5n8y - Revision history

OCA at 12:37, 15 November 2023

2023-11-15T12:37:13Z

←Older revision		Revision as of 12:37, 15 November 2023
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	<SX load='5n8y' size='340' side='right' viewer='molstar' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>		<SX load='5n8y' size='340' side='right' viewer='molstar' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Pcc_6301 Pcc 6301~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=32046 PCC 6301]), kaiB, Synpcc7942_1217, see0010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiA, Synpcc7942_1218, see0009 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301])</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.7Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase~~]~~, with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2~~.7~~.11.1 2.7.11.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [https://pdbe.org/5n8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [https://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [~~http~~://pdbe.org/5n8y PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref> [[http://www.uniprot.org/uniprot/KAIA_SYNE7 KAIA_SYNE7]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.<ref>PMID:12391300</ref> <ref>PMID:12727878</ref> <ref>PMID:12727879</ref> <ref>PMID:9727980</ref> [[http://www.uniprot.org/uniprot/KAIB_SYNE7 KAIB_SYNE7]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead need the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.<ref>PMID:9727980</ref> <ref>PMID:12727878</ref> <ref>PMID:12727879</ref> <ref>PMID:14709675</ref>	+	[https://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Non-specific serine/threonine protein kinase]]~~	+	[[Category: Synechococcus elongatus]]
-	~~[[Category: Pcc 6301~~]]	+	[[Category: Foerster F]]
-	[[Category: Foerster, F]]	+	[[Category: Heck AJR]]
-	[[Category: Heck~~, A J.R~~]]	+	[[Category: Loessl P]]
-	[[Category: Loessl, P]]	+	[[Category: Schuller JM]]
-	[[Category: Schuller~~, J M~~]]	+	[[Category: Snijder J]]
-	[[Category: Snijder, J]]	+
-	~~[[Category: Aaa+-atpase]]~~	+
-	~~[[Category: Circadian clock complex]]~~	+
-	~~[[Category: Cyanobacteria]]~~	+
-	~~[[Category: Fold-switch]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 21:11, 10 April 2020

2020-04-10T21:11:15Z

←Older revision		Revision as of 21:11, 10 April 2020
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	<SX load='5n8y' size='340' side='right' viewer='molstar' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>		<SX load='5n8y' size='340' side='right' viewer='molstar' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiB, Synpcc7942_1217, see0010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiA, Synpcc7942_1218, see0009 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiB, Synpcc7942_1217, see0010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiA, Synpcc7942_1218, see0009 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [http://pdbe.org/5n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [http://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [http://pdbe.org/5n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [http://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 19:14, 6 March 2020

2020-03-06T19:14:02Z

←Older revision		Revision as of 19:14, 6 March 2020
Line 1:		Line 1:

	==KaiCBA circadian clock backbone model based on a Cryo-EM density==		==KaiCBA circadian clock backbone model based on a Cryo-EM density==
-	<~~StructureSection~~ load='5n8y' size='340' side='right'caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<SX load='5n8y' size='340' side='right' viewer='molstar' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 07:43, 23 October 2019

2019-10-23T07:43:38Z

←Older revision		Revision as of 07:43, 23 October 2019
Line 1:		Line 1:

	==KaiCBA circadian clock backbone model based on a Cryo-EM density==		==KaiCBA circadian clock backbone model based on a Cryo-EM density==
-	<StructureSection load='5n8y' size='340' side='right' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>	+	<StructureSection load='5n8y' size='340' side='right'caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>		<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Circadian clock protein\|Circadian clock protein]]	+	*[[Circadian clock protein 3D structures\|Circadian clock protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Pcc 6301]]		[[Category: Pcc 6301]]

OCA at 06:30, 24 October 2018

2018-10-24T06:30:05Z

←Older revision		Revision as of 06:30, 24 October 2018
Line 3:		Line 3:
	<StructureSection load='5n8y' size='340' side='right' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>		<StructureSection load='5n8y' size='340' side='right' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kaiC, Synpcc7942_1216, see0011 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiB, Synpcc7942_1217, see0010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301]), kaiA, Synpcc7942_1218, see0009 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 PCC 6301])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [http://pdbe.org/5n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [http://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [http://pdbe.org/5n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [http://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>
	</table>		</table>
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5n8y" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5n8y" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Circadian clock protein\|Circadian clock protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Pcc 6301]]
	[[Category: Foerster, F]]		[[Category: Foerster, F]]
	[[Category: Heck, A J.R]]		[[Category: Heck, A J.R]]

OCA at 13:47, 29 March 2017

2017-03-29T13:47:58Z

←Older revision		Revision as of 13:47, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5n8y is ~~ON HOLD~~	+	==KaiCBA circadian clock backbone model based on a Cryo-EM density==
		+	<StructureSection load='5n8y' size='340' side='right' caption='[[5n8y]], [[Resolution\|resolution]] 4.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5n8y]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N8Y FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8y OCA], [http://pdbe.org/5n8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8y RCSB], [http://www.ebi.ac.uk/pdbsum/5n8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8y ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KAIC_SYNE7 KAIC_SYNE7]] Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.<ref>PMID:9727980</ref> <ref>PMID:14709675</ref> [[http://www.uniprot.org/uniprot/KAIA_SYNE7 KAIA_SYNE7]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation.<ref>PMID:12391300</ref> <ref>PMID:12727878</ref> <ref>PMID:12727879</ref> <ref>PMID:9727980</ref> [[http://www.uniprot.org/uniprot/KAIB_SYNE7 KAIB_SYNE7]] Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead need the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC.<ref>PMID:9727980</ref> <ref>PMID:12727878</ref> <ref>PMID:12727879</ref> <ref>PMID:14709675</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyanobacteria have a robust circadian oscillator, known as the Kai system. Reconstituted from the purified protein components KaiC, KaiB, and KaiA, it can tick autonomously in the presence of adenosine 5'-triphosphate (ATP). The KaiC hexamers enter a natural 24-hour reaction cycle of autophosphorylation and assembly with KaiB and KaiA in numerous diverse forms. We describe the preparation of stoichiometrically well-defined assemblies of KaiCB and KaiCBA, as monitored by native mass spectrometry, allowing for a structural characterization by single-particle cryo-electron microscopy and mass spectrometry. Our data reveal details of the interactions between the Kai proteins and provide a structural basis to understand periodic assembly of the protein oscillator.

-	~~Authors: Schuller, J.M~~., Snijder, J., ~~Loessl~~, P., ~~Heck~~, A.J.R., ~~Foerster, F~~.	+	Structures of the cyanobacterial circadian oscillator frozen in a fully assembled state.,Snijder J, Schuller JM, Wiegard A, Lossl P, Schmelling N, Axmann IM, Plitzko JM, Forster F, Heck AJ Science. 2017 Mar 17;355(6330):1181-1184. doi: 10.1126/science.aag3218. Epub 2017, Mar 16. PMID:28302852<ref>PMID:28302852</ref>

-	~~Description: KaiCBA circadian clock backbone model based on~~ a ~~Cryo-EM density~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Snijder, J]]~~	+	<div class="pdbe-citations 5n8y" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Heck, A.J.R~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Non-specific serine/threonine protein kinase]]
	[[Category: Foerster, F]]		[[Category: Foerster, F]]
		+	[[Category: Heck, A J.R]]
	[[Category: Loessl, P]]		[[Category: Loessl, P]]
-	[[Category: Schuller, J.M]]	+	[[Category: Schuller, J M]]
		+	[[Category: Snijder, J]]
		+	[[Category: Aaa+-atpase]]
		+	[[Category: Circadian clock complex]]
		+	[[Category: Cyanobacteria]]
		+	[[Category: Fold-switch]]
		+	[[Category: Kinase]]
		+	[[Category: Transferase]]

OCA: Protected "5n8y" [edit=sysop:move=sysop]

2017-03-09T12:17:38Z

Protected "5n8y" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:17, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5n8y is ON HOLD Authors: Schuller, J.M., Snijder, J., Loessl, P., Heck, A.J.R., Foerster, F. Description: KaiCBA circadian clock backbone model bas...

2017-03-09T12:17:36Z

New page: '''Unreleased structure''' The entry 5n8y is ON HOLD Authors: Schuller, J.M., Snijder, J., Loessl, P., Heck, A.J.R., Foerster, F. Description: KaiCBA circadian clock backbone model bas...

New page

'''Unreleased structure'''

The entry 5n8y is ON HOLD

Authors: Schuller, J.M., Snijder, J., Loessl, P., Heck, A.J.R., Foerster, F.

Description: KaiCBA circadian clock backbone model based on a Cryo-EM density
[[Category: Unreleased Structures]]
[[Category: Snijder, J]]
[[Category: Heck, A.J.R]]
[[Category: Foerster, F]]
[[Category: Loessl, P]]
[[Category: Schuller, J.M]]