5mij - Revision history

OCA at 18:44, 1 November 2023

2023-11-01T18:44:51Z

←Older revision		Revision as of 18:44, 1 November 2023
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	<StructureSection load='5mij' size='340' side='right'caption='[[5mij]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='5mij' size='340' side='right'caption='[[5mij]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mij]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mij]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MIJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mij OCA], [~~http~~://pdbe.org/5mij PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mij RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mij PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mij ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mij OCA], [https://pdbe.org/5mij PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mij RCSB], [https://www.ebi.ac.uk/pdbsum/5mij PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mij ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ferraro, G]]	+	[[Category: Ferraro G]]
-	[[Category: Helliwell~~, J R~~]]	+	[[Category: Helliwell JR]]
-	[[Category: Merlino, A]]	+	[[Category: Merlino A]]
-	[[Category: Pontillo, N]]	+	[[Category: Pontillo N]]
-	~~[[Category: Metal transport~~]]	+

OCA at 07:20, 19 August 2020

2020-08-19T07:20:06Z

←Older revision		Revision as of 07:20, 19 August 2020
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	==X-ray structure of carboplatin-encapsulated horse spleen apoferritin==		==X-ray structure of carboplatin-encapsulated horse spleen apoferritin==
-	<StructureSection load='5mij' size='340' side='right' caption='[[5mij]], [[Resolution\|resolution]] 1.49Å' scene=''>	+	<StructureSection load='5mij' size='340' side='right'caption='[[5mij]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIJ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MIJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MIJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mij OCA], [http://pdbe.org/5mij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mij RCSB], [http://www.ebi.ac.uk/pdbsum/5mij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mij ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mij OCA], [http://pdbe.org/5mij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mij RCSB], [http://www.ebi.ac.uk/pdbsum/5mij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mij ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5mij" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5mij" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
		+	[[Category: Large Structures]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
	[[Category: Helliwell, J R]]		[[Category: Helliwell, J R]]

OCA at 06:18, 4 May 2017

2017-05-04T06:18:58Z

←Older revision		Revision as of 06:18, 4 May 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).		[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The second-generation Pt anticancer agent carboplatin (CBDCA) was encapsulated within the apo horse spleen ferritin (AFt) nanocage, and the X-ray structure of the drug-loaded protein was refined at 1.49 A resolution. Two Pt binding sites, different from the one observed in the cisplatin-encapsulated AFt, were identified in Ft subunits by inspection of anomalous electron density maps at two wavelengths and difference Fourier electron density maps, which provide the necessary sensitivity to discriminate between Pt from CBDCA and Cd ions that are present in the crystallization conditions. Pt centers coordinate to the NE2 atom of His49 and to the NE2 atom of His132, both on the inner surface of the Ft nanocage.
		+
		+	X-ray Structure of the Carboplatin-Loaded Apo-Ferritin Nanocage.,Pontillo N, Ferraro G, Helliwell JR, Amoresano A, Merlino A ACS Med Chem Lett. 2017 Feb 28;8(4):433-437. doi: 10.1021/acsmedchemlett.7b00025., eCollection 2017 Apr 13. PMID:28435532<ref>PMID:28435532</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mij" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:21, 15 March 2017

2017-03-15T21:21:11Z

←Older revision		Revision as of 21:21, 15 March 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5mij is ~~ON HOLD until Paper Publication~~	+	==X-ray structure of carboplatin-encapsulated horse spleen apoferritin==
-		+	<StructureSection load='5mij' size='340' side='right' caption='[[5mij]], [[Resolution\|resolution]] 1.49Å' scene=''>
-	~~Authors~~: ~~Pontillo~~, N., ~~Ferraro, G~~., ~~Helliwell~~, J.R., ~~Merlino, A~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mij]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MIJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MIJ FirstGlance]. <br>
-	~~Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mij FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mij OCA], [http://pdbe.org/5mij PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mij RCSB], [http://www.ebi.ac.uk/pdbsum/5mij PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mij ProSAT]</span></td></tr>
-	[[Category: ~~Helliwell, J.R~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Equus caballus]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
		+	[[Category: Helliwell, J R]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
	[[Category: Pontillo, N]]		[[Category: Pontillo, N]]
		+	[[Category: Metal transport]]

OCA at 11:20, 9 March 2017

2017-03-09T11:20:36Z

←Older revision		Revision as of 11:20, 9 March 2017
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	Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin		Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Helliwell, J.R]]
	[[Category: Ferraro, G]]		[[Category: Ferraro, G]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
	[[Category: Pontillo, N]]		[[Category: Pontillo, N]]
-	[[Category: Helliwell, J.R]]

OCA at 13:36, 2 January 2017

2017-01-02T13:36:08Z

←Older revision		Revision as of 13:36, 2 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5mij is ON HOLD	+	The entry 5mij is ON HOLD until Paper Publication

	Authors: Pontillo, N., Ferraro, G., Helliwell, J.R., Merlino, A.		Authors: Pontillo, N., Ferraro, G., Helliwell, J.R., Merlino, A.

OCA at 19:02, 22 December 2016

2016-12-22T19:02:21Z

←Older revision		Revision as of 19:02, 22 December 2016
Line 3:		Line 3:
	The entry 5mij is ON HOLD		The entry 5mij is ON HOLD

-	Authors: Pontillo, N, Ferraro, G, Helliwell, JR, Merlino, A	+	Authors: Pontillo, N., Ferraro, G., Helliwell, J.R., Merlino, A.

	Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin		Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Pontillo, N,~~ Ferraro, G, Helliwell, ~~Jr, Merlino, A~~]]	+	[[Category: Ferraro, G]]
		+	[[Category: Merlino, A]]
		+	[[Category: Pontillo, N]]
		+	[[Category: Helliwell, J.R]]

OCA: Protected "5mij" [edit=sysop:move=sysop]

2016-12-09T16:54:50Z

Protected "5mij" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:54, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5mij is ON HOLD Authors: Pontillo, N, Ferraro, G, Helliwell, JR, Merlino, A Description: X-ray structure of carboplatin-encapsulated horse spleen a...

2016-12-09T16:54:49Z

New page: '''Unreleased structure''' The entry 5mij is ON HOLD Authors: Pontillo, N, Ferraro, G, Helliwell, JR, Merlino, A Description: X-ray structure of carboplatin-encapsulated horse spleen a...

New page

'''Unreleased structure'''

The entry 5mij is ON HOLD

Authors: Pontillo, N, Ferraro, G, Helliwell, JR, Merlino, A

Description: X-ray structure of carboplatin-encapsulated horse spleen apoferritin
[[Category: Unreleased Structures]]
[[Category: Pontillo, N, Ferraro, G, Helliwell, Jr, Merlino, A]]