5kqa - Revision history

OCA at 10:51, 27 September 2023

2023-09-27T10:51:28Z

←Older revision		Revision as of 10:51, 27 September 2023
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	<StructureSection load='5kqa' size='340' side='right'caption='[[5kqa]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='5kqa' size='340' side='right'caption='[[5kqa]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kqa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Polygonaceae Polygonaceae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqa OCA], [~~http~~://pdbe.org/5kqa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kqa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kqa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqa ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqa OCA], [https://pdbe.org/5kqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kqa RCSB], [https://www.ebi.ac.uk/pdbsum/5kqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqa ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1W6I4R7_FAGTA A0A1W6I4R7_FAGTA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, H]]	+	[[Category: Polygonaceae]]
-	[[Category: Wang, W]]	+	[[Category: Wang H]]
-	[[Category: Wang, Z]]	+	[[Category: Wang W]]
-	[[Category: Zhang, X]]	+	[[Category: Wang Z]]
-	[[Category: Zhao, Y]]	+	[[Category: Zhang X]]
-	~~[[Category: Complex]]~~	+	[[Category: Zhao Y]]
-	~~[[Category: Glutaredoxin]]~~	+
-	~~[[Category: Glutathione]]~~	+
-	~~[[Category: Monomer]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 06:31, 5 August 2020

2020-08-05T06:31:29Z

←Older revision		Revision as of 06:31, 5 August 2020
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	==Crystal structure of buckwheat glutaredoxin-glutathione complex==		==Crystal structure of buckwheat glutaredoxin-glutathione complex==
-	<StructureSection load='5kqa' size='340' side='right' caption='[[5kqa]], [[Resolution\|resolution]] 2.05Å' scene=''>	+	<StructureSection load='5kqa' size='340' side='right'caption='[[5kqa]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KQA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KQA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqa OCA], [http://pdbe.org/5kqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kqa RCSB], [http://www.ebi.ac.uk/pdbsum/5kqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqa OCA], [http://pdbe.org/5kqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kqa RCSB], [http://www.ebi.ac.uk/pdbsum/5kqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqa ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
	[[Category: Wang, W]]		[[Category: Wang, W]]

OCA at 09:54, 27 September 2017

2017-09-27T09:54:44Z

←Older revision		Revision as of 09:54, 27 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5kqa is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of buckwheat glutaredoxin-glutathione complex==
		+	<StructureSection load='5kqa' size='340' side='right' caption='[[5kqa]], [[Resolution\|resolution]] 2.05Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kqa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KQA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kqa OCA], [http://pdbe.org/5kqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kqa RCSB], [http://www.ebi.ac.uk/pdbsum/5kqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kqa ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glutaredoxins (Grxs) are ubiquitous thioltransferases and members of the thioredoxin (Trx) fold superfamily. They have multiple functions in cells including oxidative stress responses and cell signaling. A novel glutaredoxin from buckwheat (rbGrx) with higher catalytic activity was identified, cloned, and purified. The structures of glutathionylated rbGrx and an rbGrx mutant, in which cysteine 39 was mutated to alanine, were solved by x-ray diffraction at a resolution of 2.05A and 2.29A, respectively. In rbGrx, GSH (glutathione) is bound at the conserved GSH-binding site, and its structure shows that it has the potential to function as a scaffold protein for the assembly and delivery of GSH. The crystal structure shows that GSH does not bind to the C39A rbGrx mutant, and the C39A mutant had no catalytic activity, indicating that C39 is a key residue that is involved in both the binding of rbGrx to GSH and the regulation of its catalytic activity. The model showing the binding of GSH with rbGrx provides a basis for understanding its molecular function and its potential future applications in medicinal food science.

-	~~Authors: Zhang~~, X., Wang, W., ~~Zhao~~, Y., ~~Wang~~, Z., Wang, H.	+	Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity.,Zhang X, Wang W, Li C, Zhao Y, Yuan H, Tan X, Wu L, Wang Z, Wang H J Inorg Biochem. 2017 Aug;173:21-27. doi: 10.1016/j.jinorgbio.2017.04.019. Epub, 2017 Apr 27. PMID:28478310<ref>PMID:28478310</ref>

-	~~Description: Crystal structure~~ of ~~buckwheat glutaredoxin-glutathione complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Wang, W]]~~	+	<div class="pdbe-citations 5kqa" style="background-color:#fffaf0;"></div>
-	~~[[Category: Zhao, Y]]~~	+	== References ==
-	~~[[Category: Zhang, X]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Wang, H]]		[[Category: Wang, H]]
		+	[[Category: Wang, W]]
	[[Category: Wang, Z]]		[[Category: Wang, Z]]
		+	[[Category: Zhang, X]]
		+	[[Category: Zhao, Y]]
		+	[[Category: Complex]]
		+	[[Category: Glutaredoxin]]
		+	[[Category: Glutathione]]
		+	[[Category: Monomer]]
		+	[[Category: Oxidoreductase]]

OCA at 10:22, 9 March 2017

2017-03-09T10:22:18Z

←Older revision		Revision as of 10:22, 9 March 2017
Line 7:		Line 7:
	Description: Crystal structure of buckwheat glutaredoxin-glutathione complex		Description: Crystal structure of buckwheat glutaredoxin-glutathione complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zhang, X]]
-	[[Category: Wang, Z]]
	[[Category: Wang, W]]		[[Category: Wang, W]]
	[[Category: Zhao, Y]]		[[Category: Zhao, Y]]
		+	[[Category: Zhang, X]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
		+	[[Category: Wang, Z]]

OCA: Protected "5kqa" [edit=sysop:move=sysop]

2016-07-14T09:34:49Z

Protected "5kqa" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:34, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kqa is ON HOLD until Paper Publication Authors: Zhang, X., Wang, W., Zhao, Y., Wang, Z., Wang, H. Description: Crystal structure of buckwheat glut...

2016-07-14T09:34:47Z

New page: '''Unreleased structure''' The entry 5kqa is ON HOLD until Paper Publication Authors: Zhang, X., Wang, W., Zhao, Y., Wang, Z., Wang, H. Description: Crystal structure of buckwheat glut...

New page

'''Unreleased structure'''

The entry 5kqa is ON HOLD until Paper Publication

Authors: Zhang, X., Wang, W., Zhao, Y., Wang, Z., Wang, H.

Description: Crystal structure of buckwheat glutaredoxin-glutathione complex
[[Category: Unreleased Structures]]
[[Category: Zhang, X]]
[[Category: Wang, Z]]
[[Category: Wang, W]]
[[Category: Zhao, Y]]
[[Category: Wang, H]]