5m9p - Revision history

OCA at 18:33, 1 November 2023

2023-11-01T18:33:21Z

←Older revision		Revision as of 18:33, 1 November 2023
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	<StructureSection load='5m9p' size='340' side='right'caption='[[5m9p]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5m9p' size='340' side='right'caption='[[5m9p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m9p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M9P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5M9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M9P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ANG, RNASE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5m9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m9p OCA], [~~http~~://pdbe.org/5m9p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5m9p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5m9p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5m9p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m9p OCA], [https://pdbe.org/5m9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m9p RCSB], [https://www.ebi.ac.uk/pdbsum/5m9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m9p ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[~~http~~://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>	+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[https://omim.org/entry/611895 611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>	+	[https://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Acharya~~, K R~~]]	+	[[Category: Acharya KR]]
-	[[Category: Bradshaw~~, W J~~]]	+	[[Category: Bradshaw WJ]]
-	[[Category: Lee~~, R L~~]]	+	[[Category: Lee RL]]
-	[[Category: Pham~~, T T.K~~]]	+	[[Category: Pham TTK]]
-	[[Category: Rehman, S]]	+	[[Category: Rehman S]]
-	[[Category: Subramanian, V]]	+	[[Category: Subramanian V]]
-	[[Category: Thiyagarajan, N]]	+	[[Category: Thiyagarajan N]]
-	~~[[Category: Al]]~~	+
-	~~[[Category: Angiogenesis]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Rnase~~]]	+

OCA at 07:13, 19 August 2020

2020-08-19T07:13:04Z

←Older revision		Revision as of 07:13, 19 August 2020
Line 1:		Line 1:

	==Human angiogenin ALS variant T80S==		==Human angiogenin ALS variant T80S==
-	<StructureSection load='5m9p' size='340' side='right' caption='[[5m9p]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5m9p' size='340' side='right'caption='[[5m9p]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5m9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M9P OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5M9P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5m9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M9P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M9P FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5m9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m9p OCA], [http://pdbe.org/5m9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m9p RCSB], [http://www.ebi.ac.uk/pdbsum/5m9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m9p ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ANG, RNASE5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m9p OCA], [http://pdbe.org/5m9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m9p RCSB], [http://www.ebi.ac.uk/pdbsum/5m9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m9p ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5m9p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5m9p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribonuclease 3D structures\|Ribonuclease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Acharya, K R]]		[[Category: Acharya, K R]]
	[[Category: Bradshaw, W J]]		[[Category: Bradshaw, W J]]

OCA at 01:38, 11 March 2017

2017-03-11T01:38:54Z

←Older revision		Revision as of 01:38, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5m9p is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human angiogenin ALS variant T80S==
		+	<StructureSection load='5m9p' size='340' side='right' caption='[[5m9p]], [[Resolution\|resolution]] 1.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5m9p]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M9P FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m9p OCA], [http://pdbe.org/5m9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m9p RCSB], [http://www.ebi.ac.uk/pdbsum/5m9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m9p ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:[http://omim.org/entry/611895 611895]]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.<ref>PMID:17886298</ref> <ref>PMID:15557516</ref> <ref>PMID:16501576</ref> <ref>PMID:17900154</ref> <ref>PMID:18087731</ref> <ref>PMID:17703939</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ANGI_HUMAN ANGI_HUMAN]] May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.<ref>PMID:1400510</ref> <ref>PMID:19354288</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mutations in Angiogenin (ANG), a member of the Ribonuclease A superfamily (also known as RNase 5) are known to be associated with Amyotrophic Lateral Sclerosis (ALS, motor neurone disease) (sporadic and familial) and Parkinson's Disease (PD). In our previous studies we have shown that ANG is expressed in neurons during neuro-ectodermal differentiation, and that it has both neurotrophic and neuroprotective functions. In addition, in an extensive study on selective ANG-ALS variants we correlated the structural changes to the effects on neuronal survival and the ability to induce stress granules in neuronal cell lines. Furthermore, we have established that ANG-ALS variants which affect the structure of the catalytic site and either decrease or increase the RNase activity affect neuronal survival. Neuronal cell lines expressing the ANG-ALS variants also lack the ability to form stress granules. Here, we report a detailed experimental structural study on eleven new ANG-PD/ALS variants which will have implications in understanding the molecular basis underlying their role in PD and ALS.

-	~~Authors:~~ Bradshaw~~, W.J.~~, Rehman, S., Pham, ~~T.T.K., Thiygarajan,~~ N., Lee~~, R.L.~~, Subramanian, V., Acharya~~, K~~.R.	+	Structural insights into human angiogenin variants implicated in Parkinson's disease and Amyotrophic Lateral Sclerosis.,Bradshaw WJ, Rehman S, Pham TT, Thiyagarajan N, Lee RL, Subramanian V, Acharya KR Sci Rep. 2017 Feb 8;7:41996. doi: 10.1038/srep41996. PMID:28176817<ref>PMID:28176817</ref>

-	~~Description: Human angiogenin ALS variant T80S~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Lee~~, R.L]]	+	<div class="pdbe-citations 5m9p" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Acharya~~, ~~K.R~~]]	+	== References ==
-	[[Category: ~~Thiygarajan~~, N]]	+	<references/>
-	[[Category: ~~Bradshaw~~, W.J]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Acharya, K R]]
		+	[[Category: Bradshaw, W J]]
		+	[[Category: Lee, R L]]
		+	[[Category: Pham, T T.K]]
	[[Category: Rehman, S]]		[[Category: Rehman, S]]
-	[[Category: Pham, T.T.K]]
	[[Category: Subramanian, V]]		[[Category: Subramanian, V]]
		+	[[Category: Thiyagarajan, N]]
		+	[[Category: Al]]
		+	[[Category: Angiogenesis]]
		+	[[Category: Hydrolase]]
		+	[[Category: Rnase]]

OCA: Protected "5m9p" [edit=sysop:move=sysop]

2016-12-09T16:32:04Z

Protected "5m9p" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:32, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5m9p is ON HOLD until Paper Publication Authors: Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiygarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R...

2016-12-09T16:32:03Z

New page: '''Unreleased structure''' The entry 5m9p is ON HOLD until Paper Publication Authors: Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiygarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R...

New page

'''Unreleased structure'''

The entry 5m9p is ON HOLD until Paper Publication

Authors: Bradshaw, W.J., Rehman, S., Pham, T.T.K., Thiygarajan, N., Lee, R.L., Subramanian, V., Acharya, K.R.

Description: Human angiogenin ALS variant T80S
[[Category: Unreleased Structures]]
[[Category: Lee, R.L]]
[[Category: Acharya, K.R]]
[[Category: Thiygarajan, N]]
[[Category: Bradshaw, W.J]]
[[Category: Rehman, S]]
[[Category: Pham, T.T.K]]
[[Category: Subramanian, V]]