5lst - Revision history

OCA at 18:46, 18 October 2023

2023-10-18T18:46:33Z

←Older revision		Revision as of 18:46, 18 October 2023
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	==Crystal structure of the human RecQL4 helicase.==		==Crystal structure of the human RecQL4 helicase.==
-	<StructureSection load='5lst' size='340' side='right' caption='[[5lst]], [[Resolution\|resolution]] 2.75Å' scene=''>	+	<StructureSection load='5lst' size='340' side='right'caption='[[5lst]], [[Resolution\|resolution]] 2.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lst]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LST OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LST FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lst]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LST FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.75Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">RECQL4, RECQ4 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lst OCA], [https://pdbe.org/5lst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lst RCSB], [https://www.ebi.ac.uk/pdbsum/5lst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lst ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lst OCA], [~~http~~://pdbe.org/5lst PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lst RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lst PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lst ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] RAPADILINO syndrome;Baller-Gerold syndrome;Rothmund-Thomson syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN] RAPADILINO syndrome;Baller-Gerold syndrome;Rothmund-Thomson syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] DNA-dependent ATPase. May modulate chromosome segregation.<ref>PMID:15317757</ref>	+	[https://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN] DNA-dependent ATPase. May modulate chromosome segregation.<ref>PMID:15317757</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5lst" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lst" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Helicase 3D structures\|Helicase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~DNA helicase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Kaiser, S]]	+	[[Category: Kaiser S]]
-	[[Category: Kisker, C]]	+	[[Category: Kisker C]]
-	[[Category: Sauer, F]]	+	[[Category: Sauer F]]
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Rapadilino-syndrome]]~~	+
-	~~[[Category: Recq4]]~~	+
-	~~[[Category: Rothmund-thomson-syndrome~~]]	+

OCA at 06:28, 16 November 2017

2017-11-16T06:28:46Z

←Older revision		Revision as of 06:28, 16 November 2017
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-	'''Unreleased structure'''

-	The entry ~~5lst~~ is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of the human RecQL4 helicase.==
		+	<StructureSection load='5lst' size='340' side='right' caption='[[5lst]], [[Resolution\|resolution]] 2.75Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lst]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LST OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LST FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">RECQL4, RECQ4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lst OCA], [http://pdbe.org/5lst PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lst RCSB], [http://www.ebi.ac.uk/pdbsum/5lst PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lst ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] RAPADILINO syndrome;Baller-Gerold syndrome;Rothmund-Thomson syndrome type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RECQ4_HUMAN RECQ4_HUMAN]] DNA-dependent ATPase. May modulate chromosome segregation.<ref>PMID:15317757</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	RecQ4 is a member of the RecQ helicase family, an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair and replication. While reduced RecQ4 activity is associated with cancer predisposition and premature aging, RecQ4 upregulation is related to carcinogenesis and metastasis. Within the RecQ family, RecQ4 assumes an exceptional position, lacking several characteristic RecQ domains. Here we present the crystal structure of human RecQ4, encompassing the conserved ATPase core and a novel C-terminal domain that lacks resemblance to the RQC domain observed in other RecQ helicases. The new domain features a zinc-binding site and two distinct types of winged-helix domains, which are not involved in canonical DNA binding or helicase activity. Based on our structural and functional analysis, we propose that RecQ4 exerts a helicase mechanism, which may be more closely related to bacterial RecQ helicases than to its human family members.

-	~~Authors~~:	+	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism.,Kaiser S, Sauer F, Kisker C Nat Commun. 2017 Jun 27;8:15907. doi: 10.1038/ncomms15907. PMID:28653661<ref>PMID:28653661</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5lst" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA helicase]]
		+	[[Category: Human]]
		+	[[Category: Kaiser, S]]
		+	[[Category: Kisker, C]]
		+	[[Category: Sauer, F]]
		+	[[Category: Helicase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Rapadilino-syndrome]]
		+	[[Category: Recq4]]
		+	[[Category: Rothmund-thomson-syndrome]]

OCA: Protected "5lst" [edit=sysop:move=sysop]

2016-09-14T13:39:04Z

Protected "5lst" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:39, 14 September 2016

OCA: New page: '''Unreleased structure''' The entry 5lst is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2016-09-14T13:39:03Z

New page: '''Unreleased structure''' The entry 5lst is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5lst is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]