5k51 - Revision history

OCA at 09:51, 27 September 2023

2023-09-27T09:51:43Z

←Older revision		Revision as of 09:51, 27 September 2023
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	<StructureSection load='5k51' size='340' side='right'caption='[[5k51]], [[Resolution\|resolution]] 2.96Å' scene=''>		<StructureSection load='5k51' size='340' side='right'caption='[[5k51]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k51]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Trybb Trybb~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K51 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5K51 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k51]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5K51 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=6QD:5~~-~~(6-OXIDANYLIDENE-3~{H}-PURIN-9-YL)PENTYLPHOSPHONIC+ACID'>6QD</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.956Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]]~~, [[~~5jv5~~\|~~5jv5]], [[5kam\|5kam]], [[5kap\|5kap~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QD:5-(6-OXIDANYLIDENE-3~{H}-PURIN-9-YL)PENTYLPHOSPHONIC+ACID'>6QD</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HGPRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~5702 TRYBB])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k51 OCA], [https://pdbe.org/5k51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5k51 RCSB], [https://www.ebi.ac.uk/pdbsum/5k51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5k51 ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k51 OCA], [~~http~~://pdbe.org/5k51 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5k51 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5k51 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5k51 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).	+	[https://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Trybb~~]]	+	[[Category: Trypanosoma brucei brucei]]
-	[[Category: Guddat, L]]	+	[[Category: Guddat L]]
-	[[Category: Teran, D]]	+	[[Category: Teran D]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Enzyme]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 09:19, 25 June 2020

2020-06-25T09:19:03Z

←Older revision		Revision as of 09:19, 25 June 2020
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	==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine==		==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine==
-	<StructureSection load='5k51' size='340' side='right' caption='[[5k51]], [[Resolution\|resolution]] 2.96Å' scene=''>	+	<StructureSection load='5k51' size='340' side='right'caption='[[5k51]], [[Resolution\|resolution]] 2.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5k51]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K51 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5K51 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5k51]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K51 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5K51 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6QD:5-(6-OXIDANYLIDENE-3~{H}-PURIN-9-YL)PENTYLPHOSPHONIC+ACID'>6QD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6QD:5-(6-OXIDANYLIDENE-3~{H}-PURIN-9-YL)PENTYLPHOSPHONIC+ACID'>6QD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5jv5\|5jv5]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5jv5\|5jv5]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HGPRT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k51 OCA], [http://pdbe.org/5k51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k51 RCSB], [http://www.ebi.ac.uk/pdbsum/5k51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k51 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k51 OCA], [http://pdbe.org/5k51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k51 RCSB], [http://www.ebi.ac.uk/pdbsum/5k51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k51 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5k51" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5k51" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phosphoribosyltransferase 3D structures\|Phosphoribosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Hypoxanthine phosphoribosyltransferase]]		[[Category: Hypoxanthine phosphoribosyltransferase]]
		+	[[Category: Large Structures]]
		+	[[Category: Trybb]]
	[[Category: Guddat, L]]		[[Category: Guddat, L]]
	[[Category: Teran, D]]		[[Category: Teran, D]]

OCA at 19:52, 9 December 2016

2016-12-09T19:52:07Z

←Older revision		Revision as of 19:52, 9 December 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5k51 is ~~ON HOLD until Paper~~ Publication	+	==Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine==
		+	<StructureSection load='5k51' size='340' side='right' caption='[[5k51]], [[Resolution\|resolution]] 2.96Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5k51]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5K51 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5K51 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6QD:5-(6-OXIDANYLIDENE-3~{H}-PURIN-9-YL)PENTYLPHOSPHONIC+ACID'>6QD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5jsq\|5jsq]], [[5jv5\|5jv5]], [[5kam\|5kam]], [[5kap\|5kap]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hypoxanthine_phosphoribosyltransferase Hypoxanthine phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.8 2.4.2.8] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5k51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5k51 OCA], [http://pdbe.org/5k51 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5k51 RCSB], [http://www.ebi.ac.uk/pdbsum/5k51 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5k51 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HPRT_TRYBB HPRT_TRYBB]] Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Human African Trypanosomiasis (HAT) is a life-threatening infectious disease caused by the protozoan parasite, Trypanosoma brucei (Tbr). Due to the debilitating side effects of the current therapeutics and the emergence of resistance to these drugs, new medications for this disease need to be developed. One potential new drug target is 6-oxopurine phosphoribosyltransferase (PRT), an enzyme central to the purine salvage pathway and whose activity is critical for the production of the nucleotides (GMP and IMP) required for DNA/RNA synthesis within this protozoan parasite. Here, the first crystal structures of this enzyme have been determined, these in complex with GMP and IMP and with three acyclic nucleoside phosphonate (ANP) inhibitors. The Ki values for GMP and IMP are 30.5 muM and 77 muM, respectively. Two of the ANPs have Ki values considerably lower than for the nucleotides, 2.3 muM (with guanine as base) and 15.8 muM (with hypoxanthine as base). The crystal structures show that when two of the ANPs bind, they induce an unusual conformation change to the loop where the reaction product, pyrophosphate, is expected to bind. This and other structural differences between the Tbr and human enzymes suggest selective inhibitors for the Tbr enzyme can be designed.

-	~~Authors:~~ Teran, D., ~~Guddat~~, L.	+	Crystal structures and inhibition of Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase.,Teran D, Hockova D, Cesnek M, Zikova A, Naesens L, Keough DT, Guddat LW Sci Rep. 2016 Oct 27;6:35894. doi: 10.1038/srep35894. PMID:27786284<ref>PMID:27786284</ref>

-	~~Description: Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with~~ a 9-[5-~~(phosphonoheptyl]hypoxanthine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5k51" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Hypoxanthine phosphoribosyltransferase]]
	[[Category: Guddat, L]]		[[Category: Guddat, L]]
	[[Category: Teran, D]]		[[Category: Teran, D]]
		+	[[Category: Complex]]
		+	[[Category: Dimer]]
		+	[[Category: Enzyme]]
		+	[[Category: Inhibitor]]
		+	[[Category: Transferase]]

OCA at 13:47, 9 September 2016

2016-09-09T13:47:44Z

←Older revision		Revision as of 13:47, 9 September 2016
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	Authors: Teran, D., Guddat, L.		Authors: Teran, D., Guddat, L.

-	Description: Trypanosome brucei Hypoxanthine-guanine~~-xanthine~~ phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine	+	Description: Trypanosome brucei Hypoxanthine-guanine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Guddat, L]]		[[Category: Guddat, L]]
	[[Category: Teran, D]]		[[Category: Teran, D]]

OCA at 13:26, 20 June 2016

2016-06-20T13:26:27Z

←Older revision		Revision as of 13:26, 20 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5k51 is ON HOLD	+	The entry 5k51 is ON HOLD until Paper Publication

	Authors: Teran, D., Guddat, L.		Authors: Teran, D., Guddat, L.

OCA: Protected "5k51" [edit=sysop:move=sysop]

2016-06-01T14:20:10Z

Protected "5k51" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:20, 1 June 2016

OCA: New page: '''Unreleased structure''' The entry 5k51 is ON HOLD Authors: Teran, D., Guddat, L. Description: Trypanosome brucei Hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex wi...

2016-06-01T14:20:08Z

New page: '''Unreleased structure''' The entry 5k51 is ON HOLD Authors: Teran, D., Guddat, L. Description: Trypanosome brucei Hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex wi...

New page

'''Unreleased structure'''

The entry 5k51 is ON HOLD

Authors: Teran, D., Guddat, L.

Description: Trypanosome brucei Hypoxanthine-guanine-xanthine phosphoribosyltranferase in complex with a 9-[5-(phosphonoheptyl]hypoxanthine
[[Category: Unreleased Structures]]
[[Category: Guddat, L]]
[[Category: Teran, D]]