5pzz - Revision history

OCA at 14:27, 24 January 2024

2024-01-24T14:27:43Z

←Older revision		Revision as of 14:27, 24 January 2024
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	==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea==		==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea==
-	<StructureSection load='5pzz' size='340' side='right' caption='[[5pzz]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5pzz' size='340' side='right'caption='[[5pzz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5pzz]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5PZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5pzz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5PZZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=94Y:N~~-[(5~~-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide'>94Y</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FBP1, hCG_1640493 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=94Y:N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide'>94Y</scene></td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Fructose~~-~~bisphosphatase Fructose-bisphosphatase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=3.~~1.3~~.11~~ 3.1~~.3.11]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzz OCA], [https://pdbe.org/5pzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5pzz RCSB], [https://www.ebi.ac.uk/pdbsum/5pzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzz OCA], [~~http~~://pdbe.org/5pzz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5pzz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5pzz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzz ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
		+
		+	==See Also==
		+	*[[Fructose-1%2C6-bisphosphatase 3D structures\|Fructose-1%2C6-bisphosphatase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fructose-bisphosphatase~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Human~~]]	+	[[Category: Large Structures]]
-	[[Category: Alker, A]]	+	[[Category: Alker A]]
-	[[Category: Banner, D]]	+	[[Category: Banner D]]
-	[[Category: Benz, J]]	+	[[Category: Benz J]]
-	[[Category: Burley~~, S K~~]]	+	[[Category: Burley SK]]
-	[[Category: Joseph, C]]	+	[[Category: Joseph C]]
-	[[Category: Kuhn, B]]	+	[[Category: Kuhn B]]
-	[[Category: Rudolph~~, M~~]]	+	[[Category: Rudolph MG]]
-	[[Category: Ruf, A]]	+	[[Category: Ruf A]]
-	[[Category: Shao, C]]	+	[[Category: Shao C]]
-	[[Category: Tetaz, T]]	+	[[Category: Tetaz T]]
-	[[Category: Yang, H]]	+	[[Category: Yang H]]
-	~~[[Category: D3r docking]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex~~]]	+

OCA at 12:22, 16 January 2019

2019-01-16T12:22:11Z

←Older revision		Revision as of 12:22, 16 January 2019
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	<StructureSection load='5pzz' size='340' side='right' caption='[[5pzz]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5pzz' size='340' side='right' caption='[[5pzz]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5pzz]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PZZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5pzz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PZZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=94Y:N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide'>94Y</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=94Y:N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide'>94Y</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FBP1, hCG_1640493 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzz OCA], [http://pdbe.org/5pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pzz RCSB], [http://www.ebi.ac.uk/pdbsum/5pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzz OCA], [http://pdbe.org/5pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pzz RCSB], [http://www.ebi.ac.uk/pdbsum/5pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzz ProSAT]</span></td></tr>
Line 11:		Line 12:
	</StructureSection>		</StructureSection>
	[[Category: Fructose-bisphosphatase]]		[[Category: Fructose-bisphosphatase]]
		+	[[Category: Human]]
	[[Category: Alker, A]]		[[Category: Alker, A]]
	[[Category: Banner, D]]		[[Category: Banner, D]]

OCA at 06:32, 9 January 2019

2019-01-09T06:32:35Z

←Older revision		Revision as of 06:32, 9 January 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5pzz is ON HOLD~~	+	==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea==
-		+	<StructureSection load='5pzz' size='340' side='right' caption='[[5pzz]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors: Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5pzz]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5PZZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5PZZ FirstGlance]. <br>
-	~~Description:~~ Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=94Y:N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-3,4-dichlorobenzene-1-sulfonamide'>94Y</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5pzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5pzz OCA], [http://pdbe.org/5pzz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5pzz RCSB], [http://www.ebi.ac.uk/pdbsum/5pzz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5pzz ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fructose-bisphosphatase]]
		+	[[Category: Alker, A]]
		+	[[Category: Banner, D]]
		+	[[Category: Benz, J]]
		+	[[Category: Burley, S K]]
		+	[[Category: Joseph, C]]
		+	[[Category: Kuhn, B]]
	[[Category: Rudolph, M]]		[[Category: Rudolph, M]]
	[[Category: Ruf, A]]		[[Category: Ruf, A]]
-	[[Category: ~~Burley~~, ~~S.K~~]]	+	[[Category: Shao, C]]
		+	[[Category: Tetaz, T]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
-	[[Category: ~~Joseph, C~~]]	+	[[Category: D3r docking]]
-	[[Category: ~~Tetaz, T]]~~	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
-	~~[[Category: Shao, C]]~~	+
-	~~[[Category: Alker, A]]~~	+
-	~~[[Category: Benz, J]]~~	+
-	~~[[Category: Kuhn, B]]~~	+
-	~~[[Category: Banner, D~~]]	+

OCA at 06:31, 26 December 2018

2018-12-26T06:31:33Z

←Older revision		Revision as of 06:31, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5pzz is ON HOLD ~~until sometime in the future~~	+	The entry 5pzz is ON HOLD

-	Authors: Ruf, A., ~~Herzog~~, M., Tetaz, T., Benz, J., Yang, H., Shao, C., Burley, S.K.	+	Authors: Ruf, A., Joseph, C., Alker, A., Banner, D., Tetaz, T., Benz, J., Kuhn, B., Rudolph, M., Yang, H., Shao, C., Burley, S.K.

-	Description: ~~Ligand binding to FRUCTOSE~~-1,6-~~BISPHOSPHATASE~~	+	Description: Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-(3,4-dichlorophenyl)sulfonylurea
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Rudolph, M]]
	[[Category: Ruf, A]]		[[Category: Ruf, A]]
-	[[Category: ~~Herzog~~, M]]	+	[[Category: Burley, S.K]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
		+	[[Category: Joseph, C]]
	[[Category: Tetaz, T]]		[[Category: Tetaz, T]]
-	[[Category: Burley, S.K]]
	[[Category: Shao, C]]		[[Category: Shao, C]]
		+	[[Category: Alker, A]]
	[[Category: Benz, J]]		[[Category: Benz, J]]
		+	[[Category: Kuhn, B]]
		+	[[Category: Banner, D]]

OCA at 13:02, 27 September 2017

2017-09-27T13:02:33Z

←Older revision		Revision as of 13:02, 27 September 2017
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ruf, A]]		[[Category: Ruf, A]]
-	[[Category: Burley, S.K]]
-	[[Category: Shao, C]]
-	[[Category: Benz, J]]
	[[Category: Herzog, M]]		[[Category: Herzog, M]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
	[[Category: Tetaz, T]]		[[Category: Tetaz, T]]
		+	[[Category: Burley, S.K]]
		+	[[Category: Shao, C]]
		+	[[Category: Benz, J]]

OCA at 12:31, 17 May 2017

2017-05-17T12:31:26Z

←Older revision		Revision as of 12:31, 17 May 2017
Line 3:		Line 3:
	The entry 5pzz is ON HOLD until sometime in the future		The entry 5pzz is ON HOLD until sometime in the future

-	Authors: Yang, H., Burley, S.K.	+	Authors: Ruf, A., Herzog, M., Tetaz, T., Benz, J., Yang, H., Shao, C., Burley, S.K.

	Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE		Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Ruf, A]]
	[[Category: Burley, S.K]]		[[Category: Burley, S.K]]
		+	[[Category: Shao, C]]
		+	[[Category: Benz, J]]
		+	[[Category: Herzog, M]]
	[[Category: Yang, H]]		[[Category: Yang, H]]
		+	[[Category: Tetaz, T]]

OCA at 09:33, 10 May 2017

2017-05-10T09:33:40Z

←Older revision		Revision as of 09:33, 10 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5pzz is ON HOLD	+	The entry 5pzz is ON HOLD until sometime in the future

	Authors: Yang, H., Burley, S.K.		Authors: Yang, H., Burley, S.K.

OCA at 08:16, 12 April 2017

2017-04-12T08:16:51Z

←Older revision		Revision as of 08:16, 12 April 2017
Line 3:		Line 3:
	The entry 5pzz is ON HOLD		The entry 5pzz is ON HOLD

-	Authors: Yang, ~~Huanwang~~	+	Authors: Yang, H., Burley, S.K.

	Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE		Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Yang, ~~Huanwang~~]]	+	[[Category: Burley, S.K]]
		+	[[Category: Yang, H]]

OCA: Protected "5pzz" [edit=sysop:move=sysop]

2017-04-05T10:19:58Z

Protected "5pzz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5pzz is ON HOLD Authors: Yang, Huanwang Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE Category: Unreleased Structures [[Category: ...

2017-04-05T10:19:57Z

New page: '''Unreleased structure''' The entry 5pzz is ON HOLD Authors: Yang, Huanwang Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 5pzz is ON HOLD

Authors: Yang, Huanwang

Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE
[[Category: Unreleased Structures]]
[[Category: Yang, Huanwang]]