5qse - Revision history

OCA at 11:26, 21 February 2024

2024-02-21T11:26:30Z

←Older revision		Revision as of 11:26, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='5qse' size='340' side='right'caption='[[5qse]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='5qse' size='340' side='right'caption='[[5qse]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5qse]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5QSE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5qse]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QSE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O0V:(2S)-2-[(3-fluoropyridin-2-yl)(methyl)amino]propan-1-ol'>O0V</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.01Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5qse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qse OCA], [~~http~~://pdbe.org/5qse PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5qse RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5qse PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5qse ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O0V:(2S)-2-[(3-fluoropyridin-2-yl)(methyl)amino]propan-1-ol'>O0V</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qse OCA], [https://pdbe.org/5qse PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qse RCSB], [https://www.ebi.ac.uk/pdbsum/5qse PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qse ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.	+	[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]	+	[https://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
		+
		+	==See Also==
		+	*[[Brachyury\|Brachyury]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A]]~~	+	[[Category: Burgess-Brown NA]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards A]]
-	[[Category: Edwards, A]]	+	[[Category: Gavard AE]]
-	[[Category: Gavard~~, A E~~]]	+	[[Category: Gileadi O]]
-	[[Category: Gileadi, O]]	+	[[Category: Newman JA]]
-	[[Category: Newman~~, J A~~]]	+	[[Category: Sherestha L]]
-	[[Category: Sherestha, L]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Pandda]]~~	+
-	~~[[Category: Sgc - diamond i04-1 fragment screening]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Xchemexplorer~~]]	+

OCA at 05:46, 21 August 2019

2019-08-21T05:46:21Z

←Older revision		Revision as of 05:46, 21 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5qse is ~~ON HOLD~~	+	==PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in complex with Z2017168803==
-		+	<StructureSection load='5qse' size='340' side='right'caption='[[5qse]], [[Resolution\|resolution]] 2.01Å' scene=''>
-	~~Authors~~: ~~Newman~~, J.A., ~~Gavard~~, A.E., ~~Sherestha~~, L., Burgess-Brown, N.A~~., von~~ Delft, F~~., Arrowsmith, C.H.,~~ Edwards, A~~., Bountra, C.~~, Gileadi, O.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5qse]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QSE FirstGlance]. <br>
-	~~Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury G177D variant in complex with Z2017168803~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O0V:(2S)-2-[(3-fluoropyridin-2-yl)(methyl)amino]propan-1-ol'>O0V</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qse OCA], [http://pdbe.org/5qse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qse RCSB], [http://www.ebi.ac.uk/pdbsum/5qse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qse ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Thoracolumbosacral spina bifida cystica;Cervicothoracic spina bifida cystica;Lumbosacral spina bifida cystica;Cervicothoracic spina bifida aperta;Upper thoracic spina bifida aperta;Lumbosacral spina bifida aperta;Thoracolumbosacral spina bifida aperta;Cervical spina bifida cystica;Upper thoracic spina bifida cystica;Total spina bifida aperta;Chordoma;Total spina bifida cystica;Cervical spina bifida aperta;Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome. Disease susceptibility is associated with variations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Susceptibility to development of chordomas is due to a T gene duplication. The disease is caused by mutations affecting the gene represented in this entry.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TBXT_HUMAN TBXT_HUMAN]] Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site.[UniProtKB:P20293]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A]]
		+	[[Category: Gavard, A E]]
		+	[[Category: Gileadi, O]]
		+	[[Category: Newman, J A]]
	[[Category: Sherestha, L]]		[[Category: Sherestha, L]]
-	[[Category: ~~Arrowsmith, C.H~~]]	+	[[Category: Pandda]]
-	[[Category: ~~Gileadi, O]]~~	+	[[Category: Sgc - diamond i04-1 fragment screening]]
-	~~[[Category: Newman, J.A]]~~	+	[[Category: Transcription]]
-	~~[[Category: Edwards, A]]~~	+	[[Category: Xchemexplorer]]
-	~~[[Category: Burgess~~-~~Brown, N.A]]~~	+
-	~~[[Category: Gavard, A.E~~]]	+
-	[[Category: ~~Von Delft, F~~]]	+
-	[[Category: ~~Bountra, C~~]]	+

OCA: Protected "5qse" [edit=sysop:move=sysop]

2019-06-05T20:51:07Z

Protected "5qse" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:51, 5 June 2019

OCA: New page: '''Unreleased structure''' The entry 5qse is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

2019-06-05T20:51:06Z

New page: '''Unreleased structure''' The entry 5qse is ON HOLD Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., ...

New page

'''Unreleased structure'''

The entry 5qse is ON HOLD

Authors: Newman, J.A., Gavard, A.E., Sherestha, L., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.

Description: PanDDA analysis group deposition --Crystal Structure of human Brachyury G177D variant in complex with Z2017168803
[[Category: Unreleased Structures]]
[[Category: Sherestha, L]]
[[Category: Arrowsmith, C.H]]
[[Category: Gileadi, O]]
[[Category: Newman, J.A]]
[[Category: Edwards, A]]
[[Category: Burgess-Brown, N.A]]
[[Category: Gavard, A.E]]
[[Category: Von Delft, F]]
[[Category: Bountra, C]]