5oss - Revision history

OCA at 12:59, 20 December 2023

2023-12-20T12:59:01Z

←Older revision		Revision as of 12:59, 20 December 2023
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	<StructureSection load='5oss' size='340' side='right'caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5oss' size='340' side='right'caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5OSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OSS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [~~http~~://pdbe.org/5oss PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5oss PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [https://pdbe.org/5oss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [https://www.ebi.ac.uk/pdbsum/5oss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BGLA_THEMA BGLA_THEMA]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-glucosidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Davies, G J~~]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: ~~Offen, W A~~]]	+	[[Category: Davies GJ]]
-	[[Category: ~~Overkleeft, H S~~]]	+	[[Category: Offen WA]]
-	[[Category: ~~Schroeder, S P~~]]	+	[[Category: Overkleeft HS]]
-	[[Category: ~~Glucoimidazole]]~~	+	[[Category: Schroeder SP]]
-	~~[[Category: Glycosylhydrolase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Thermotoga maritima~~]]	+

OCA at 07:31, 2 September 2020

2020-09-02T07:31:08Z

←Older revision		Revision as of 07:31, 2 September 2020
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	==Beta-glucosidase from Thermotoga maritima in complex with Gluco-1H-imidazole==		==Beta-glucosidase from Thermotoga maritima in complex with Gluco-1H-imidazole==
-	<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='5oss' size='340' side='right'caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5OSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OSS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5oss" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5oss" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-glucosidase 3D structures\|Beta-glucosidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 22:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
		+	[[Category: Large Structures]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Offen, W A]]		[[Category: Offen, W A]]

OCA at 06:27, 9 May 2018

2018-05-09T06:27:01Z

←Older revision		Revision as of 06:27, 9 May 2018
Line 1:		Line 1:

-	==~~Family 1 Glycoside Hydrolase~~ with ~~Inhibitor~~==	+	==Beta-glucosidase from Thermotoga maritima in complex with Gluco-1H-imidazole==
	<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Thema Thema]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OSS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bglA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>
Line 23:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
-	[[Category: Thema]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Offen, W A]]		[[Category: Offen, W A]]

OCA at 05:52, 25 April 2018

2018-04-25T05:52:23Z

←Older revision		Revision as of 05:52, 25 April 2018
Line 3:		Line 3:
	<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OSS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OSS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">bglA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>
Line 22:		Line 23:
	</StructureSection>		</StructureSection>
	[[Category: Beta-glucosidase]]		[[Category: Beta-glucosidase]]
		+	[[Category: Thema]]
	[[Category: Davies, G J]]		[[Category: Davies, G J]]
	[[Category: Offen, W A]]		[[Category: Offen, W A]]

OCA at 13:43, 11 April 2018

2018-04-11T13:43:20Z

←Older revision		Revision as of 13:43, 11 April 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5oss is ~~ON HOLD until Paper~~ Publication	+	==Family 1 Glycoside Hydrolase with Inhibitor==
		+	<StructureSection load='5oss' size='340' side='right' caption='[[5oss]], [[Resolution\|resolution]] 1.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5oss]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OSS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OSS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AEZ:(4~{S},5~{S},6~{R},7~{R})-7-(hydroxymethyl)-4,5,6,7-tetrahydro-1~{H}-benzimidazole-4,5,6-triol'>AEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucosidase Beta-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.21 3.2.1.21] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oss OCA], [http://pdbe.org/5oss PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oss RCSB], [http://www.ebi.ac.uk/pdbsum/5oss PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oss ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Gluco-azoles competitively inhibit glucosidases by transition-state mimicry and their ability to interact with catalytic acid residues in glucosidase active sites. We noted that no azole-type inhibitors described, to date, possess a protic nitrogen characteristic for 1 H-imidazoles. Here, we present gluco-1 H-imidazole, a gluco-azole bearing a 1 H-imidazole fused to a glucopyranose-configured cyclitol core, and three close analogues as new glucosidase inhibitors. All compounds inhibit human retaining beta-glucosidase, GBA1, with the most potent ones inhibiting this enzyme (deficient in Gaucher disease) on a par with glucoimidazole. None inhibit glucosylceramide synthase, cytosolic beta-glucosidase GBA2 or alpha-glucosidase GAA. Structural, physical and computational studies provide first insights into the binding mode of this conceptually new class of retaining beta-glucosidase inhibitors.

-	~~Authors~~:	+	Gluco-1 H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor.,Schroder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codee JDC, Davies GJ, Overkleeft HS J Am Chem Soc. 2018 Apr 4. doi: 10.1021/jacs.8b02399. PMID:29601200<ref>PMID:29601200</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5oss" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-glucosidase]]
		+	[[Category: Davies, G J]]
		+	[[Category: Offen, W A]]
		+	[[Category: Overkleeft, H S]]
		+	[[Category: Schroeder, S P]]
		+	[[Category: Glucoimidazole]]
		+	[[Category: Glycosylhydrolase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Thermotoga maritima]]

OCA: Protected "5oss" [edit=sysop:move=sysop]

2017-09-27T12:48:28Z

Protected "5oss" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:48, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5oss is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T12:48:27Z

New page: '''Unreleased structure''' The entry 5oss is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

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'''Unreleased structure'''

The entry 5oss is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]