5lpq - Revision history

OCA at 18:40, 18 October 2023

2023-10-18T18:40:37Z

←Older revision		Revision as of 18:40, 18 October 2023
Line 3:		Line 3:
	<StructureSection load='5lpq' size='340' side='right'caption='[[5lpq]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='5lpq' size='340' side='right'caption='[[5lpq]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lpq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LPQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lpq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_ZM4_=_ATCC_31821 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LPQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=72C:4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one'>72C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lpo\|5lpo]], [[4kwo\|4kwo]], [[4leq\|4leq]], [[4puk\|4puk]], [[5i00\|5i00]], [[5i02\|5i02]], [[5i06\|5i06]], [[5i07\|5i07]], [[1p0d\|1p0d]], [[5lpp\|5lpp]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=72C:4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one'>72C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpq OCA], [https://pdbe.org/5lpq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lpq RCSB], [https://www.ebi.ac.uk/pdbsum/5lpq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpq OCA], [~~http~~://pdbe.org/5lpq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lpq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lpq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]	+	[https://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]

	==See Also==		==See Also==
-	*[[TRNA-guanine transglycosylase\|TRNA-guanine transglycosylase]]	+	*[[TRNA-guanine transglycosylase 3D structures\|TRNA-guanine transglycosylase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Ehrmann, F R~~]]	+	[[Category: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821]]
-	[[Category: ~~Heine, A~~]]	+	[[Category: Ehrmann FR]]
-	[[Category: ~~Klebe, G~~]]	+	[[Category: Heine A]]
-	[[Category: ~~Carbohydrate-based inhibitor]]~~	+	[[Category: Klebe G]]
-	~~[[Category: Homodimer]]~~	+
-	~~[[Category: Shigellosis]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transferase inhibitor~~]]	+

OCA at 10:45, 12 August 2020

2020-08-12T10:45:41Z

←Older revision		Revision as of 10:45, 12 August 2020
Line 1:		Line 1:

	==tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one==		==tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one==
-	<StructureSection load='5lpq' size='340' side='right' caption='[[5lpq]], [[Resolution\|resolution]] 2.52Å' scene=''>	+	<StructureSection load='5lpq' size='340' side='right'caption='[[5lpq]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lpq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LPQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lpq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LPQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=72C:4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one'>72C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=72C:4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one'>72C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lpo\|5lpo]], [[4kwo\|4kwo]], [[4leq\|4leq]], [[4puk\|4puk]], [[5i00\|5i00]], [[5i02\|5i02]], [[5i06\|5i06]], [[5i07\|5i07]], [[1p0d\|1p0d]], [[5lpp\|5lpp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lpo\|5lpo]], [[4kwo\|4kwo]], [[4leq\|4leq]], [[4puk\|4puk]], [[5i00\|5i00]], [[5i02\|5i02]], [[5i06\|5i06]], [[5i07\|5i07]], [[1p0d\|1p0d]], [[5lpp\|5lpp]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpq OCA], [http://pdbe.org/5lpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpq RCSB], [http://www.ebi.ac.uk/pdbsum/5lpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpq OCA], [http://pdbe.org/5lpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpq RCSB], [http://www.ebi.ac.uk/pdbsum/5lpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]		[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
		+
		+	==See Also==
		+	*[[TRNA-guanine transglycosylase\|TRNA-guanine transglycosylase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ehrmann, F R]]		[[Category: Ehrmann, F R]]
	[[Category: Heine, A]]		[[Category: Heine, A]]

OCA at 14:57, 5 September 2017

2017-09-05T14:57:05Z

←Older revision		Revision as of 14:57, 5 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5lpq is ON HOLD until Paper Publication~~	+	==tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one==
-		+	<StructureSection load='5lpq' size='340' side='right' caption='[[5lpq]], [[Resolution\|resolution]] 2.52Å' scene=''>
-	~~Authors: Ehrmann, F.R., Heine, A., Klebe, G.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5lpq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LPQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LPQ FirstGlance]. <br>
-	~~Description:~~ tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=72C:4-[2-[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-methoxy-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]ethyl]-6-azanyl-2-(methylamino)-1,7-dihydroimidazo[4,5-g]quinazolin-8-one'>72C</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5lpo\|5lpo]], [[4kwo\|4kwo]], [[4leq\|4leq]], [[4puk\|4puk]], [[5i00\|5i00]], [[5i02\|5i02]], [[5i06\|5i06]], [[5i07\|5i07]], [[1p0d\|1p0d]], [[5lpp\|5lpp]]</td></tr>
-	[[Category: Ehrmann, F.R]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/tRNA-guanine(34)_transglycosylase tRNA-guanine(34) transglycosylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.29 2.4.2.29] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lpq OCA], [http://pdbe.org/5lpq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lpq RCSB], [http://www.ebi.ac.uk/pdbsum/5lpq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lpq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ehrmann, F R]]
	[[Category: Heine, A]]		[[Category: Heine, A]]
	[[Category: Klebe, G]]		[[Category: Klebe, G]]
		+	[[Category: Carbohydrate-based inhibitor]]
		+	[[Category: Homodimer]]
		+	[[Category: Shigellosis]]
		+	[[Category: Transferase]]
		+	[[Category: Transferase inhibitor]]

OCA at 10:48, 9 March 2017

2017-03-09T10:48:17Z

←Older revision		Revision as of 10:48, 9 March 2017
Line 7:		Line 7:
	Description: tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one		Description: tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Klebe, G]]
	[[Category: Ehrmann, F.R]]		[[Category: Ehrmann, F.R]]
	[[Category: Heine, A]]		[[Category: Heine, A]]
		+	[[Category: Klebe, G]]

OCA: Protected "5lpq" [edit=sysop:move=sysop]

2016-09-09T15:10:15Z

Protected "5lpq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:10, 9 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lpq is ON HOLD until Paper Publication Authors: Ehrmann, F.R., Heine, A., Klebe, G. Description: tRNA guanine Transglycosylase (TGT) in co-crystal...

2016-09-09T15:10:14Z

New page: '''Unreleased structure''' The entry 5lpq is ON HOLD until Paper Publication Authors: Ehrmann, F.R., Heine, A., Klebe, G. Description: tRNA guanine Transglycosylase (TGT) in co-crystal...

New page

'''Unreleased structure'''

The entry 5lpq is ON HOLD until Paper Publication

Authors: Ehrmann, F.R., Heine, A., Klebe, G.

Description: tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-4-(2-((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)ethyl)-2-(methylamino)-1H-imidazo[4,5-g]quinazolin-8(7H)-one
[[Category: Unreleased Structures]]
[[Category: Klebe, G]]
[[Category: Ehrmann, F.R]]
[[Category: Heine, A]]