5kjs - Revision history

OCA at 10:47, 27 September 2023

2023-09-27T10:47:45Z

←Older revision		Revision as of 10:47, 27 September 2023
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	<StructureSection load='5kjs' size='340' side='right'caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5kjs' size='340' side='right'caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KJS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KJS FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.203Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kjt\|5kjt]]~~, [[~~5kju~~\|~~5kju~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>HST, HCT, At5g48930, K19E20.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~3702 ARATH])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjs OCA], [https://pdbe.org/5kjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kjs RCSB], [https://www.ebi.ac.uk/pdbsum/5kjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjs ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[http://en.wikipedia.org/wiki/Shikimate_O-hydroxycinnamoyltransferase Shikimate O-hydroxycinnamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.133 2.3.1.133] </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjs OCA], [~~http~~://pdbe.org/5kjs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kjs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kjs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjs ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HST_ARATH HST_ARATH]] Acyltransferase involved in the biosynthesis of lignin. Accepts caffeoyl-CoA and p-coumaroyl-CoA as substrates and transfers the acyl group on both shikimate and quinate acceptors.<ref>PMID:15161961</ref>	+	[https://www.uniprot.org/uniprot/HST_ARATH HST_ARATH] Acyltransferase involved in the biosynthesis of lignin. Accepts caffeoyl-CoA and p-coumaroyl-CoA as substrates and transfers the acyl group on both shikimate and quinate acceptors.<ref>PMID:15161961</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Arath~~]]	+	[[Category: Arabidopsis thaliana]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Shikimate O-hydroxycinnamoyltransferase]]~~	+	[[Category: Chiang YC]]
-	[[Category: Chiang~~, Y C~~]]	+	[[Category: Levsh O]]
-	[[Category: Levsh, O]]	+	[[Category: Noel JP]]
-	[[Category: Noel~~, J P~~]]	+	[[Category: Tung C]]
-	[[Category: Tung, C]]	+	[[Category: Wang Y]]
-	[[Category: Wang, Y]]	+	[[Category: Weng JK]]
-	[[Category: Weng~~, J K]]~~	+
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Bahd]]~~	+
-	~~[[Category: Phenylpropanoid metabolism]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:26, 20 November 2019

2019-11-20T16:26:13Z

←Older revision		Revision as of 16:26, 20 November 2019
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	==Crystal Structure of Arabidopsis thaliana HCT==		==Crystal Structure of Arabidopsis thaliana HCT==
-	<StructureSection load='5kjs' size='340' side='right' caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5kjs' size='340' side='right'caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJS FirstGlance]. <br>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Arath]]		[[Category: Arath]]
		+	[[Category: Large Structures]]
	[[Category: Shikimate O-hydroxycinnamoyltransferase]]		[[Category: Shikimate O-hydroxycinnamoyltransferase]]
	[[Category: Chiang, Y C]]		[[Category: Chiang, Y C]]

OCA at 18:21, 15 November 2017

2017-11-15T18:21:59Z

←Older revision		Revision as of 18:21, 15 November 2017
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	<StructureSection load='5kjs' size='340' side='right' caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5kjs' size='340' side='right' caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJS FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kjt\|5kjt]], [[5kju\|5kju]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kjt\|5kjt]], [[5kju\|5kju]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HST, HCT, At5g48930, K19E20.4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_O-hydroxycinnamoyltransferase Shikimate O-hydroxycinnamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.133 2.3.1.133] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_O-hydroxycinnamoyltransferase Shikimate O-hydroxycinnamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.133 2.3.1.133] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjs OCA], [http://pdbe.org/5kjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kjs RCSB], [http://www.ebi.ac.uk/pdbsum/5kjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjs OCA], [http://pdbe.org/5kjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kjs RCSB], [http://www.ebi.ac.uk/pdbsum/5kjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjs ProSAT]</span></td></tr>
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Arath]]
	[[Category: Shikimate O-hydroxycinnamoyltransferase]]		[[Category: Shikimate O-hydroxycinnamoyltransferase]]
	[[Category: Chiang, Y C]]		[[Category: Chiang, Y C]]

OCA at 03:38, 10 December 2016

2016-12-10T03:38:24Z

←Older revision		Revision as of 03:38, 10 December 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HST_ARATH HST_ARATH]] Acyltransferase involved in the biosynthesis of lignin. Accepts caffeoyl-CoA and p-coumaroyl-CoA as substrates and transfers the acyl group on both shikimate and quinate acceptors.<ref>PMID:15161961</ref>		[[http://www.uniprot.org/uniprot/HST_ARATH HST_ARATH]] Acyltransferase involved in the biosynthesis of lignin. Accepts caffeoyl-CoA and p-coumaroyl-CoA as substrates and transfers the acyl group on both shikimate and quinate acceptors.<ref>PMID:15161961</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase (HCT) is an essential acyltransferase that mediates flux through plant phenylpropanoid metabolism by catalyzing a reaction between p-coumaroyl-CoA and shikimate, yet it also exhibits broad substrate permissiveness in vitro. How do enzymes like HCT avoid functional derailment by cellular metabolites that qualify as non-native substrates? Here, we combine X-ray crystallography and molecular dynamics to reveal distinct dynamic modes of HCT under native and non-native catalysis. We find that essential electrostatic and hydrogen-bonding interactions between the ligand and active site residues, permitted by active site plasticity, are elicited more effectively by shikimate than by other non-native substrates. This work provides a structural basis for how dynamic conformational states of HCT favor native over non-native catalysis by reducing the number of futile encounters between the enzyme and shikimate.
		+
		+	Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase.,Levsh O, Chiang YC, Tung CF, Noel JP, Wang Y, Weng JK Biochemistry. 2016 Nov 2. PMID:27805809<ref>PMID:27805809</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5kjs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:29, 2 November 2016

2016-11-02T18:29:11Z

←Older revision		Revision as of 18:29, 2 November 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kjs is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Crystal Structure of Arabidopsis thaliana HCT==
-		+	<StructureSection load='5kjs' size='340' side='right' caption='[[5kjs]], [[Resolution\|resolution]] 2.20Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kjs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KJS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kjt\|5kjt]], [[5kju\|5kju]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Shikimate_O-hydroxycinnamoyltransferase Shikimate O-hydroxycinnamoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.133 2.3.1.133] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kjs OCA], [http://pdbe.org/5kjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kjs RCSB], [http://www.ebi.ac.uk/pdbsum/5kjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kjs ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HST_ARATH HST_ARATH]] Acyltransferase involved in the biosynthesis of lignin. Accepts caffeoyl-CoA and p-coumaroyl-CoA as substrates and transfers the acyl group on both shikimate and quinate acceptors.<ref>PMID:15161961</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Shikimate O-hydroxycinnamoyltransferase]]
		+	[[Category: Chiang, Y C]]
		+	[[Category: Levsh, O]]
		+	[[Category: Noel, J P]]
		+	[[Category: Tung, C]]
		+	[[Category: Wang, Y]]
		+	[[Category: Weng, J K]]
		+	[[Category: Acyltransferase]]
		+	[[Category: Bahd]]
		+	[[Category: Phenylpropanoid metabolism]]
		+	[[Category: Transferase]]

OCA at 12:28, 26 July 2016

2016-07-26T12:28:44Z

←Older revision		Revision as of 12:28, 26 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kjs is ON HOLD	+	The entry 5kjs is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5kjs" [edit=sysop:move=sysop]

2016-07-13T00:26:20Z

Protected "5kjs" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:26, 13 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kjs is ON HOLD Authors: Description: Category: Unreleased Structures

2016-07-13T00:26:18Z

New page: '''Unreleased structure''' The entry 5kjs is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5kjs is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]