5mhf - Revision history

OCA at 18:43, 1 November 2023

2023-11-01T18:43:39Z

←Older revision		Revision as of 18:43, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='5mhf' size='340' side='right'caption='[[5mhf]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5mhf' size='340' side='right'caption='[[5mhf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mhf]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mhf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6A9:N-9-METHOXYNONYL-1-DEOXYNOJIRIMYCIN'>6A9</scene>, <scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~NAG~~:N-~~ACETYL~~-~~D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY~~:N-~~DIMETHYL~~-~~LYSINE~~'>~~MLY~~</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6A9:N-9-METHOXYNONYL-1-DEOXYNOJIRIMYCIN'>6A9</scene>, <scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mogs~~, ~~Gcs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhf OCA], [https://pdbe.org/5mhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mhf RCSB], [https://www.ebi.ac.uk/pdbsum/5mhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhf ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_glucosidase Mannosyl-oligosaccharide glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.106 3.2.1.106]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhf OCA], [~~http~~://pdbe.org/5mhf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mhf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mhf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhf ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MOGS_MOUSE MOGS_MOUSE]] Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.	+	[https://www.uniprot.org/uniprot/MOGS_MOUSE MOGS_MOUSE] Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice]]~~	+	[[Category: Mus musculus]]
-	~~[[Category: Mannosyl-oligosaccharide glucosidase~~]]	+	[[Category: Caputo AT]]
-	[[Category: Caputo~~, A T~~]]	+	[[Category: Hill JC]]
-	[[Category: Hill~~, J C~~]]	+	[[Category: Roversi P]]
-	[[Category: Roversi, P]]	+	[[Category: Zitzmann N]]
-	[[Category: Zitzmann, N]]	+
-	~~[[Category: Gh63]]~~	+
-	~~[[Category: Glucosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Iminosugar~~]]	+

OCA at 05:55, 22 April 2020

2020-04-22T05:55:37Z

←Older revision		Revision as of 05:55, 22 April 2020
Line 1:		Line 1:

	==Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin==		==Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin==
-	<StructureSection load='5mhf' size='340' side='right' caption='[[5mhf]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5mhf' size='340' side='right'caption='[[5mhf]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mhf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHF OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MHF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mhf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHF OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MHF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6A9:N-9-METHOXYNONYL-1-DEOXYNOJIRIMYCIN'>6A9</scene>, <scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6A9:N-9-METHOXYNONYL-1-DEOXYNOJIRIMYCIN'>6A9</scene>, <scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Mogs, Gcs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_glucosidase Mannosyl-oligosaccharide glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.106 3.2.1.106] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_glucosidase Mannosyl-oligosaccharide glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.106 3.2.1.106] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhf OCA], [http://pdbe.org/5mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mhf RCSB], [http://www.ebi.ac.uk/pdbsum/5mhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhf ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhf OCA], [http://pdbe.org/5mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mhf RCSB], [http://www.ebi.ac.uk/pdbsum/5mhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhf ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MOGS_MOUSE MOGS_MOUSE]] Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.		[[http://www.uniprot.org/uniprot/MOGS_MOUSE MOGS_MOUSE]] Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Influenza and dengue viruses present a growing global threat to public health. Both viruses depend on the host endoplasmic reticulum (ER) glycoprotein folding pathway. In 2014, Sadat et al. reported two siblings with a rare genetic defect in ER alpha-glucosidase I (ER Glu I) who showed resistance to viral infections, identifying ER Glu I as a key antiviral target. Here, we show that a single dose of UV-4B (the hydrochloride salt form of N-(9'-methoxynonyl)-1-deoxynojirimycin; MON-DNJ) capable of inhibiting Glu I in vivo is sufficient to prevent death in mice infected with lethal viral doses, even when treatment is started as late as 48 h post infection. The first crystal structure of mammalian ER Glu I will constitute the basis for the development of potent and selective inhibitors. Targeting ER Glu I with UV-4B-derived compounds may alter treatment paradigms for acute viral disease through development of a single-dose therapeutic regime.
		+
		+	Targeting Endoplasmic Reticulum alpha-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.,Warfield KL, Alonzi DS, Hill JC, Caputo AT, Roversi P, Kiappes JL, Sheets N, Duchars M, Dwek RA, Biggins J, Barnard D, Shresta S, Treston AM, Zitzmann N J Med Chem. 2020 Apr 15. doi: 10.1021/acs.jmedchem.0c00067. PMID:32227946<ref>PMID:32227946</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mhf" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Mannosyl-oligosaccharide glucosidase]]		[[Category: Mannosyl-oligosaccharide glucosidase]]
	[[Category: Caputo, A T]]		[[Category: Caputo, A T]]

OCA at 06:07, 20 December 2017

2017-12-20T06:07:41Z

←Older revision		Revision as of 06:07, 20 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mhf is ~~ON HOLD until Paper Publication~~	+	==Murine endoplasmic reticulum alpha-glucosidase I with N-9'-methoxynonyl-1-deoxynojirimycin==
-		+	<StructureSection load='5mhf' size='340' side='right' caption='[[5mhf]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mhf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MHF FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6A9:N-9-METHOXYNONYL-1-DEOXYNOJIRIMYCIN'>6A9</scene>, <scene name='pdbligand=7PG:2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL'>7PG</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-oligosaccharide_glucosidase Mannosyl-oligosaccharide glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.106 3.2.1.106] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhf OCA], [http://pdbe.org/5mhf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mhf RCSB], [http://www.ebi.ac.uk/pdbsum/5mhf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhf ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MOGS_MOUSE MOGS_MOUSE]] Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mannosyl-oligosaccharide glucosidase]]
		+	[[Category: Caputo, A T]]
		+	[[Category: Hill, J C]]
		+	[[Category: Roversi, P]]
		+	[[Category: Zitzmann, N]]
		+	[[Category: Gh63]]
		+	[[Category: Glucosidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Iminosugar]]

OCA: Protected "5mhf" [edit=sysop:move=sysop]

2016-12-09T16:52:13Z

Protected "5mhf" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:52, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5mhf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2016-12-09T16:52:12Z

New page: '''Unreleased structure''' The entry 5mhf is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mhf is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]