5ngn - Revision history

OCA at 12:56, 15 November 2023

2023-11-15T12:56:03Z

←Older revision		Revision as of 12:56, 15 November 2023
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	<StructureSection load='5ngn' size='340' side='right'caption='[[5ngn]], [[Resolution\|resolution]] 1.48Å' scene=''>		<StructureSection load='5ngn' size='340' side='right'caption='[[5ngn]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NGN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.48Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [~~http~~://pdbe.org/5ngn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [https://pdbe.org/5ngn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [https://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2D0TC93_LYCBA A0A2D0TC93_LYCBA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lycium barbarum]]		[[Category: Lycium barbarum]]
-	[[Category: Hilgenfeld, R]]	+	[[Category: Hilgenfeld R]]
-	[[Category: Lei, J]]	+	[[Category: Lei J]]
-	[[Category: Sakai, N]]	+	[[Category: Sakai N]]
-	[[Category: Tan~~, W L]]~~	+	[[Category: Tan WL]]
-	~~[[Category: Cysteine-rich peptide]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Pi-helix]]~~	+
-	~~[[Category: Plant protein]]~~	+
-	~~[[Category: Wolfberry~~]]	+

OCA at 12:04, 26 August 2020

2020-08-26T12:04:10Z

←Older revision		Revision as of 12:04, 26 August 2020
Line 1:		Line 1:

	==Lybatide 2, a cystine-rich peptide from Lycium barbarum==		==Lybatide 2, a cystine-rich peptide from Lycium barbarum==
-	<StructureSection load='5ngn' size='340' side='right' caption='[[5ngn]], [[Resolution\|resolution]] 1.48Å' scene=''>	+	<StructureSection load='5ngn' size='340' side='right'caption='[[5ngn]], [[Resolution\|resolution]] 1.48Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NGN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NGN FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [http://pdbe.org/5ngn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [http://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [http://pdbe.org/5ngn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [http://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lycium barbarum]]		[[Category: Lycium barbarum]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]

OCA at 04:43, 16 November 2017

2017-11-16T04:43:52Z

←Older revision		Revision as of 04:43, 16 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ngn is ~~ON HOLD until Paper~~ Publication	+	==Lybatide 2, a cystine-rich peptide from Lycium barbarum==
		+	<StructureSection load='5ngn' size='340' side='right' caption='[[5ngn]], [[Resolution\|resolution]] 1.48Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ngn]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lycium_barbarum Lycium barbarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NGN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NGN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ngn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ngn OCA], [http://pdbe.org/5ngn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ngn RCSB], [http://www.ebi.ac.uk/pdbsum/5ngn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ngn ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cysteine-rich peptides (CRPs) of 2-6 kDa are generally thermally and proteolytically stable because of their multiple cross-bracing disulfide bonds. Here, we report the discovery and characterization of two novel cystine-stapled CRPs, designated lybatide 1 and 2 (lyba1 and lyba2), from the cortex of Lycium barbarum root. Lybatides, 32 to 33 amino acids in length, are hyperstable and display a novel disulfide connectivity with a cysteine motif of C-C-C-C-CC-CC which contains two pairs of adjacent cysteines (-CC-CC). X-ray structure analysis revealed the presence of a single cystine-stabilized (alpha + pi)-helix in lyba2, a rare feature of CRPs. Together, our results suggest that lybatides, one of the smallest four-disulfide-constrained plant CRPs, is a new family of CRPs. Additionally, this study provides new insights into the molecular diversity of plant cysteine-rich peptides and the unusual lybatide scaffold could be developed as a useful template for peptide engineering and therapeutic development.

-	~~Authors: Lei, J~~., Tan, ~~W.L.~~, ~~Sakai~~, N., ~~Hilgenfeld~~, R.	+	Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold.,Tan WL, Wong KH, Lei J, Sakai N, Tan HW, Hilgenfeld R, Tam JP Sci Rep. 2017 Jul 12;7(1):5194. doi: 10.1038/s41598-017-05037-1. PMID:28701689<ref>PMID:28701689</ref>

-	~~Description: Lybatide 2~~, a ~~cystine~~-~~rich peptide from Lycium barbarum~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ngn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Lycium barbarum]]
	[[Category: Hilgenfeld, R]]		[[Category: Hilgenfeld, R]]
-	[[Category: Sakai, N]]
-	[[Category: Tan, W.L]]
	[[Category: Lei, J]]		[[Category: Lei, J]]
		+	[[Category: Sakai, N]]
		+	[[Category: Tan, W L]]
		+	[[Category: Cysteine-rich peptide]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Pi-helix]]
		+	[[Category: Plant protein]]
		+	[[Category: Wolfberry]]

OCA: Protected "5ngn" [edit=sysop:move=sysop]

2017-04-05T10:06:12Z

Protected "5ngn" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:06, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5ngn is ON HOLD until Paper Publication Authors: Lei, J., Tan, W.L., Sakai, N., Hilgenfeld, R. Description: Lybatide 2, a cystine-rich peptide from...

2017-04-05T10:06:11Z

New page: '''Unreleased structure''' The entry 5ngn is ON HOLD until Paper Publication Authors: Lei, J., Tan, W.L., Sakai, N., Hilgenfeld, R. Description: Lybatide 2, a cystine-rich peptide from...

New page

'''Unreleased structure'''

The entry 5ngn is ON HOLD until Paper Publication

Authors: Lei, J., Tan, W.L., Sakai, N., Hilgenfeld, R.

Description: Lybatide 2, a cystine-rich peptide from Lycium barbarum
[[Category: Unreleased Structures]]
[[Category: Hilgenfeld, R]]
[[Category: Sakai, N]]
[[Category: Tan, W.L]]
[[Category: Lei, J]]