5mzx - Revision history

OCA at 17:55, 8 November 2023

2023-11-08T17:55:15Z

←Older revision		Revision as of 17:55, 8 November 2023
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	<StructureSection load='5mzx' size='340' side='right'caption='[[5mzx]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5mzx' size='340' side='right'caption='[[5mzx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5MZX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myxococcus_xanthus_DK_1622 Myxococcus xanthus DK 1622]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PS:4-DIPHOSPHO+PANTETHEINE'>4PS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5mzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzx OCA], [~~http~~://pdbe.org/5mzx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5mzx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5mzx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzx ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PS:4-DIPHOSPHO+PANTETHEINE'>4PS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzx OCA], [https://pdbe.org/5mzx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mzx RCSB], [https://www.ebi.ac.uk/pdbsum/5mzx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q1D4I4_MYXXD Q1D4I4_MYXXD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Blankenfeldt, W]]	+	[[Category: Myxococcus xanthus DK 1622]]
-	[[Category: Bock, T]]	+	[[Category: Blankenfeldt W]]
-	[[Category: Feiler, C]]	+	[[Category: Bock T]]
-	[[Category: Hoffmann, J]]	+	[[Category: Feiler C]]
-	[[Category: Luxenburger, E]]	+	[[Category: Hoffmann J]]
-	[[Category: Mueller, R]]	+	[[Category: Luxenburger E]]
-	[[Category: Schuetza, V]]	+	[[Category: Mueller R]]
-	~~[[Category: Coa transferase like fold]]~~	+	[[Category: Schuetza V]]
-	~~[[Category: Coenzyme some]]~~	+
-	~~[[Category: Decarboxylase]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 07:33, 19 August 2020

2020-08-19T07:33:21Z

←Older revision		Revision as of 07:33, 19 August 2020
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	==Crystal structure of the decarboxylase AibA/AibB in complex with 4'-diphospho pantetheine==		==Crystal structure of the decarboxylase AibA/AibB in complex with 4'-diphospho pantetheine==
-	<StructureSection load='5mzx' size='340' side='right' caption='[[5mzx]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5mzx' size='340' side='right'caption='[[5mzx]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5mzx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZX OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5MZX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5mzx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MZX FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PS:4-DIPHOSPHO+PANTETHEINE'>4PS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4PS:4-DIPHOSPHO+PANTETHEINE'>4PS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5mzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzx OCA], [http://pdbe.org/5mzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzx RCSB], [http://www.ebi.ac.uk/pdbsum/5mzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzx ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzx OCA], [http://pdbe.org/5mzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzx RCSB], [http://www.ebi.ac.uk/pdbsum/5mzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzx ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Blankenfeldt, W]]		[[Category: Blankenfeldt, W]]
	[[Category: Bock, T]]		[[Category: Bock, T]]

OCA at 09:10, 9 August 2017

2017-08-09T09:10:04Z

←Older revision		Revision as of 09:10, 9 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5mzx is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the decarboxylase AibA/AibB in complex with 4'-diphospho pantetheine==
		+	<StructureSection load='5mzx' size='340' side='right' caption='[[5mzx]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5mzx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MZX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MZX FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4PS:4-DIPHOSPHO+PANTETHEINE'>4PS</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mzx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mzx OCA], [http://pdbe.org/5mzx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mzx RCSB], [http://www.ebi.ac.uk/pdbsum/5mzx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mzx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isovaleryl coenzyme A (IV-CoA) is an important precursor for iso-fatty acids and lipids. It acts in the development of myxobacteria, which can produce this compound from acetyl-CoA through alternative IV-CoA biosynthesis (aib). A central reaction of aib is catalyzed by AibA/AibB, which acts as a cofactor-free decarboxylase despite belonging to the family of CoA-transferases. We developed an efficient expression system for AibA/AibB that allowed the determination of high-resolution crystal structures in complex with different ligands. Through mutational studies, we show that an active-site cysteine previously proposed to be involved in decarboxylation is not required for activity. Instead, AibA/AibB seems to induce an intramolecular decarboxylation by binding its substrate in a hydrophobic cavity and forcing it into a bent conformation. Our study opens opportunities for synthetic biology studies, since AibA/AibB may be suitable for the production of isobutene, a precursor of biofuels and chemicals.

-	~~Authors~~:	+	AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus.,Bock T, Luxenburger E, Hoffmann J, Schutza V, Feiler C, Muller R, Blankenfeldt W Angew Chem Int Ed Engl. 2017 Aug 7;56(33):9986-9989. doi: 10.1002/anie.201701992., Epub 2017 May 16. PMID:28508504<ref>PMID:28508504</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5mzx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Blankenfeldt, W]]
		+	[[Category: Bock, T]]
		+	[[Category: Feiler, C]]
		+	[[Category: Hoffmann, J]]
		+	[[Category: Luxenburger, E]]
		+	[[Category: Mueller, R]]
		+	[[Category: Schuetza, V]]
		+	[[Category: Coa transferase like fold]]
		+	[[Category: Coenzyme some]]
		+	[[Category: Decarboxylase]]
		+	[[Category: Lyase]]

OCA: Protected "5mzx" [edit=sysop:move=sysop]

2017-03-09T11:51:03Z

Protected "5mzx" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5mzx is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-03-09T11:51:02Z

New page: '''Unreleased structure''' The entry 5mzx is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5mzx is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]