5mzs - Revision history

OCA at 17:55, 8 November 2023

2023-11-08T17:55:08Z

←Older revision		Revision as of 17:55, 8 November 2023
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	<StructureSection load='5mzs' size='340' side='right'caption='[[5mzs]], [[Resolution\|resolution]] 2.67Å' scene=''>		<StructureSection load='5mzs' size='340' side='right'caption='[[5mzs]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzs]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pseae Pseae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MZS FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~pfeA~~, ~~PA2688 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=208964 PSEAE])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.67Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzs OCA], [~~http~~://pdbe.org/5mzs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mzs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mzs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzs ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzs OCA], [https://pdbe.org/5mzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mzs RCSB], [https://www.ebi.ac.uk/pdbsum/5mzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PFEA_PSEAE PFEA_PSEAE]] Specific receptor for the siderophore ferric enterobactin.	+	[https://www.uniprot.org/uniprot/PFEA_PSEAE PFEA_PSEAE] Specific receptor for the siderophore ferric enterobactin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pseae~~]]	+	[[Category: Pseudomonas aeruginosa PAO1]]
-	[[Category: Moynie, L]]	+	[[Category: Moynie L]]
-	[[Category: Naismith~~, J H]]~~	+	[[Category: Naismith JH]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Outer membrane receptor]]~~	+
-	~~[[Category: Pa2688]]~~	+
-	~~[[Category: Pfea~~]]	+

OCA at 15:48, 28 August 2019

2019-08-28T15:48:02Z

←Older revision		Revision as of 15:48, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of the ferric enterobactin receptor (PfeA) mutant (R480A_Q482A) from Pseudomonas aeruginosa==		==Crystal structure of the ferric enterobactin receptor (PfeA) mutant (R480A_Q482A) from Pseudomonas aeruginosa==
-	<StructureSection load='5mzs' size='340' side='right' caption='[[5mzs]], [[Resolution\|resolution]] 2.67Å' scene=''>	+	<StructureSection load='5mzs' size='340' side='right'caption='[[5mzs]], [[Resolution\|resolution]] 2.67Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZS FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzs OCA], [http://pdbe.org/5mzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzs RCSB], [http://www.ebi.ac.uk/pdbsum/5mzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzs ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pfeA, PA2688 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzs OCA], [http://pdbe.org/5mzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzs RCSB], [http://www.ebi.ac.uk/pdbsum/5mzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzs ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/PFEA_PSEAE PFEA_PSEAE]] Specific receptor for the siderophore ferric enterobactin.		[[http://www.uniprot.org/uniprot/PFEA_PSEAE PFEA_PSEAE]] Specific receptor for the siderophore ferric enterobactin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacteria use small molecules called siderophores to scavenge iron. Siderophore-Fe(3+) complexes are recognised by outer-membrane transporters and imported into the periplasm in a process dependent on the inner-membrane protein TonB. The siderophore enterobactin is secreted by members of the family Enterobacteriaceae, but many other bacteria including Pseudomonas species can use it. Here, we show that the Pseudomonas transporter PfeA recognises enterobactin using extracellular loops distant from the pore. The relevance of this site is supported by in vivo and in vitro analyses. We suggest there is a second binding site deeper inside the structure and propose that correlated changes in hydrogen bonds link binding-induced structural re-arrangements to the structural adjustment of the periplasmic TonB-binding motif.
		+
		+	The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model.,Moynie L, Milenkovic S, Mislin GLA, Gasser V, Malloci G, Baco E, McCaughan RP, Page MGP, Schalk IJ, Ceccarelli M, Naismith JH Nat Commun. 2019 Aug 14;10(1):3673. doi: 10.1038/s41467-019-11508-y. PMID:31413254<ref>PMID:31413254</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5mzs" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferric enterobactin receptor\|Ferric enterobactin receptor]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Pseae]]
	[[Category: Moynie, L]]		[[Category: Moynie, L]]
	[[Category: Naismith, J H]]		[[Category: Naismith, J H]]

OCA at 06:22, 15 February 2018

2018-02-15T06:22:47Z

←Older revision		Revision as of 06:22, 15 February 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5mzs is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the ferric enterobactin receptor (PfeA) mutant (R480A_Q482A) from Pseudomonas aeruginosa==
-		+	<StructureSection load='5mzs' size='340' side='right' caption='[[5mzs]], [[Resolution\|resolution]] 2.67Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5mzs]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZS FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzs OCA], [http://pdbe.org/5mzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzs RCSB], [http://www.ebi.ac.uk/pdbsum/5mzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzs ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PFEA_PSEAE PFEA_PSEAE]] Specific receptor for the siderophore ferric enterobactin.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Moynie, L]]
		+	[[Category: Naismith, J H]]
		+	[[Category: Membrane protein]]
		+	[[Category: Outer membrane receptor]]
		+	[[Category: Pa2688]]
		+	[[Category: Pfea]]

OCA at 10:05, 27 April 2017

2017-04-27T10:05:53Z

←Older revision		Revision as of 10:05, 27 April 2017
Line 3:		Line 3:
	The entry 5mzs is ON HOLD until Paper Publication		The entry 5mzs is ON HOLD until Paper Publication

-	Authors: ~~Moynie, L., Naismith, J.H.~~	+	Authors:

-	Description: ~~Crystal structure of the ferric enterobactin receptor (PfeA) mutant (R480A_Q482A) from Pseudomonas aeruginosa~~	+	Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Naismith, J.H]]
-	[[Category: Moynie, L]]

OCA: Protected "5mzs" [edit=sysop:move=sysop]

2017-03-09T11:50:36Z

Protected "5mzs" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:50, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5mzs is ON HOLD until Paper Publication Authors: Moynie, L., Naismith, J.H. Description: Crystal structure of the ferric enterobactin receptor (Pfe...

2017-03-09T11:50:35Z

New page: '''Unreleased structure''' The entry 5mzs is ON HOLD until Paper Publication Authors: Moynie, L., Naismith, J.H. Description: Crystal structure of the ferric enterobactin receptor (Pfe...

New page

'''Unreleased structure'''

The entry 5mzs is ON HOLD until Paper Publication

Authors: Moynie, L., Naismith, J.H.

Description: Crystal structure of the ferric enterobactin receptor (PfeA) mutant (R480A_Q482A) from Pseudomonas aeruginosa
[[Category: Unreleased Structures]]
[[Category: Naismith, J.H]]
[[Category: Moynie, L]]