5n74 - Revision history

OCA at 12:31, 15 November 2023

2023-11-15T12:31:04Z

←Older revision		Revision as of 12:31, 15 November 2023
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	<StructureSection load='5n74' size='340' side='right'caption='[[5n74]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='5n74' size='340' side='right'caption='[[5n74]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n74]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Galago_garnetti Galago garnetti~~] and [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N74 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5N74 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n74]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N74 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~30611 Galago garnetti])~~, ~~KAR9, YPL269W (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5n74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n74 OCA], [~~http~~://pdbe.org/5n74 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5n74 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5n74 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5n74 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n74 OCA], [https://pdbe.org/5n74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n74 RCSB], [https://www.ebi.ac.uk/pdbsum/5n74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n74 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~MARE1_HUMAN MARE1_HUMAN~~]] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref> [[http://www.uniprot.org/uniprot/KAR9_YEAST KAR9_YEAST]] Involved in karyogamy. Component of a cortical adaptor complex that orients cytoplasmic microtubules. It may be involved in anchoring cytoplasmic microtubules to the cell cortex.	+	[https://www.uniprot.org/uniprot/H0XPX6_OTOGA H0XPX6_OTOGA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5n74" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5n74" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[End-binding protein\|End-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Galago garnetti]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Kumar, A~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Steinmetz, M~~]]	+	[[Category: Kumar A]]
-	[[Category: ~~Microtubule binding protein]]~~	+	[[Category: Steinmetz M]]
-	~~[[Category: Microtubule end binding protein complex~~]]	+

OCA at 07:47, 11 March 2020

2020-03-11T07:47:33Z

←Older revision		Revision as of 07:47, 11 March 2020
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	==Microtubule end binding protein complex==		==Microtubule end binding protein complex==
-	<StructureSection load='5n74' size='340' side='right' caption='[[5n74]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='5n74' size='340' side='right'caption='[[5n74]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5n74]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Galago_garnetti Galago garnetti] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N74 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5n74]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Galago_garnetti Galago garnetti] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N74 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=30611 Galago garnetti])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=30611 Galago garnetti]), KAR9, YPL269W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n74 OCA], [http://pdbe.org/5n74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n74 RCSB], [http://www.ebi.ac.uk/pdbsum/5n74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n74 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n74 OCA], [http://pdbe.org/5n74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n74 RCSB], [http://www.ebi.ac.uk/pdbsum/5n74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n74 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MARE1_HUMAN MARE1_HUMAN]] Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.<ref>PMID:12388762</ref> <ref>PMID:21646404</ref> <ref>PMID:16109370</ref> <ref>PMID:19632184</ref> [[http://www.uniprot.org/uniprot/KAR9_YEAST KAR9_YEAST]] Involved in karyogamy. Component of a cortical adaptor complex that orients cytoplasmic microtubules. It may be involved in anchoring cytoplasmic microtubules to the cell cortex.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Galago garnetti]]		[[Category: Galago garnetti]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Kumar, A]]		[[Category: Kumar, A]]
	[[Category: Steinmetz, M]]		[[Category: Steinmetz, M]]
	[[Category: Microtubule binding protein]]		[[Category: Microtubule binding protein]]
	[[Category: Microtubule end binding protein complex]]		[[Category: Microtubule end binding protein complex]]

OCA at 09:51, 16 November 2017

2017-11-16T09:51:58Z

←Older revision		Revision as of 09:51, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5n74 is ~~ON HOLD until sometime~~ in the ~~future~~	+	==Microtubule end binding protein complex==
		+	<StructureSection load='5n74' size='340' side='right' caption='[[5n74]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5n74]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Galago_garnetti Galago garnetti] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N74 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAPRE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=30611 Galago garnetti])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n74 OCA], [http://pdbe.org/5n74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n74 RCSB], [http://www.ebi.ac.uk/pdbsum/5n74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n74 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Microtubule plus-end tracking proteins (+TIPs) are involved in virtually all microtubule-based processes. End-binding (EB) proteins are considered master regulators of +TIP interaction networks, since they autonomously track growing microtubule ends and recruit a plethora of proteins to this location. Two major EB-interacting elements have been described: CAP-Gly domains and linear SxIP sequence motifs. Here, we identified LxxPTPh as a third EB-binding motif that enables major +TIPs to interact with EBs at microtubule ends. In contrast to EB-SxIP and EB-CAP-Gly, the EB-LxxPTPh binding mode does not depend on the C-terminal tail region of EB. Our study reveals that +TIPs developed additional strategies besides CAP-Gly and SxIP to target EBs at growing microtubule ends. They further provide a unique basis to discover novel +TIPs, and to dissect the role of key interaction nodes and their differential regulation for hierarchical +TIP network organization and function in eukaryotic organisms.

-	~~Authors~~:	+	Short Linear Sequence Motif LxxPTPh Targets Diverse Proteins to Growing Microtubule Ends.,Kumar A, Manatschal C, Rai A, Grigoriev I, Degen MS, Jaussi R, Kretzschmar I, Prota AE, Volkmer R, Kammerer RA, Akhmanova A, Steinmetz MO Structure. 2017 Jun 6;25(6):924-932.e4. doi: 10.1016/j.str.2017.04.010. Epub 2017, May 25. PMID:28552577<ref>PMID:28552577</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5n74" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Galago garnetti]]
		+	[[Category: Human]]
		+	[[Category: Kumar, A]]
		+	[[Category: Steinmetz, M]]
		+	[[Category: Microtubule binding protein]]
		+	[[Category: Microtubule end binding protein complex]]

OCA: Protected "5n74" [edit=sysop:move=sysop]

2017-03-09T12:12:10Z

Protected "5n74" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:12, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5n74 is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

2017-03-09T12:12:08Z

New page: '''Unreleased structure''' The entry 5n74 is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5n74 is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]