5og9 - Revision history

OCA at 16:49, 13 December 2023

2023-12-13T16:49:02Z

←Older revision		Revision as of 16:49, 13 December 2023
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	<StructureSection load='5og9' size='340' side='right'caption='[[5og9]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='5og9' size='340' side='right'caption='[[5og9]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5og9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OG9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5og9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.09Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5og9 OCA], [~~http~~://pdbe.org/5og9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5og9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5og9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5og9 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5og9 OCA], [https://pdbe.org/5og9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5og9 RCSB], [https://www.ebi.ac.uk/pdbsum/5og9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5og9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~F2Q7T0_BACME F2Q7T0_BACME]~~] Functions as a fatty acid monooxygenase.~~[PIRNR~~:~~PIRNR000209]~~	+	[https://www.uniprot.org/uniprot/CPXB_PRIM2 CPXB_PRIM2] Functions as a fatty acid monooxygenase (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Catalyzes hydroxylation of fatty acids at omega-1, omega-2 and omega-3 positions (PubMed:1727637, PubMed:21875028). Shows activity toward medium and long-chain fatty acids, with optimum chain lengths of 12, 14 and 16 carbons (lauric, myristic, and palmitic acids). Able to metabolize some of these primary metabolites to secondary and tertiary products (PubMed:1727637). Marginal activity towards short chain lengths of 8-10 carbons (PubMed:1727637, PubMed:18619466). Hydroxylates highly branched fatty acids, which play an essential role in membrane fluidity regulation (PubMed:16566047). Also displays a NADPH-dependent reductase activity in the C-terminal domain, which allows electron transfer from NADPH to the heme iron of the cytochrome P450 N-terminal domain (PubMed:3106359, PubMed:1727637, PubMed:16566047, PubMed:7578081, PubMed:11695892, PubMed:14653735, PubMed:16403573, PubMed:18004886, PubMed:17077084, PubMed:17868686, PubMed:18298086, PubMed:18619466, PubMed:18721129, PubMed:19492389, PubMed:20180779, PubMed:21110374, PubMed:21875028). Involved in inactivation of quorum sensing signals of other competing bacteria by oxidazing efficiently acyl homoserine lactones (AHLs), molecules involved in quorum sensing signaling pathways, and their lactonolysis products acyl homoserines (AHs) (PubMed:18020460).<ref>PMID:11695892</ref> <ref>PMID:14653735</ref> <ref>PMID:16403573</ref> <ref>PMID:16566047</ref> <ref>PMID:17077084</ref> <ref>PMID:1727637</ref> <ref>PMID:17868686</ref> <ref>PMID:18004886</ref> <ref>PMID:18020460</ref> <ref>PMID:18298086</ref> <ref>PMID:18619466</ref> <ref>PMID:18721129</ref> <ref>PMID:19492389</ref> <ref>PMID:20180779</ref> <ref>PMID:21110374</ref> <ref>PMID:21875028</ref> <ref>PMID:3106359</ref> <ref>PMID:7578081</ref>

	==See Also==		==See Also==
	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]		*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Gamble, C~~]]	+	[[Category: Priestia megaterium]]
-	[[Category: ~~Leys, D~~]]	+	[[Category: Gamble C]]
-	[[Category: ~~Munro, A W~~]]	+	[[Category: Leys D]]
-	[[Category: ~~Cytochrome p450]]~~	+	[[Category: Munro AW]]
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Laboratory evolution]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Steroid]]~~	+
-	~~[[Category: Testosterone~~]]	+

OCA at 12:23, 26 August 2020

2020-08-26T12:23:08Z

←Older revision		Revision as of 12:23, 26 August 2020
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	==The BM3 mutant WIFI-WC heme domain in complex with testosterone==		==The BM3 mutant WIFI-WC heme domain in complex with testosterone==
-	<StructureSection load='5og9' size='340' side='right' caption='[[5og9]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='5og9' size='340' side='right'caption='[[5og9]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5og9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OG9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OG9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5og9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OG9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OG9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5og9 OCA], [http://pdbe.org/5og9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5og9 RCSB], [http://www.ebi.ac.uk/pdbsum/5og9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5og9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5og9 OCA], [http://pdbe.org/5og9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5og9 RCSB], [http://www.ebi.ac.uk/pdbsum/5og9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5og9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/F2Q7T0_BACME F2Q7T0_BACME]] Functions as a fatty acid monooxygenase.[PIRNR:PIRNR000209]		[[http://www.uniprot.org/uniprot/F2Q7T0_BACME F2Q7T0_BACME]] Functions as a fatty acid monooxygenase.[PIRNR:PIRNR000209]
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gamble, C]]		[[Category: Gamble, C]]
	[[Category: Leys, D]]		[[Category: Leys, D]]

OCA at 18:34, 1 August 2018

2018-08-01T18:34:45Z

←Older revision		Revision as of 18:34, 1 August 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5og9 is ~~ON HOLD~~	+	==The BM3 mutant WIFI-WC heme domain in complex with testosterone==
-		+	<StructureSection load='5og9' size='340' side='right' caption='[[5og9]], [[Resolution\|resolution]] 2.09Å' scene=''>
-	~~Authors~~: ~~Gamble~~, C., ~~Munro~~, A.W., ~~Leys~~, D.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5og9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OG9 FirstGlance]. <br>
-	~~Description~~: ~~The BM3 mutant WIFI-WC heme domain in complex with testosterone~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=TES:TESTOSTERONE'>TES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5og9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5og9 OCA], [http://pdbe.org/5og9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5og9 RCSB], [http://www.ebi.ac.uk/pdbsum/5og9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5og9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/F2Q7T0_BACME F2Q7T0_BACME]] Functions as a fatty acid monooxygenase.[PIRNR:PIRNR000209]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gamble, C]]
	[[Category: Leys, D]]		[[Category: Leys, D]]
-	[[Category: ~~Gamble~~, C]]	+	[[Category: Munro, A W]]
-	[[Category: ~~Munro, A.W~~]]	+	[[Category: Cytochrome p450]]
		+	[[Category: Hydroxylation]]
		+	[[Category: Laboratory evolution]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Steroid]]
		+	[[Category: Testosterone]]

OCA: Protected "5og9" [edit=sysop:move=sysop]

2017-09-27T12:23:48Z

Protected "5og9" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:23, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5og9 is ON HOLD Authors: Gamble, C., Munro, A.W., Leys, D. Description: The BM3 mutant WIFI-WC heme domain in complex with testosterone [[Category:...

2017-09-27T12:23:47Z

New page: '''Unreleased structure''' The entry 5og9 is ON HOLD Authors: Gamble, C., Munro, A.W., Leys, D. Description: The BM3 mutant WIFI-WC heme domain in complex with testosterone [[Category:...

New page

'''Unreleased structure'''

The entry 5og9 is ON HOLD

Authors: Gamble, C., Munro, A.W., Leys, D.

Description: The BM3 mutant WIFI-WC heme domain in complex with testosterone
[[Category: Unreleased Structures]]
[[Category: Leys, D]]
[[Category: Gamble, C]]
[[Category: Munro, A.W]]