5jys - Revision history

OCA at 19:15, 20 September 2023

2023-09-20T19:15:43Z

←Older revision		Revision as of 19:15, 20 September 2023
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	<StructureSection load='5jys' size='340' side='right'caption='[[5jys]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5jys' size='340' side='right'caption='[[5jys]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jys]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jys]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JYS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.901Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ete\|5ete]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">PRY1, YJL079C, J1022 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jys OCA], [https://pdbe.org/5jys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jys RCSB], [https://www.ebi.ac.uk/pdbsum/5jys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jys ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5jys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jys OCA], [~~http~~://pdbe.org/5jys PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5jys RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5jys PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5jys ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PRY1_YEAST PRY1_YEAST]] Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.<ref>PMID:23027975</ref>	+	[https://www.uniprot.org/uniprot/PRY1_YEAST PRY1_YEAST] Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.<ref>PMID:23027975</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Baker's yeast]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Asojo, O A~~]]	+	[[Category: Saccharomyces cerevisiae S288C]]
-	[[Category: ~~Cap protein]]~~	+	[[Category: Asojo OA]]
-	~~[[Category: Transport protein~~]]	+

OCA at 09:11, 25 June 2020

2020-06-25T09:11:17Z

←Older revision		Revision as of 09:11, 25 June 2020
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	==Pry1 CAP domain==		==Pry1 CAP domain==
-	<StructureSection load='5jys' size='340' side='right' caption='[[5jys]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5jys' size='340' side='right'caption='[[5jys]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5jys]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5jys]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JYS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ete\|5ete]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ete\|5ete]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5jys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jys OCA], [http://pdbe.org/5jys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jys RCSB], [http://www.ebi.ac.uk/pdbsum/5jys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jys ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRY1, YJL079C, J1022 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5jys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jys OCA], [http://pdbe.org/5jys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jys RCSB], [http://www.ebi.ac.uk/pdbsum/5jys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jys ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Baker's yeast]]
		+	[[Category: Large Structures]]
	[[Category: Asojo, O A]]		[[Category: Asojo, O A]]
	[[Category: Cap protein]]		[[Category: Cap protein]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 15:18, 26 July 2016

2016-07-26T15:18:50Z

←Older revision		Revision as of 15:18, 26 July 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5jys is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Pry1 CAP domain==
		+	<StructureSection load='5jys' size='340' side='right' caption='[[5jys]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5jys]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JYS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ete\|5ete]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jys OCA], [http://pdbe.org/5jys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jys RCSB], [http://www.ebi.ac.uk/pdbsum/5jys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jys ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PRY1_YEAST PRY1_YEAST]] Secreted protein required for efficient export of lipids such as acetylated sterols. Acts in detoxification of hydrophobic compounds.<ref>PMID:23027975</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The production, crystal structure, and functional characterization of the C-terminal cysteine-rich secretory protein/antigen 5/pathogenesis related-1 (CAP) domain of pathogen-related yeast protein-1 (Pry1) from Saccharomyces cerevisiae is presented. The CAP domain of Pry1 (Pry1CAP) is functional in vivo as its expression restores cholesterol export to yeast mutants lacking endogenous Pry1 and Pry2. Recombinant Pry1CAP forms dimers in solution, is sufficient for in vitro cholesterol binding, and has comparable binding properties as full-length Pry1. Two crystal structures of Pry1CAP are reported, one with Mg(2+) coordinated to the conserved CAP tetrad (His208, Glu215, Glu233 and His250) in spacegroup I41 and the other without divalent cations in spacegroup P6122. The latter structure contains four 1,4-dioxane molecules from the crystallization solution, one of which sits in the cholesterol binding site. Both structures reveal that the divalent cation and cholesterol binding sites are connected upon dimerization, providing a structural basis for the observed Mg(2+)-dependent sterol binding by Pry1.

-	~~Authors: Asojo, O~~.A.	+	Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein.,Darwiche R, Kelleher A, Hudspeth EM, Schneiter R, Asojo OA Sci Rep. 2016 Jun 27;6:28838. doi: 10.1038/srep28838. PMID:27344972<ref>PMID:27344972</ref>

-	~~Description~~: ~~Pry1 CAP domain~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Asojo, O.A~~]]	+	<div class="pdbe-citations 5jys" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Asojo, O A]]
		+	[[Category: Cap protein]]
		+	[[Category: Transport protein]]

OCA at 13:15, 20 June 2016

2016-06-20T13:15:53Z

←Older revision		Revision as of 13:15, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5jys is ON HOLD	+	The entry 5jys is ON HOLD until Paper Publication

	Authors: Asojo, O.A.		Authors: Asojo, O.A.

OCA: Protected "5jys" [edit=sysop:move=sysop]

2016-06-01T14:03:56Z

Protected "5jys" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:03, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5jys is ON HOLD Authors: Asojo, O.A. Description: Pry1 CAP domain Category: Unreleased Structures Category: Asojo, O.A

2016-06-01T14:03:55Z

New page: '''Unreleased structure''' The entry 5jys is ON HOLD Authors: Asojo, O.A. Description: Pry1 CAP domain Category: Unreleased Structures Category: Asojo, O.A

New page

'''Unreleased structure'''

The entry 5jys is ON HOLD

Authors: Asojo, O.A.

Description: Pry1 CAP domain
[[Category: Unreleased Structures]]
[[Category: Asojo, O.A]]