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5oe2 - Revision history
2026-04-13T11:51:59Z
Revision history for this page on the wiki
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http://52.214.119.220/wiki/index.php?title=5oe2&diff=3990618&oldid=prev
OCA at 16:46, 13 December 2023
2023-12-13T16:46:25Z
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 16:46, 13 December 2023</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>==CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='5oe2' size='340' side='right' caption='[[5oe2]], [[Resolution|resolution]] 2.20&Aring;' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='5oe2' size='340' side='right'caption='[[5oe2]], [[Resolution|resolution]] 2.20&Aring;' scene=''></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5oe2]] is a 4 chain structure with sequence from [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://en.wikipedia.org/wiki/<del style="color: red; font-weight: bold; text-decoration: none;">"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus </del>pneumoniae<del style="color: red; font-weight: bold; text-decoration: none;">" (schroeter 1886) flugge 1886</del>]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OE2 OCA]. For a <b>guided tour on the structure components</b> use [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://<del style="color: red; font-weight: bold; text-decoration: none;">oca</del>.<del style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=5OE2 FirstGlance]. <br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5oe2]] is a 4 chain structure with sequence from [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://en.wikipedia.org/wiki/<ins style="color: red; font-weight: bold; text-decoration: none;">Klebsiella_pneumoniae Klebsiella </ins>pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OE2 OCA]. For a <b>guided tour on the structure components</b> use [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://<ins style="color: red; font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=5OE2 FirstGlance]. <br></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></td></tr><tr id='<del style="color: red; font-weight: bold; text-decoration: none;">ligand</del>'><td class="sblockLbl"><b>[[<del style="color: red; font-weight: bold; text-decoration: none;">Ligand</del>|<del style="color: red; font-weight: bold; text-decoration: none;">Ligands</del>:]]</b></td><td class="sblockDat"<del style="color: red; font-weight: bold; text-decoration: none;">><scene name</del>=<del style="color: red; font-weight: bold; text-decoration: none;">'pdbligand=CL:CHLORIDE+ION'>CL</scene</del>>, <del style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></del></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></td></tr><tr id='<ins style="color: red; font-weight: bold; text-decoration: none;">method</ins>'><td class="sblockLbl"><b>[[<ins style="color: red; font-weight: bold; text-decoration: none;">Empirical_models</ins>|<ins style="color: red; font-weight: bold; text-decoration: none;">Method</ins>:]]</b></td><td class="sblockDat" <ins style="color: red; font-weight: bold; text-decoration: none;">id</ins>=<ins style="color: red; font-weight: bold; text-decoration: none;">"methodDat"</ins>><ins style="color: red; font-weight: bold; text-decoration: none;">X-ray diffraction</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[[Resolution|Resolution]] 2.2&#8491;</ins></td></tr></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><tr id='<del style="color: red; font-weight: bold; text-decoration: none;">NonStdRes</del>'><td class="sblockLbl"><b>[[<del style="color: red; font-weight: bold; text-decoration: none;">Non-Standard_Residue</del>|<del style="color: red; font-weight: bold; text-decoration: none;">NonStd Res</del>:]]</b></td><td class="sblockDat"><scene name='pdbligand=<del style="color: red; font-weight: bold; text-decoration: none;">KCX</del>:<del style="color: red; font-weight: bold; text-decoration: none;">LYSINE</del>+<del style="color: red; font-weight: bold; text-decoration: none;">NZ-CARBOXYLIC+ACID</del>'><del style="color: red; font-weight: bold; text-decoration: none;">KCX</del></scene><<del style="color: red; font-weight: bold; text-decoration: none;">/td></tr></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='<ins style="color: red; font-weight: bold; text-decoration: none;">ligand</ins>'><td class="sblockLbl"><b>[[<ins style="color: red; font-weight: bold; text-decoration: none;">Ligand</ins>|<ins style="color: red; font-weight: bold; text-decoration: none;">Ligands</ins>:]]</b></td><td class="sblockDat<ins style="color: red; font-weight: bold; text-decoration: none;">" id="ligandDat</ins>"><scene name='pdbligand=<ins style="color: red; font-weight: bold; text-decoration: none;">CL</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">CHLORIDE</ins>+<ins style="color: red; font-weight: bold; text-decoration: none;">ION</ins>'><ins style="color: red; font-weight: bold; text-decoration: none;">CL</ins></scene><ins style="color: red; font-weight: bold; text-decoration: none;">, </ins><<ins style="color: red; font-weight: bold; text-decoration: none;">scene name</ins>='<ins style="color: red; font-weight: bold; text-decoration: none;">pdbligand</ins>=<ins style="color: red; font-weight: bold; text-decoration: none;">KCX</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">LYSINE+NZ</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">CARBOXYLIC+ACID'</ins>><ins style="color: red; font-weight: bold; text-decoration: none;">KCX</ins></<ins style="color: red; font-weight: bold; text-decoration: none;">scene</ins>><ins style="color: red; font-weight: bold; text-decoration: none;">, </ins><<ins style="color: red; font-weight: bold; text-decoration: none;">scene name</ins>='<ins style="color: red; font-weight: bold; text-decoration: none;">pdbligand</ins>=<ins style="color: red; font-weight: bold; text-decoration: none;">NA</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">SODIUM+ION</ins>'><ins style="color: red; font-weight: bold; text-decoration: none;">NA</ins></<ins style="color: red; font-weight: bold; text-decoration: none;">scene</ins>></td></tr></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><tr id</del>='<del style="color: red; font-weight: bold; text-decoration: none;">gene'><td class</del>=<del style="color: red; font-weight: bold; text-decoration: none;">"sblockLbl"><b>[[Gene|Gene</del>:<del style="color: red; font-weight: bold; text-decoration: none;">]]</b></td><td class="sblockDat">blaOXA</del>-<del style="color: red; font-weight: bold; text-decoration: none;">245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td</del>></<del style="color: red; font-weight: bold; text-decoration: none;">tr</del>></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://<ins style="color: red; font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=5oe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oe2 OCA], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://pdbe.org/5oe2 PDBe], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.rcsb.org/pdb/explore.do?structureId=5oe2 RCSB], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.ebi.ac.uk/pdbsum/5oe2 PDBsum], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://prosat.h-its.org/prosat/prosatexe?pdbcode=5oe2 ProSAT]</span></td></tr></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><<del style="color: red; font-weight: bold; text-decoration: none;">tr id</del>='<del style="color: red; font-weight: bold; text-decoration: none;">activity'><td class</del>=<del style="color: red; font-weight: bold; text-decoration: none;">"sblockLbl"><b>Activity</del>:<del style="color: red; font-weight: bold; text-decoration: none;"></b></td><td class="sblockDat"><span class='plainlinks</del>'><del style="color: red; font-weight: bold; text-decoration: none;">[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </del></<del style="color: red; font-weight: bold; text-decoration: none;">span</del>></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://<del style="color: red; font-weight: bold; text-decoration: none;">oca</del>.<del style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=5oe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oe2 OCA], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://pdbe.org/5oe2 PDBe], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.rcsb.org/pdb/explore.do?structureId=5oe2 RCSB], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.ebi.ac.uk/pdbsum/5oe2 PDBsum], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://prosat.h-its.org/prosat/prosatexe?pdbcode=5oe2 ProSAT]</span></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Function ==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[https://www.uniprot.org/uniprot/L7V1I2_KLEPN L7V1I2_KLEPN] </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="background-color:#fffaf0;"></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div style="background-color:#fffaf0;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Publication Abstract from PubMed ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Publication Abstract from PubMed ==</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div class="pdbe-citations 5oe2" style="background-color:#fffaf0;"></div></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><div class="pdbe-citations 5oe2" style="background-color:#fffaf0;"></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==See Also==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Beta-lactamase</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Klebsiella pneumoniae</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Leiros, H K.S</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large Structures</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Lund, B A</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Leiros HKS</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Antibiotic]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Lund BA</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Antibiotic resistance]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Carbapenemase]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Oxa-48-like]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Oxacillinase</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=5oe2&diff=2799324&oldid=prev
OCA at 06:14, 1 November 2017
2017-11-01T06:14:49Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 06:14, 1 November 2017</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='5oe2' size='340' side='right' caption='[[5oe2]], [[Resolution|resolution]] 2.20&Aring;' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='5oe2' size='340' side='right' caption='[[5oe2]], [[Resolution|resolution]] 2.20&Aring;' scene=''></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5oe2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OE2 FirstGlance]. <br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5oe2]] is a 4 chain structure <ins style="color: red; font-weight: bold; text-decoration: none;">with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]</ins>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OE2 FirstGlance]. <br></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaOXA-245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oe2 OCA], [http://pdbe.org/5oe2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oe2 RCSB], [http://www.ebi.ac.uk/pdbsum/5oe2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oe2 ProSAT]</span></td></tr></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oe2 OCA], [http://pdbe.org/5oe2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oe2 RCSB], [http://www.ebi.ac.uk/pdbsum/5oe2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oe2 ProSAT]</span></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><div style="background-color:#fffaf0;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Publication Abstract from PubMed ==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The first crystal structures of the class D beta-lactamases OXA-181 and OXA-245 were determined to 2.05 and 2.20 A resolution, respectively; in addition, the structure of a new crystal form of OXA-163 was resolved to 2.07 A resolution. All of these enzymes are OXA-48-like and have been isolated from different clinical Klebsiella pneumoniae strains and also from other human pathogens such as Pseudomonas aeruginosa and Escherichia coli. Here, enzyme kinetics and thermostability studies are presented, and the new crystal structures are used to explain the observed variations. OXA-245 had the highest melting point (Tm = 55.8 degrees C), as determined by differential scanning calorimetry, compared with OXA-163 (Tm = 49.4 degrees C) and OXA-181 (Tm = 52.6 degrees C). The differences could be explained by the loss of two salt bridges in OXA-163, and an overall decrease in the polarity of the surface of OXA-181 compared with OXA-245.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.,Lund BA, Thomassen AM, Carlsen TJO, Leiros HKS Acta Crystallogr F Struct Biol Commun. 2017 Oct 1;73(Pt 10):579-587. doi:, 10.1107/S2053230X17013838. Epub 2017 Oct 2. PMID:28994407<ref>PMID:28994407</ref></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><div class="pdbe-citations 5oe2" style="background-color:#fffaf0;"></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><references/></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=5oe2&diff=2788216&oldid=prev
OCA: Protected "5oe2" [edit=sysop:move=sysop]
2017-10-12T15:07:26Z
<p>Protected "<a href="/wiki/index.php/5oe2" title="5oe2">5oe2</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 15:07, 12 October 2017</td>
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OCA
http://52.214.119.220/wiki/index.php?title=5oe2&diff=2788215&oldid=prev
OCA: New page: ==CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245== <StructureSection load='5oe2' size='340' side='right' caption='5oe2, resolution 2.20Å' scene=''> == Structural...
2017-10-12T15:07:24Z
<p>New page: ==CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245== <StructureSection load='5oe2' size='340' side='right' caption='<a href="/wiki/index.php/5oe2" title="5oe2">5oe2</a>, <a href="/wiki/index.php/Resolution" title="Resolution">resolution</a> 2.20&Aring;' scene=''> == Structural...</p>
<p><b>New page</b></p><div><br />
==CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245==<br />
<StructureSection load='5oe2' size='340' side='right' caption='[[5oe2]], [[Resolution|resolution]] 2.20&Aring;' scene=''><br />
== Structural highlights ==<br />
<table><tr><td colspan='2'>[[5oe2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OE2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OE2 FirstGlance]. <br><br />
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr><br />
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene></td></tr><br />
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr><br />
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oe2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oe2 OCA], [http://pdbe.org/5oe2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oe2 RCSB], [http://www.ebi.ac.uk/pdbsum/5oe2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oe2 ProSAT]</span></td></tr><br />
</table><br />
__TOC__<br />
</StructureSection><br />
[[Category: Beta-lactamase]]<br />
[[Category: Leiros, H K.S]]<br />
[[Category: Lund, B A]]<br />
[[Category: Antibiotic]]<br />
[[Category: Antibiotic resistance]]<br />
[[Category: Carbapenemase]]<br />
[[Category: Oxa-48-like]]<br />
[[Category: Oxacillinase]]</div>
OCA