5ly6 - Revision history

OCA at 10:56, 25 October 2023

2023-10-25T10:56:24Z

←Older revision		Revision as of 10:56, 25 October 2023
Line 3:		Line 3:
	<SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>		<SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strp2 Strp2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_D39 Streptococcus pneumoniae D39]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ply~~, ~~SPD_1726 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=373153 STRP2])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [~~http~~://pdbe.org/5ly6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [https://pdbe.org/5ly6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).	+	[https://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strp2~~]]	+	[[Category: Streptococcus pneumoniae D39]]
-	[[Category: Imprima, E D]]	+	[[Category: D'Imprima E]]
-	[[Category: Kuehlbrandt, W]]	+	[[Category: Kuehlbrandt W]]
-	[[Category: Mills~~, D J~~]]	+	[[Category: Mills DJ]]
-	[[Category: Neuhaus, A]]	+	[[Category: Neuhaus A]]
-	~~[[Category: Pee, K van~~]]	+	[[Category: Yildiz O]]
-	[[Category: Yildiz, O]]	+	[[Category: Van Pee K]]
-	[[Category: ~~Bacterial toxin]]~~	+
-	~~[[Category: Cholesterol-dependent cytolysin]]~~	+
-	~~[[Category: Cryoem structure]]~~	+
-	~~[[Category: Membrane pore]]~~	+
-	~~[[Category: Pneumolysin]]~~	+
-	~~[[Category: Pore complex]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 20:47, 10 April 2020

2020-04-10T20:47:30Z

←Older revision		Revision as of 20:47, 10 April 2020
Line 3:		Line 3:
	<SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>		<SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ply, SPD_1726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373153 STRP2])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ply, SPD_1726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373153 STRP2])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [http://pdbe.org/5ly6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [http://pdbe.org/5ly6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:00, 6 March 2020

2020-03-06T19:00:58Z

←Older revision		Revision as of 19:00, 6 March 2020
Line 1:		Line 1:

	==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A==		==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A==
-	<~~StructureSection~~ load='5ly6' size='340' side='right'caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<SX load='5ly6' size='340' side='right' viewer='molstar' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Strp2]]		[[Category: Strp2]]

OCA at 10:54, 2 October 2019

2019-10-02T10:54:05Z

←Older revision		Revision as of 10:54, 2 October 2019
Line 1:		Line 1:

	==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A==		==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A==
-	<StructureSection load='5ly6' size='340' side='right' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>	+	<StructureSection load='5ly6' size='340' side='right'caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5ly6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ly6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytolysin 3D structures\|Cytolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Strp2]]		[[Category: Strp2]]
	[[Category: Imprima, E D]]		[[Category: Imprima, E D]]

OCA at 03:31, 16 November 2017

2017-11-16T03:31:38Z

←Older revision		Revision as of 03:31, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5ly6' size='340' side='right' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>		<StructureSection load='5ly6' size='340' side='right' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strp2 Strp2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [http://pdbe.org/5ly6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ply, SPD_1726 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=373153 STRP2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [http://pdbe.org/5ly6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Strp2]]
	[[Category: Imprima, E D]]		[[Category: Imprima, E D]]
	[[Category: Kuehlbrandt, W]]		[[Category: Kuehlbrandt, W]]

OCA at 13:22, 5 April 2017

2017-04-05T13:22:25Z

←Older revision		Revision as of 13:22, 5 April 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ly6 is ~~ON HOLD until Paper~~ Publication	+	==CryoEM structure of the membrane pore complex of Pneumolysin at 4.5A==
		+	<StructureSection load='5ly6' size='340' side='right' caption='[[5ly6]], [[Resolution\|resolution]] 4.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ly6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LY6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LY6 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ly6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ly6 OCA], [http://pdbe.org/5ly6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ly6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ly6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ly6 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TACY_STRP2 TACY_STRP2]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Many pathogenic bacteria produce pore-forming toxins to attack and kill human cells. We have determined the 4.5 A structure of the ~2.2 MDa pore complex of pneumolysin, the main virulence factor of Streptococcus pneumoniae, by cryoEM. The pneumolysin pore is a 400 A ring of 42 membrane-inserted monomers. Domain D3 of the soluble toxin refolds into two ~85 A beta-hairpins that traverse the lipid bilayer and assemble into a 168-strand beta-barrel. The pore complex is stabilized by salt bridges between beta-hairpins of adjacent subunits and an internal alpha-barrel. The apolar outer barrel surface with large sidechains is immersed in the lipid bilayer, while the inner barrel surface is highly charged. Comparison of the cryoEM pore complex to the prepore structure obtained by electron cryo-tomography and the x-ray structure of the soluble form reveals the detailed mechanisms by which the toxin monomers insert into the lipid bilayer to perforate the target membrane.

-	~~Authors~~:	+	CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin.,van Pee K, Neuhaus A, D'Imprima E, Mills DJ, Kuhlbrandt W, Yildiz O Elife. 2017 Mar 21;6. pii: e23644. doi: 10.7554/eLife.23644. PMID:28323617<ref>PMID:28323617</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ly6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Imprima, E D]]
		+	[[Category: Kuehlbrandt, W]]
		+	[[Category: Mills, D J]]
		+	[[Category: Neuhaus, A]]
		+	[[Category: Pee, K van]]
		+	[[Category: Yildiz, O]]
		+	[[Category: Bacterial toxin]]
		+	[[Category: Cholesterol-dependent cytolysin]]
		+	[[Category: Cryoem structure]]
		+	[[Category: Membrane pore]]
		+	[[Category: Pneumolysin]]
		+	[[Category: Pore complex]]
		+	[[Category: Toxin]]

OCA at 16:10, 26 October 2016

2016-10-26T16:10:53Z

←Older revision		Revision as of 16:10, 26 October 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ly6 is ON HOLD	+	The entry 5ly6 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5ly6" [edit=sysop:move=sysop]

2016-10-05T19:20:48Z

Protected "5ly6" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:20, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5ly6 is ON HOLD Authors: Description: Category: Unreleased Structures

2016-10-05T19:20:46Z

New page: '''Unreleased structure''' The entry 5ly6 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5ly6 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]