5mzc - Revision history

OCA at 17:54, 8 November 2023

2023-11-08T17:54:49Z

←Older revision		Revision as of 17:54, 8 November 2023
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	<StructureSection load='5mzc' size='340' side='right'caption='[[5mzc]], [[Resolution\|resolution]] 1.82Å' scene=''>		<StructureSection load='5mzc' size='340' side='right'caption='[[5mzc]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzc]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus~~ fluorescens ~~liquefaciens" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MZC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EQ:3-(5-CHLORANYL-6-ETHOXY-2-OXIDANYLIDENE-1,3-BENZOXAZOL-3-YL)PROPANOIC+ACID'>8EQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.82Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kmo, qbsG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EQ:3-(5-CHLORANYL-6-ETHOXY-2-OXIDANYLIDENE-1,3-BENZOXAZOL-3-YL)PROPANOIC+ACID'>8EQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzc OCA], [https://pdbe.org/5mzc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mzc RCSB], [https://www.ebi.ac.uk/pdbsum/5mzc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzc OCA], [~~http~~://pdbe.org/5mzc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mzc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mzc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.	+	[https://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
-	[[Category: Kynurenine 3-monooxygenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Rowland, P~~]]	+	[[Category: Pseudomonas fluorescens]]
-	[[Category: ~~Kmo]]~~	+	[[Category: Rowland P]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:33, 19 August 2020

2020-08-19T07:33:05Z

←Older revision		Revision as of 07:33, 19 August 2020
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	==Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid==		==Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid==
-	<StructureSection load='5mzc' size='340' side='right' caption='[[5mzc]], [[Resolution\|resolution]] 1.82Å' scene=''>	+	<StructureSection load='5mzc' size='340' side='right'caption='[[5mzc]], [[Resolution\|resolution]] 1.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca.weizmann.ac~~.~~il/oca-docs~~/fgij/fg.htm?mol=5MZC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MZC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EQ:3-(5-CHLORANYL-6-ETHOXY-2-OXIDANYLIDENE-1,3-BENZOXAZOL-3-YL)PROPANOIC+ACID'>8EQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8EQ:3-(5-CHLORANYL-6-ETHOXY-2-OXIDANYLIDENE-1,3-BENZOXAZOL-3-YL)PROPANOIC+ACID'>8EQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kmo, qbsG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 "Bacillus fluorescens liquefaciens" Flugge 1886])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzc OCA], [http://pdbe.org/5mzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzc RCSB], [http://www.ebi.ac.uk/pdbsum/5mzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzc OCA], [http://pdbe.org/5mzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzc RCSB], [http://www.ebi.ac.uk/pdbsum/5mzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5mzc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5mzc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Kynurenine 3-monooxygenase]]		[[Category: Kynurenine 3-monooxygenase]]
		+	[[Category: Large Structures]]
	[[Category: Rowland, P]]		[[Category: Rowland, P]]
	[[Category: Kmo]]		[[Category: Kmo]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 13:01, 19 April 2017

2017-04-19T13:01:27Z

←Older revision		Revision as of 13:01, 19 April 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5mzc is ~~ON HOLD~~	+	==Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-ethoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid==
		+	<StructureSection load='5mzc' size='340' side='right' caption='[[5mzc]], [[Resolution\|resolution]] 1.82Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mzc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZC FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8EQ:3-(5-CHLORANYL-6-ETHOXY-2-OXIDANYLIDENE-1,3-BENZOXAZOL-3-YL)PROPANOIC+ACID'>8EQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzc OCA], [http://pdbe.org/5mzc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzc RCSB], [http://www.ebi.ac.uk/pdbsum/5mzc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzc ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recently, we reported a novel role for KMO in the pathogenesis of acute pancreatitis (AP). A number of inhibitors of kynurenine 3-monooxygenase (KMO) have previously been described as potential treatments for neurodegenerative conditions and particularly for Huntington's disease. However, the inhibitors reported to date have insufficient aqueous solubility relative to their cellular potency to be compatible with the intravenous (iv) dosing route required in AP. We have identified and optimized a novel series of high affinity KMO inhibitors with favorable physicochemical properties. The leading example is exquisitely selective, has low clearance in two species, prevents lung and kidney damage in a rat model of acute pancreatitis, and is progressing into preclinical development.

-	~~Authors~~:	+	Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.,Walker AL, Ancellin N, Beaufils B, Bergeal M, Binnie M, Bouillot A, Clapham D, Denis A, Haslam CP, Holmes DS, Hutchinson JP, Liddle J, McBride A, Mirguet O, Mowat CG, Rowland P, Tiberghien N, Trottet L, Uings I, Webster SP, Zheng X, Mole DJ J Med Chem. 2017 Apr 11. doi: 10.1021/acs.jmedchem.7b00055. PMID:28398044<ref>PMID:28398044</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mzc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Kynurenine 3-monooxygenase]]
		+	[[Category: Rowland, P]]
		+	[[Category: Kmo]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "5mzc" [edit=sysop:move=sysop]

2017-03-09T11:49:40Z

Protected "5mzc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:49, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5mzc is ON HOLD Authors: Description: Category: Unreleased Structures

2017-03-09T11:49:39Z

New page: '''Unreleased structure''' The entry 5mzc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mzc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]