5kwx - Revision history

OCA at 10:14, 14 June 2023

2023-06-14T10:14:02Z

←Older revision		Revision as of 10:14, 14 June 2023
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	==NMR Solution Structure of Designed Peptide NC_EEH_D1==		==NMR Solution Structure of Designed Peptide NC_EEH_D1==
-	<StructureSection load='5kwx' size='340' side='right'caption='[[5kwx~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5kwx' size='340' side='right'caption='[[5kwx]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kwx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5KWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kwx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KWX FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kvn\|5kvn]], [[5kwo\|5kwo]], [[5kwp\|5kwp]], [[5kwz\|5kwz]], [[5kx0\|5kx0]], [[5kx1\|5kx1]], [[5kx2\|5kx2]]</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwx OCA], [https://pdbe.org/5kwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kwx RCSB], [https://www.ebi.ac.uk/pdbsum/5kwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwx ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwx OCA], [~~http~~://pdbe.org/5kwx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5kwx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5kwx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwx ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Craik, D J~~]]	+	[[Category: Synthetic construct]]
-	[[Category: ~~Harvey, P J~~]]	+	[[Category: Craik DJ]]
-	[[Category: ~~De novo protein]]~~	+	[[Category: Harvey PJ]]
-	~~[[Category: Designed peptide~~]]	+

OCA at 06:36, 5 August 2020

2020-08-05T06:36:12Z

←Older revision		Revision as of 06:36, 5 August 2020
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	==NMR Solution Structure of Designed Peptide NC_EEH_D1==		==NMR Solution Structure of Designed Peptide NC_EEH_D1==
-	<StructureSection load='5kwx' size='340' side='right' caption='[[5kwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5kwx' size='340' side='right'caption='[[5kwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5kwx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5KWX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5kwx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5KWX FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kvn\|5kvn]], [[5kwo\|5kwo]], [[5kwp\|5kwp]], [[5kwz\|5kwz]], [[5kx0\|5kx0]], [[5kx1\|5kx1]], [[5kx2\|5kx2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kvn\|5kvn]], [[5kwo\|5kwo]], [[5kwp\|5kwp]], [[5kwz\|5kwz]], [[5kx0\|5kx0]], [[5kx1\|5kx1]], [[5kx2\|5kx2]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwx OCA], [http://pdbe.org/5kwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwx RCSB], [http://www.ebi.ac.uk/pdbsum/5kwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwx OCA], [http://pdbe.org/5kwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwx RCSB], [http://www.ebi.ac.uk/pdbsum/5kwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Craik, D J]]		[[Category: Craik, D J]]
	[[Category: Harvey, P J]]		[[Category: Harvey, P J]]
	[[Category: De novo protein]]		[[Category: De novo protein]]
	[[Category: Designed peptide]]		[[Category: Designed peptide]]

OCA at 13:57, 21 September 2016

2016-09-21T13:57:40Z

←Older revision		Revision as of 13:57, 21 September 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5kwx is ~~ON HOLD until Paper~~ Publication	+	==NMR Solution Structure of Designed Peptide NC_EEH_D1==
		+	<StructureSection load='5kwx' size='340' side='right' caption='[[5kwx]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5kwx]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KWX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KWX FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kvn\|5kvn]], [[5kwo\|5kwo]], [[5kwp\|5kwp]], [[5kwz\|5kwz]], [[5kx0\|5kx0]], [[5kx1\|5kx1]], [[5kx2\|5kx2]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kwx OCA], [http://pdbe.org/5kwx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kwx RCSB], [http://www.ebi.ac.uk/pdbsum/5kwx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kwx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Naturally occurring, pharmacologically active peptides constrained with covalent crosslinks generally have shapes that have evolved to fit precisely into binding pockets on their targets. Such peptides can have excellent pharmaceutical properties, combining the stability and tissue penetration of small-molecule drugs with the specificity of much larger protein therapeutics. The ability to design constrained peptides with precisely specified tertiary structures would enable the design of shape-complementary inhibitors of arbitrary targets. Here we describe the development of computational methods for accurate de novo design of conformationally restricted peptides, and the use of these methods to design 18-47 residue, disulfide-crosslinked peptides, a subset of which are heterochiral and/or N-C backbone-cyclized. Both genetically encodable and non-canonical peptides are exceptionally stable to thermal and chemical denaturation, and 12 experimentally determined X-ray and NMR structures are nearly identical to the computational design models. The computational design methods and stable scaffolds presented here provide the basis for development of a new generation of peptide-based drugs.

-	~~Authors:~~ Harvey, ~~P.J.~~, Craik, D.J.	+	Accurate de novo design of hyperstable constrained peptides.,Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D Nature. 2016 Sep 14. doi: 10.1038/nature19791. PMID:27626386<ref>PMID:27626386</ref>

-	~~Description: NMR Solution Structure~~ of ~~Designed Peptide NC_EEH_D1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Harvey, P.J]]	+	<div class="pdbe-citations 5kwx" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Craik, D.J~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Craik, D J]]
		+	[[Category: Harvey, P J]]
		+	[[Category: De novo protein]]
		+	[[Category: Designed peptide]]

OCA at 13:50, 10 August 2016

2016-08-10T13:50:47Z

←Older revision		Revision as of 13:50, 10 August 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5kwx is ON HOLD	+	The entry 5kwx is ON HOLD until Paper Publication

	Authors: Harvey, P.J., Craik, D.J.		Authors: Harvey, P.J., Craik, D.J.

OCA: Protected "5kwx" [edit=sysop:move=sysop]

2016-07-27T13:29:10Z

Protected "5kwx" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:29, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5kwx is ON HOLD Authors: Harvey, P.J., Craik, D.J. Description: NMR Solution Structure of Designed Peptide NC_EEH_D1 [[Category: Unreleased Structu...

2016-07-27T13:29:09Z

New page: '''Unreleased structure''' The entry 5kwx is ON HOLD Authors: Harvey, P.J., Craik, D.J. Description: NMR Solution Structure of Designed Peptide NC_EEH_D1 [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 5kwx is ON HOLD

Authors: Harvey, P.J., Craik, D.J.

Description: NMR Solution Structure of Designed Peptide NC_EEH_D1
[[Category: Unreleased Structures]]
[[Category: Harvey, P.J]]
[[Category: Craik, D.J]]