5mou - Revision history

OCA at 10:18, 14 June 2023

2023-06-14T10:18:18Z

←Older revision		Revision as of 10:18, 14 June 2023
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	==NMR spatial structure of scorpion alpha-like toxin BeM9==		==NMR spatial structure of scorpion alpha-like toxin BeM9==
-	<StructureSection load='5mou' size='340' side='right'caption='[[5mou~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>	+	<StructureSection load='5mou' size='340' side='right'caption='[[5mou]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buthus_eupeus Buthus~~ eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [~~http~~://pdbe.org/5mou PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mou PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [https://pdbe.org/5mou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [https://www.ebi.ac.uk/pdbsum/5mou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.	+	[https://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buthus eupeus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Arseniev, A S~~]]	+	[[Category: Mesobuthus eupeus]]
-	[[Category: ~~Berkut, A A~~]]	+	[[Category: Arseniev AS]]
-	[[Category: ~~Grishin, E V~~]]	+	[[Category: Berkut AA]]
-	[[Category: ~~Kuldushev, N A~~]]	+	[[Category: Grishin EV]]
-	[[Category: ~~Mineev, K S~~]]	+	[[Category: Kuldushev NA]]
-	[[Category: ~~Vassilevski, A A~~]]	+	[[Category: Mineev KS]]
-	[[Category: ~~Protein]]~~	+	[[Category: Vassilevski AA]]
-	~~[[Category: Protein neurotoxin~~]]	+

OCA at 13:10, 10 May 2019

2019-05-10T13:10:55Z

←Older revision		Revision as of 13:10, 10 May 2019
Line 1:		Line 1:

	==NMR spatial structure of scorpion alpha-like toxin BeM9==		==NMR spatial structure of scorpion alpha-like toxin BeM9==
-	<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>	+	<StructureSection load='5mou' size='340' side='right'caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Buthus eupeus]]		[[Category: Buthus eupeus]]
		+	[[Category: Large Structures]]
	[[Category: Arseniev, A S]]		[[Category: Arseniev, A S]]
	[[Category: Berkut, A A]]		[[Category: Berkut, A A]]

OCA at 07:22, 21 February 2019

2019-02-21T07:22:28Z

←Older revision		Revision as of 07:22, 21 February 2019
Line 1:		Line 1:

-	==NMR spatial structure of alpha-~~mammal~~ toxin BeM9==	+	==NMR spatial structure of scorpion alpha-like toxin BeM9==
	<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 07:47, 29 August 2018

2018-08-29T07:47:01Z

←Older revision		Revision as of 07:47, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [http://pdbe.org/5mou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [http://www.ebi.ac.uk/pdbsum/5mou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [http://pdbe.org/5mou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [http://www.ebi.ac.uk/pdbsum/5mou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.		[[http://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Sodium channel alpha-toxins from scorpion venom (alpha-NaTx) inhibit the inactivation of voltage-gated sodium channels. We used solution NMR to investigate the structure of BeM9 toxin from Mesobuthus eupeus scorpion, a prototype alpha-NaTx classified as an "alpha-like" toxin due to its wide spectrum of activity on insect and mammalian channels. We identified a new motif that we named "arginine hand", whereby arginine side chain forms several hydrogen bonds with main chain atoms. The arginine hand was found in the "specificity module", a part of the molecule that dictates toxin selectivity; and just single arginine-to-lysine point mutation drastically changed BeM9 selectivity profile. This article is protected by copyright. All rights reserved.
		+
		+	Refined structure of BeM9 reveals arginine hand, an overlooked structural motif in scorpion toxins affecting sodium channels.,Kuldyushev NA, Mineev KS, Berkut AA, Peigneur S, Arseniev AS, Tytgat J, Grishin EV, Vassilevski AA Proteins. 2018 Jul 14. doi: 10.1002/prot.25583. PMID:30007037<ref>PMID:30007037</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mou" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buthus eupeus]]
	[[Category: Arseniev, A S]]		[[Category: Arseniev, A S]]
	[[Category: Berkut, A A]]		[[Category: Berkut, A A]]

OCA at 06:46, 17 January 2018

2018-01-17T06:46:39Z

←Older revision		Revision as of 06:46, 17 January 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mou ~~is ON HOLD~~	+	==NMR spatial structure of alpha-mammal toxin BeM9==
-		+	<StructureSection load='5mou' size='340' side='right' caption='[[5mou]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
-	~~Authors~~: ~~Mineev, K~~.S.~~, Kuldushev, N~~.A., ~~Berkut, A~~.A., ~~Grishin~~, E.V., ~~Vassilevski, A~~.A., ~~Arseniev, A~~.S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mou]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MOU FirstGlance]. <br>
-	~~Description: NMR spatial structure of alpha-mammal toxin BeM9~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mou OCA], [http://pdbe.org/5mou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mou RCSB], [http://www.ebi.ac.uk/pdbsum/5mou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mou ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Mineev~~, K.S]]	+	== Function ==
-	[[Category: Berkut, A.A]]	+	[[http://www.uniprot.org/uniprot/SCX9_MESEU SCX9_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Has paralytic activity in mice.
-	[[Category: ~~Vassilevski~~, ~~A.A~~]]	+	__TOC__
-	[[Category: ~~Arseniev~~, A.S]]	+	</StructureSection>
-	[[Category: ~~Grishin~~, ~~E.V~~]]	+	[[Category: Arseniev, A S]]
-	[[Category: ~~Kuldushev~~, N.A]]	+	[[Category: Berkut, A A]]
		+	[[Category: Grishin, E V]]
		+	[[Category: Kuldushev, N A]]
		+	[[Category: Mineev, K S]]
		+	[[Category: Vassilevski, A A]]
		+	[[Category: Protein]]
		+	[[Category: Protein neurotoxin]]

OCA at 11:30, 9 March 2017

2017-03-09T11:30:42Z

←Older revision		Revision as of 11:30, 9 March 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Mineev, K.S]]		[[Category: Mineev, K.S]]
-	[[Category: Kuldushev, N.A]]
	[[Category: Berkut, A.A]]		[[Category: Berkut, A.A]]
	[[Category: Vassilevski, A.A]]		[[Category: Vassilevski, A.A]]
	[[Category: Arseniev, A.S]]		[[Category: Arseniev, A.S]]
	[[Category: Grishin, E.V]]		[[Category: Grishin, E.V]]
		+	[[Category: Kuldushev, N.A]]

OCA: Protected "5mou" [edit=sysop:move=sysop]

2016-12-22T19:16:02Z

Protected "5mou" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:16, 22 December 2016

OCA: New page: '''Unreleased structure''' The entry 5mou is ON HOLD Authors: Mineev, K.S., Kuldushev, N.A., Berkut, A.A., Grishin, E.V., Vassilevski, A.A., Arseniev, A.S. Description: NMR spatial str...

2016-12-22T19:16:01Z

New page: '''Unreleased structure''' The entry 5mou is ON HOLD Authors: Mineev, K.S., Kuldushev, N.A., Berkut, A.A., Grishin, E.V., Vassilevski, A.A., Arseniev, A.S. Description: NMR spatial str...

New page

'''Unreleased structure'''

The entry 5mou is ON HOLD

Authors: Mineev, K.S., Kuldushev, N.A., Berkut, A.A., Grishin, E.V., Vassilevski, A.A., Arseniev, A.S.

Description: NMR spatial structure of alpha-mammal toxin BeM9
[[Category: Unreleased Structures]]
[[Category: Mineev, K.S]]
[[Category: Kuldushev, N.A]]
[[Category: Berkut, A.A]]
[[Category: Vassilevski, A.A]]
[[Category: Arseniev, A.S]]
[[Category: Grishin, E.V]]