5kuk - Revision history

OCA at 10:55, 27 September 2023

2023-09-27T10:55:15Z

←Older revision		Revision as of 10:55, 27 September 2023
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	<StructureSection load='5kuk' size='340' side='right'caption='[[5kuk]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5kuk' size='340' side='right'caption='[[5kuk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KUK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KUK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=DMU:DECYL~~-~~BETA-D-MALTOPYRANOSIDE'>DMU</scene>~~, ~~<scene name='pdbligand=K:POTASSIUM+ION'>K</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5kum\|5kum]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">KCNJ12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [https://pdbe.org/5kuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [https://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [~~http~~://pdbe.org/5kuk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK]] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>	+	[https://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Heyman, S]]	+	[[Category: Heyman S]]
-	[[Category: Lee, S J]]	+	[[Category: Lee S-J]]
-	[[Category: Nichols~~, C G~~]]	+	[[Category: Nichols CG]]
-	[[Category: Ren, F]]	+	[[Category: Ren F]]
-	[[Category: Yuan, P]]	+	[[Category: Yuan P]]
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Metal transport kir 2 2 k62w mutant structure~~]]	+

OCA at 09:16, 4 December 2019

2019-12-04T09:16:41Z

←Older revision		Revision as of 09:16, 4 December 2019
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	==Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant==		==Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant==
-	<StructureSection load='5kuk' size='340' side='right' caption='[[5kuk]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5kuk' size='340' side='right'caption='[[5kuk]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kum\|5kum]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kum\|5kum]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">KCNJ12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [http://pdbe.org/5kuk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [http://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [http://pdbe.org/5kuk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [http://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5kuk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5kuk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Heyman, S]]		[[Category: Heyman, S]]
	[[Category: Lee, S J]]		[[Category: Lee, S J]]

OCA at 04:52, 9 September 2016

2016-09-09T04:52:06Z

←Older revision		Revision as of 04:52, 9 September 2016
Line 10:		Line 10:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK]] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>		[[http://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK]] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP2) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but interaction of bulk anionic phospholipid (PL(-)) with a distinct second site is required for high PIP2 sensitivity. Here we show that introduction of a lipid-partitioning tryptophan at the second site (K62W) generates high PIP2 sensitivity, even in the absence of PL(-) Furthermore, high-resolution x-ray crystal structures of Kir2.2[K62W], with or without added PIP2 (2.8- and 2.0-A resolution, respectively), reveal tight tethering of the C-terminal domain (CTD) to the transmembrane domain (TMD) in each condition. Our results suggest a refined model for phospholipid gating in which PL(-) binding at the second site pulls the CTD toward the membrane, inducing the formation of the high-affinity primary PIP2 site and explaining the positive allostery between PL(-) binding and PIP2 sensitivity.
		+
		+	Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.,Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug , 15. PMID:27527100<ref>PMID:27527100</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5kuk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:29, 10 August 2016

2016-08-10T16:29:30Z

←Older revision		Revision as of 16:29, 10 August 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5kuk is ~~ON HOLD~~	+	==Crystal Structure of Inward Rectifier Kir2.2 K62W Mutant==
-		+	<StructureSection load='5kuk' size='340' side='right' caption='[[5kuk]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5kuk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUK FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kum\|5kum]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuk OCA], [http://pdbe.org/5kuk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuk RCSB], [http://www.ebi.ac.uk/pdbsum/5kuk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuk ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCJ12_CHICK KCJ12_CHICK]] Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The inward rectification is probably due to the blockage of outward current by cytoplasmic polyamines and/or magnesium ions.<ref>PMID:20019282</ref> <ref>PMID:21874019</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Heyman, S]]
		+	[[Category: Lee, S J]]
		+	[[Category: Nichols, C G]]
		+	[[Category: Ren, F]]
		+	[[Category: Yuan, P]]
		+	[[Category: Metal transport]]
		+	[[Category: Metal transport kir 2 2 k62w mutant structure]]

OCA: Protected "5kuk" [edit=sysop:move=sysop]

2016-07-26T12:57:01Z

Protected "5kuk" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:57, 26 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kuk is ON HOLD Authors: Description: Category: Unreleased Structures

2016-07-26T12:56:59Z

New page: '''Unreleased structure''' The entry 5kuk is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5kuk is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]