5qj2 - Revision history

OCA at 08:56, 7 February 2024

2024-02-07T08:56:15Z

←Older revision		Revision as of 08:56, 7 February 2024
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-	====	+	==CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1H-PYRAZOL-3- YL)BENZYL)OXY)- 1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE==
-	<StructureSection load='5qj2' size='340' side='right'caption='[[5qj2]]' scene=''>	+	<StructureSection load='5qj2' size='340' side='right'caption='[[5qj2]], [[Resolution\|resolution]] 2.82Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qj2]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QJ2 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj2 OCA], [https://pdbe.org/5qj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj2 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.82Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JXS:7-{[3-(1-methyl-1H-pyrazol-3-yl)phenyl]methoxy}-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine'>JXS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj2 OCA], [https://pdbe.org/5qj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj2 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:[https://omim.org/entry/254600 254600]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.<ref>PMID:8142659</ref> <ref>PMID:7904599</ref> <ref>PMID:8621627</ref> <ref>PMID:9637725</ref> <ref>PMID:9354683</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PERM_HUMAN PERM_HUMAN] Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
		+
		+	==See Also==
		+	*[[Myeloperoxidase\|Myeloperoxidase]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Khan JA]]

OCA at 10:11, 18 March 2021

2021-03-18T10:11:34Z

←Older revision		Revision as of 10:11, 18 March 2021
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	<StructureSection load='5qj2' size='340' side='right'caption='[[5qj2]]' scene=''>		<StructureSection load='5qj2' size='340' side='right'caption='[[5qj2]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj2 OCA], [~~http~~://pdbe.org/5qj2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qj2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qj2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj2 ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj2 OCA], [https://pdbe.org/5qj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qj2 RCSB], [https://www.ebi.ac.uk/pdbsum/5qj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj2 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__

OCA at 11:10, 16 September 2020

2020-09-16T11:10:56Z

←Older revision		Revision as of 11:10, 16 September 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 5qj2 ~~is ON HOLD~~	+	====
-		+	<StructureSection load='5qj2' size='340' side='right'caption='[[5qj2]]' scene=''>
-	~~Authors~~: ~~Khan, J~~.A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1H-PYRAZOL-3-YL)BENZYL)OXY)-1H-~~[1,2,3]~~TRIAZOLO~~[4,~~5-B~~]~~PYRIDIN~~-~~5-AMINE~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5qj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qj2 OCA], [http://pdbe.org/5qj2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qj2 RCSB], [http://www.ebi.ac.uk/pdbsum/5qj2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qj2 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Khan, J.A~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "5qj2" [edit=sysop:move=sysop]

2018-10-03T06:08:11Z

Protected "5qj2" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:08, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 5qj2 is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1...

2018-10-03T06:08:09Z

New page: '''Unreleased structure''' The entry 5qj2 is ON HOLD Authors: Khan, J.A. Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1...

New page

'''Unreleased structure'''

The entry 5qj2 is ON HOLD

Authors: Khan, J.A.

Description: CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) OMPLEX WITH COMPOUND-20 AKA 7-((3-(1-METHYL-1H-PYRAZOL-3-YL)BENZYL)OXY)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE
[[Category: Unreleased Structures]]
[[Category: Khan, J.A]]