5lzx - Revision history

OCA at 18:18, 1 November 2023

2023-11-01T18:18:48Z

←Older revision		Revision as of 18:18, 1 November 2023
Line 3:		Line 3:
	<SX load='5lzx' size='340' side='right' viewer='molstar' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>		<SX load='5lzx' size='340' side='right' viewer='molstar' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [~~http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5LZX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.67Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [~~http~~://pdbe.org/5lzx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [https://pdbe.org/5lzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [https://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]	+	[https://www.uniprot.org/uniprot/G1TM55_RABIT G1TM55_RABIT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Receptor~~ for activated protein kinase C 1\|~~Receptor~~ for activated protein kinase C 1]]	+	*[[3D sructureseceptor for activated protein kinase C 1\|3D sructureseceptor for activated protein kinase C 1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Brown, A]]	+	[[Category: Brown A]]
-	[[Category: Hegde~~, R S~~]]	+	[[Category: Hegde RS]]
-	[[Category: Murray, J]]	+	[[Category: Murray J]]
-	[[Category: Ramakrishnan, V]]	+	[[Category: Ramakrishnan V]]
-	[[Category: Shao, S]]	+	[[Category: Shao S]]
-	[[Category: Taunton, J]]	+	[[Category: Taunton J]]
-	~~[[Category: Elongation]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Translation~~]]	+

OCA at 20:50, 10 April 2020

2020-04-10T20:50:17Z

←Older revision		Revision as of 20:50, 10 April 2020
Line 3:		Line 3:
	<SX load='5lzx' size='340' side='right' viewer='molstar' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>		<SX load='5lzx' size='340' side='right' viewer='molstar' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5LZX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:01, 6 March 2020

2020-03-06T19:01:54Z

←Older revision		Revision as of 19:01, 6 March 2020
Line 1:		Line 1:

	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.==		==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.==
-	<~~StructureSection~~ load='5lzx' size='340' side='right'caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>	+	<SX load='5lzx' size='340' side='right' viewer='molstar' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: European rabbit]]		[[Category: European rabbit]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:38, 11 December 2019

2019-12-11T16:38:11Z

←Older revision		Revision as of 16:38, 11 December 2019
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.==		==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.==
-	<StructureSection load='5lzx' size='340' side='right' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>	+	<StructureSection load='5lzx' size='340' side='right'caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>		<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]		[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
Line 28:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: European rabbit]]		[[Category: European rabbit]]
		+	[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Brown, A]]		[[Category: Brown, A]]

OCA at 08:23, 10 October 2018

2018-10-10T08:23:23Z

←Older revision		Revision as of 08:23, 10 October 2018
Line 3:		Line 3:
	<StructureSection load='5lzx' size='340' side='right' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>		<StructureSection load='5lzx' size='340' side='right' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PELO, CGI-17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit]), HBS1L, HBS1, KIAA1038 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5lzx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5lzx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Receptor for activated protein kinase C 1\|Receptor for activated protein kinase C 1]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: European rabbit]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Brown, A]]		[[Category: Brown, A]]

OCA at 18:40, 10 December 2016

2016-12-10T18:40:05Z

←Older revision		Revision as of 18:40, 10 December 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.==
		+	<StructureSection load='5lzx' size='340' side='right' caption='[[5lzx]], [[Resolution\|resolution]] 3.67Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5lzx]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LZX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lzx OCA], [http://pdbe.org/5lzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lzx RCSB], [http://www.ebi.ac.uk/pdbsum/5lzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lzx ProSAT]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/PELO_HUMAN PELO_HUMAN]] Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In eukaryotes, accurate protein synthesis relies on a family of translational GTPases that pair with specific decoding factors to decipher the mRNA code on ribosomes. We present structures of the mammalian ribosome engaged with decoding factorGTPase complexes representing intermediates of translation elongation (aminoacyl-tRNAeEF1A), termination (eRF1eRF3), and ribosome rescue (PelotaHbs1l). Comparative analyses reveal that each decoding factor exploits the plasticity of the ribosomal decoding center to differentially remodel ribosomal proteins and rRNA. This leads to varying degrees of large-scale ribosome movements and implies distinct mechanisms for communicating information from the decoding center to each GTPase. Additional structural snapshots of the translation termination pathway reveal the conformational changes that choreograph the accommodation of decoding factors into the peptidyl transferase center. Our results provide a structural framework for how different states of the mammalian ribosome are selectively recognized by the appropriate decoding factorGTPase complex to ensure translational fidelity.

-	~~The entry 5lzx is ON HOLD~~	+	Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.,Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS Cell. 2016 Nov 17;167(5):1229-1240.e15. doi: 10.1016/j.cell.2016.10.046. PMID:27863242<ref>PMID:27863242</ref>

-	~~Authors: Shao~~, S.~~, Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.~~	+	<div class="pdbe-citations 5lzx" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: ~~Taunton~~, J]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Oryctolagus cuniculus]]
		+	[[Category: Brown, A]]
		+	[[Category: Hegde, R S]]
	[[Category: Murray, J]]		[[Category: Murray, J]]
-	[[Category: ~~Hegde~~, ~~R.S]]~~	+	[[Category: Ramakrishnan, V]]
-	~~[[Category: Brown, A~~]]	+
	[[Category: Shao, S]]		[[Category: Shao, S]]
-	[[Category: ~~Ramakrishnan~~, V]]	+	[[Category: Taunton, J]]
		+	[[Category: Elongation]]
		+	[[Category: Ribosome]]
		+	[[Category: Translation]]

OCA: Protected "5lzx" [edit=sysop:move=sysop]

2016-10-19T14:59:12Z

Protected "5lzx" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5lzx is ON HOLD Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S. Description: Structure of the mammalian rescue...

2016-10-19T14:59:11Z

New page: '''Unreleased structure''' The entry 5lzx is ON HOLD Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S. Description: Structure of the mammalian rescue...

New page

'''Unreleased structure'''

The entry 5lzx is ON HOLD

Authors: Shao, S., Murray, J., Brown, A., Taunton, J., Ramakrishnan, V., Hegde, R.S.

Description: Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.
[[Category: Unreleased Structures]]
[[Category: Taunton, J]]
[[Category: Murray, J]]
[[Category: Hegde, R.S]]
[[Category: Brown, A]]
[[Category: Shao, S]]
[[Category: Ramakrishnan, V]]