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5qt2 - Revision history
2026-04-11T05:41:27Z
Revision history for this page on the wiki
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http://52.214.119.220/wiki/index.php?title=5qt2&diff=4068739&oldid=prev
OCA at 11:27, 21 February 2024
2024-02-21T11:27:08Z
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 11:27, 21 February 2024</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='5qt2' size='340' side='right'caption='[[5qt2]], [[Resolution|resolution]] 1.59&Aring;' scene=''></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><StructureSection load='5qt2' size='340' side='right'caption='[[5qt2]], [[Resolution|resolution]] 1.59&Aring;' scene=''></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5qt2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QT2 OCA]. For a <b>guided tour on the structure components</b> use [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://<del style="color: red; font-weight: bold; text-decoration: none;">oca</del>.<del style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=5QT2 FirstGlance]. <br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>[[5qt2]] is a 1 chain structure <ins style="color: red; font-weight: bold; text-decoration: none;">with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]</ins>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QT2 OCA]. For a <b>guided tour on the structure components</b> use [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://<ins style="color: red; font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=5QT2 FirstGlance]. <br></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AW7:2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine'>AW7</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene<del style="color: red; font-weight: bold; text-decoration: none;">></td></tr></del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></td></tr><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;"><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span</del>></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat<ins style="color: red; font-weight: bold; text-decoration: none;">" id="ligandDat</ins>"><scene name='pdbligand=AW7:2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine'>AW7</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://<del style="color: red; font-weight: bold; text-decoration: none;">oca</del>.<del style="color: red; font-weight: bold; text-decoration: none;">weizmann.ac.il/oca-docs</del>/fgij/fg.htm?mol=5qt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qt2 OCA], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://pdbe.org/5qt2 PDBe], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.rcsb.org/pdb/explore.do?structureId=5qt2 RCSB], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.ebi.ac.uk/pdbsum/5qt2 PDBsum], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://prosat.h-its.org/prosat/prosatexe?pdbcode=5qt2 ProSAT]</span></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://<ins style="color: red; font-weight: bold; text-decoration: none;">proteopedia</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org</ins>/fgij/fg.htm?mol=5qt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qt2 OCA], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://pdbe.org/5qt2 PDBe], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.rcsb.org/pdb/explore.do?structureId=5qt2 RCSB], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.ebi.ac.uk/pdbsum/5qt2 PDBsum], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://prosat.h-its.org/prosat/prosatexe?pdbcode=5qt2 ProSAT]</span></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Function ==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[<del style="color: red; font-weight: bold; text-decoration: none;">[http</del>://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN<del style="color: red; font-weight: bold; text-decoration: none;">]</del>] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> <del style="color: red; font-weight: bold; text-decoration: none;"> </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== References ==</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><references/></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Histone-lysine N-methyltransferase</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Homo sapiens</ins>]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Arrowsmith<del style="color: red; font-weight: bold; text-decoration: none;">, C H</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Arrowsmith <ins style="color: red; font-weight: bold; text-decoration: none;">CH</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: BRANDAO-NETO<del style="color: red; font-weight: bold; text-decoration: none;">, </del>J]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: BRANDAO-NETO J]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Bountra<del style="color: red; font-weight: bold; text-decoration: none;">, </del>C]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Bountra C]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Collins<del style="color: red; font-weight: bold; text-decoration: none;">, P M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Collins <ins style="color: red; font-weight: bold; text-decoration: none;">PM</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: DOUANGAMATH<del style="color: red; font-weight: bold; text-decoration: none;">, </del>A<del style="color: red; font-weight: bold; text-decoration: none;">]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: DOUANGAMATH A]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Delft, F von</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Edwards <ins style="color: red; font-weight: bold; text-decoration: none;">AM</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Edwards<del style="color: red; font-weight: bold; text-decoration: none;">, A M</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Harding <ins style="color: red; font-weight: bold; text-decoration: none;">RJ</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Harding<del style="color: red; font-weight: bold; text-decoration: none;">, R J</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Krojer T]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Krojer<del style="color: red; font-weight: bold; text-decoration: none;">, </del>T]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Mader P]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Mader<del style="color: red; font-weight: bold; text-decoration: none;">, </del>P]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Santhakumar V]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Santhakumar<del style="color: red; font-weight: bold; text-decoration: none;">, </del>V]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Schapira M]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Schapira<del style="color: red; font-weight: bold; text-decoration: none;">, </del>M]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Tempel W]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Tempel<del style="color: red; font-weight: bold; text-decoration: none;">, </del>W]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Von Delft F</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Pandda]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Sgc - diamond i04-1 fragment screening]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Transferase]]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">[[Category: Xchemexplorer</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=5qt2&diff=3083864&oldid=prev
OCA at 05:48, 21 August 2019
2019-08-21T05:48:03Z
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 05:48, 21 August 2019</td>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>5qt2 <del style="color: red; font-weight: bold; text-decoration: none;">is ON HOLD </del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">==PanDDA analysis group deposition -- Partial occupancy interpretation of PanDDA event map: SETDB1 in complex with FMOPL000074a==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>5qt2<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[5qt2]], [[Resolution|resolution]] 1.59&Aring;' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Harding, R</del>.<del style="color: red; font-weight: bold; text-decoration: none;">J</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Tempel</del>, <del style="color: red; font-weight: bold; text-decoration: none;">W.</del>, <del style="color: red; font-weight: bold; text-decoration: none;">DOUANGAMATH</del>, <del style="color: red; font-weight: bold; text-decoration: none;">A.</del>, <del style="color: red; font-weight: bold; text-decoration: none;">BRANDAO</del>-<del style="color: red; font-weight: bold; text-decoration: none;">NETO</del>, <del style="color: red; font-weight: bold; text-decoration: none;">J</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Collins, P</del>.<del style="color: red; font-weight: bold; text-decoration: none;">M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Krojer, T</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Mader, P</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Schapira, M</del>., <del style="color: red; font-weight: bold; text-decoration: none;">von Delft, F</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Bountra, C</del>., <del style="color: red; font-weight: bold; text-decoration: none;">Edwards, A</del>.<del style="color: red; font-weight: bold; text-decoration: none;">M</del>., Arrowsmith, C<del style="color: red; font-weight: bold; text-decoration: none;">.</del>H<del style="color: red; font-weight: bold; text-decoration: none;">.</del>, <del style="color: red; font-weight: bold; text-decoration: none;">Santhakumar</del>, <del style="color: red; font-weight: bold; text-decoration: none;">V.</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>[[5qt2]] is a 1 chain structure. Full crystallographic information is available from [http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocashort?id=5QT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QT2 FirstGlance]. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description</del>: <del style="color: red; font-weight: bold; text-decoration: none;">PanDDA analysis group deposition --Partial occupancy interpretation of PanDDA event map</del>: <del style="color: red; font-weight: bold; text-decoration: none;">SETDB1 in complex with FMOPL000074a</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AW7:2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine'>AW7</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=EDO:1</ins>,<ins style="color: red; font-weight: bold; text-decoration: none;">2-ETHANEDIOL'>EDO</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></ins>, <ins style="color: red; font-weight: bold; text-decoration: none;"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased Structures</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone</ins>-<ins style="color: red; font-weight: bold; text-decoration: none;">lysine_N-methyltransferase Histone-lysine N-methyltransferase]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">with EC number [http://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qt2 FirstGlance]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac.il/oca-bin/ocaids?id=5qt2 OCA]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://pdbe</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">org/5qt2 PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">rcsb.org/pdb/explore.do?structureId=5qt2 RCSB]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://www</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ebi.ac.uk/pdbsum/5qt2 PDBsum]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://prosat</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">h-its.org/prosat/prosatexe?pdbcode=5qt2 ProSAT]</span></td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Function ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[http://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN]] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">CBX3 and/or CBX5) proteins to methylated histones</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">Mainly functions in euchromatin regions</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">thereby playing a central role in the silencing of euchromatic genes</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">H3 'Lys-9' trimethylation is coordinated with DNA methylation</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref> </ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== References ==</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><references/></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Histone-lysine N-methyltransferase]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Large Structures]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: </ins>Arrowsmith, C H<ins style="color: red; font-weight: bold; text-decoration: none;">]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: BRANDAO-NETO</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">J]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Bountra</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">C]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Collins, P M]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category</ins>: <ins style="color: red; font-weight: bold; text-decoration: none;">DOUANGAMATH, A]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category</ins>: <ins style="color: red; font-weight: bold; text-decoration: none;">Delft, F von]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Edwards, A M]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Harding, R J]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Krojer, T]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Mader, P]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Santhakumar, V</ins>]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Schapira, M]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Schapira, M]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Edwards, A.M]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Arrowsmith, C.H]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Brandao-Neto, J]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Santhakumar, V]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Collins, P.M]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Douangamath, A]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Mader, P]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Krojer, T]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Harding, R.J]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Von Delft, F]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Bountra, C]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Tempel, W]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Tempel, W]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Pandda]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Sgc - diamond i04-1 fragment screening]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Transferase]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Xchemexplorer]]</div></td></tr>
</table>
OCA
http://52.214.119.220/wiki/index.php?title=5qt2&diff=3061725&oldid=prev
OCA: Protected "5qt2" [edit=sysop:move=sysop]
2019-07-03T04:00:16Z
<p>Protected "<a href="/wiki/index.php/5qt2" title="5qt2">5qt2</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">←Older revision</td>
<td colspan='2' style="background-color: white; color:black;">Revision as of 04:00, 3 July 2019</td>
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OCA
http://52.214.119.220/wiki/index.php?title=5qt2&diff=3061724&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 5qt2 is ON HOLD Authors: Harding, R.J., Tempel, W., DOUANGAMATH, A., BRANDAO-NETO, J., Collins, P.M., Krojer, T., Mader, P., Schapira, M., von Delft...
2019-07-03T04:00:14Z
<p>New page: '''Unreleased structure''' The entry 5qt2 is ON HOLD Authors: Harding, R.J., Tempel, W., DOUANGAMATH, A., BRANDAO-NETO, J., Collins, P.M., Krojer, T., Mader, P., Schapira, M., von Delft...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
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The entry 5qt2 is ON HOLD <br />
<br />
Authors: Harding, R.J., Tempel, W., DOUANGAMATH, A., BRANDAO-NETO, J., Collins, P.M., Krojer, T., Mader, P., Schapira, M., von Delft, F., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Santhakumar, V.<br />
<br />
Description: PanDDA analysis group deposition --Partial occupancy interpretation of PanDDA event map: SETDB1 in complex with FMOPL000074a<br />
[[Category: Unreleased Structures]]<br />
[[Category: Schapira, M]]<br />
[[Category: Edwards, A.M]]<br />
[[Category: Arrowsmith, C.H]]<br />
[[Category: Brandao-Neto, J]]<br />
[[Category: Santhakumar, V]]<br />
[[Category: Collins, P.M]]<br />
[[Category: Douangamath, A]]<br />
[[Category: Mader, P]]<br />
[[Category: Krojer, T]]<br />
[[Category: Harding, R.J]]<br />
[[Category: Von Delft, F]]<br />
[[Category: Bountra, C]]<br />
[[Category: Tempel, W]]</div>
OCA