3:		Line 3:
	<StructureSection load='5jyc' size='340' side='right'caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5jyc' size='340' side='right'caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pseab Pseab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JYC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseab Pseab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA14_26090 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA14_26090 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [~~http~~://pdbe.org/5jyc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [https://pdbe.org/5jyc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [https://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:10, 25 June 2020

2020-06-25T09:10:44Z

←Older revision		Revision as of 09:10, 25 June 2020
Line 1:		Line 1:

	==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate==		==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate==
-	<StructureSection load='5jyc' size='340' side='right' caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5jyc' size='340' side='right'caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JYC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseab Pseab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JYC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [http://pdbe.org/5jyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [http://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PA14_26090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208963 PSEAB])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [http://pdbe.org/5jyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [http://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5jyc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5jyc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[CFTR inhibitory factor\|CFTR inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseab]]
	[[Category: Hvorecny, K L]]		[[Category: Hvorecny, K L]]
	[[Category: Madden, D R]]		[[Category: Madden, D R]]

OCA at 07:27, 18 January 2017

2017-01-18T07:27:11Z

←Older revision		Revision as of 07:27, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5jyc is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted 14,15-EET hydrolysis intermediate==
		+	<StructureSection load='5jyc' size='340' side='right' caption='[[5jyc]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jyc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EET:(5~{Z},11~{Z},14~{R},15~{R})-14,15-BIS(OXIDANYL)ICOSA-5,8,11-TRIENOIC+ACID'>EET</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jyc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jyc OCA], [http://pdbe.org/5jyc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jyc RCSB], [http://www.ebi.ac.uk/pdbsum/5jyc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jyc ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recurrent Pseudomonas aeruginosa infections coupled with robust, damaging neutrophilic inflammation characterize the chronic lung disease cystic fibrosis (CF). The proresolving lipid mediator, 15-epi lipoxin A4 (15-epi LXA4), plays a critical role in limiting neutrophil activation and tissue inflammation, thus promoting the return to tissue homeostasis. Here, we show that a secreted P. aeruginosa epoxide hydrolase, cystic fibrosis transmembrane conductance regulator inhibitory factor (Cif), can disrupt 15-epi LXA4 transcellular biosynthesis and function. In the airway, 15-epi LXA4 production is stimulated by the epithelial-derived eicosanoid 14,15-epoxyeicosatrienoic acid (14,15-EET). Cif sabotages the production of 15-epi LXA4 by rapidly hydrolyzing 14,15-EET into its cognate diol, eliminating a proresolving signal that potently suppresses IL-8-driven neutrophil transepithelial migration in vitro. Retrospective analyses of samples from patients with CF supported the translational relevance of these preclinical findings. Elevated levels of Cif in bronchoalveolar lavage fluid were correlated with lower levels of 15-epi LXA4, increased IL-8 concentrations, and impaired lung function. Together, these findings provide structural, biochemical, and immunological evidence that the bacterial epoxide hydrolase Cif disrupts resolution pathways during bacterial lung infections. The data also suggest that Cif contributes to sustained pulmonary inflammation and associated loss of lung function in patients with CF.

-	~~Authors~~:	+	Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.,Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi:, 10.1073/pnas.1610242114. Epub 2016 Dec 15. PMID:27980032<ref>PMID:27980032</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5jyc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hvorecny, K L]]
		+	[[Category: Madden, D R]]
		+	[[Category: Epoxide hydrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydroxyalkyl-enzyme intermediate]]

OCA at 08:46, 14 July 2016

2016-07-14T08:46:43Z

←Older revision		Revision as of 08:46, 14 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jyc is ON HOLD	+	The entry 5jyc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5jyc" [edit=sysop:move=sysop]

2016-06-01T14:02:52Z

Protected "5jyc" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:02, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jyc is ON HOLD Authors: Description: Category: Unreleased Structures

2016-06-01T14:02:51Z

New page: '''Unreleased structure''' The entry 5jyc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5jyc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]