5njo - Revision history

OCA at 13:01, 15 November 2023

2023-11-15T13:01:47Z

←Older revision		Revision as of 13:01, 15 November 2023
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	<StructureSection load='5njo' size='340' side='right'caption='[[5njo]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='5njo' size='340' side='right'caption='[[5njo]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5njo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5NJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5njo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coeruleorubidus Streptomyces coeruleorubidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NJO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5njo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njo OCA], [~~http~~://pdbe.org/5njo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5njo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5njo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5njo ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5njo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njo OCA], [https://pdbe.org/5njo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5njo RCSB], [https://www.ebi.ac.uk/pdbsum/5njo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5njo ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/E2EKP5_STRC4 E2EKP5_STRC4]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bent, A F~~]]	+	[[Category: Streptomyces coeruleorubidus]]
-	[[Category: ~~Goss, R J.M~~]]	+	[[Category: Bent AF]]
-	[[Category: ~~Michailidou, F~~]]	+	[[Category: Goss RJM]]
-	[[Category: ~~Naismith, J H~~]]	+	[[Category: Michailidou F]]
-	[[Category: ~~Pac13 cupin pacidamycin]]~~	+	[[Category: Naismith JH]]
-	~~[[Category: Structural protein~~]]	+

OCA at 12:06, 26 August 2020

2020-08-26T12:06:30Z

←Older revision		Revision as of 12:06, 26 August 2020
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	==Roll out the beta-barrel: structure and mechanism of Pac13, a unique nucleoside dehydratase==		==Roll out the beta-barrel: structure and mechanism of Pac13, a unique nucleoside dehydratase==
-	<StructureSection load='5njo' size='340' side='right' caption='[[5njo]], [[Resolution\|resolution]] 1.55Å' scene=''>	+	<StructureSection load='5njo' size='340' side='right'caption='[[5njo]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5njo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJO OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5NJO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5njo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJO OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NJO FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5njo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njo OCA], [http://pdbe.org/5njo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njo RCSB], [http://www.ebi.ac.uk/pdbsum/5njo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njo ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5njo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njo OCA], [http://pdbe.org/5njo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njo RCSB], [http://www.ebi.ac.uk/pdbsum/5njo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njo ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Bent, A F]]		[[Category: Bent, A F]]
	[[Category: Goss, R J.M]]		[[Category: Goss, R J.M]]

OCA at 06:29, 28 March 2018

2018-03-28T06:29:02Z

←Older revision		Revision as of 06:29, 28 March 2018
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-	'''Unreleased structure'''

-	~~The entry~~ 5njo is ~~ON HOLD until Paper~~ Publication	+	==Roll out the beta-barrel: structure and mechanism of Pac13, a unique nucleoside dehydratase==
		+	<StructureSection load='5njo' size='340' side='right' caption='[[5njo]], [[Resolution\|resolution]] 1.55Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5njo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJO FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5njo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njo OCA], [http://pdbe.org/5njo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njo RCSB], [http://www.ebi.ac.uk/pdbsum/5njo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njo ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The uridyl peptide antibiotics (UPAs), of which pacidamycin is a member, have a clinically unexploited mode of action and an unusual assembly. Perhaps the most striking feature of these molecules is the biosynthetically unique 3'-deoxyuridine that they share. This moiety is generated by an unusual, small and monomeric dehydratase, Pac13, which catalyses the dehydration of uridine-5'-aldehyde. Here we report the structural characterisation of Pac13 with a series of ligands, and gain insight into the enzyme's mechanism demonstrating that H42 is critical to the enzyme's activity and that the reaction is likely to proceed via an E1cB mechanism. The resemblance of the 3'-deoxy pacidamycin moiety with the synthetic anti-retrovirals, presents a potential opportunity for the utilisation of Pac13 in the biocatalytic generation of antiviral compounds.

-	~~Authors~~: ~~Michailidou~~, F., ~~Bent, A.~~F., Naismith, ~~J.H.~~, ~~Goss~~, R.J.M.	+	Short and Sweet: Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'- Deoxy Nucleoside of Pacidamycins.,Michailidou F, Chung CW, Brown MJB, Bent AF, Naismith JH, Leavens WJ, Lynn SM, Sharma SV, Goss RJM Angew Chem Int Ed Engl. 2017 Aug 8. doi: 10.1002/anie.201705639. PMID:28786545<ref>PMID:28786545</ref>

-	~~Description: Roll out the beta-barrel: structure and mechanism of Pac13~~, a ~~unique nucleoside dehydratase~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Naismith~~, ~~J.H~~]]	+	<div class="pdbe-citations 5njo" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Bent~~, A.F]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bent, A F]]
		+	[[Category: Goss, R J.M]]
	[[Category: Michailidou, F]]		[[Category: Michailidou, F]]
-	[[Category: ~~Goss~~, R.J.M]]	+	[[Category: Naismith, J H]]
		+	[[Category: Pac13 cupin pacidamycin]]
		+	[[Category: Structural protein]]

OCA: Protected "5njo" [edit=sysop:move=sysop]

2017-04-05T10:13:45Z

Protected "5njo" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:13, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5njo is ON HOLD until Paper Publication Authors: Michailidou, F., Bent, A.F., Naismith, J.H., Goss, R.J.M. Description: Roll out the beta-barrel: s...

2017-04-05T10:13:44Z

New page: '''Unreleased structure''' The entry 5njo is ON HOLD until Paper Publication Authors: Michailidou, F., Bent, A.F., Naismith, J.H., Goss, R.J.M. Description: Roll out the beta-barrel: s...

New page

'''Unreleased structure'''

The entry 5njo is ON HOLD until Paper Publication

Authors: Michailidou, F., Bent, A.F., Naismith, J.H., Goss, R.J.M.

Description: Roll out the beta-barrel: structure and mechanism of Pac13, a unique nucleoside dehydratase
[[Category: Unreleased Structures]]
[[Category: Naismith, J.H]]
[[Category: Bent, A.F]]
[[Category: Michailidou, F]]
[[Category: Goss, R.J.M]]