5rhn - Revision history

OCA at 14:06, 6 March 2024

2024-03-06T14:06:03Z

←Older revision		Revision as of 14:06, 6 March 2024
Line 1:		Line 1:
		+
	==HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP==		==HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP==
-	<StructureSection load='5rhn' size='340' side='right' caption='[[5rhn]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='5rhn' size='340' side='right'caption='[[5rhn]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~European_rabbit European rabbit~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5RHN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5RHN FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=8BR:8~~-~~BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=5~~&id=9986 European rabbit])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [~~http~~://pdbe.org/5rhn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [https://pdbe.org/5rhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [https://www.ebi.ac.uk/pdbsum/5rhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5rhn ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HINT1_RABIT HINT1_RABIT]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.	+	[https://www.uniprot.org/uniprot/HINT1_RABIT HINT1_RABIT] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/5rhn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/5rhn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5rhn ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5rhn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Crystal structures of HINT-nucleotide complexes demonstrate that the most conserved residues in the superfamily mediate nucleotide binding and that the HIT motif forms part of the phosphate binding loop. Galactose-1-phosphate uridylyltransferase, whose deficiency causes galactosemia, contains tandem HINT domains with the same fold and mode of nucleotide binding as HINT despite having no overall sequence similarity. Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT-nucleotide structures.
-
-	Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.,Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465<ref>PMID:9164465</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5rhn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Histidine triad nucleotide-binding protein\|Histidine triad nucleotide-binding protein]]	+	*[[Histidine triad nucleotide-binding protein 3D structures\|Histidine triad nucleotide-binding protein 3D structures]]
-	~~== References ==~~	+
-	~~<references/>~~	+
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~European rabbit~~]]	+	[[Category: Large Structures]]
-	[[Category: Brenner, C]]	+	[[Category: Oryctolagus cuniculus]]
-	[[Category: Garrison, P]]	+	[[Category: Brenner C]]
-	[[Category: Gilmour, J]]	+	[[Category: Garrison P]]
-	[[Category: Lowenstein~~, J M~~]]	+	[[Category: Gilmour J]]
-	[[Category: Peisach, D]]	+	[[Category: Lowenstein JM]]
-	[[Category: Petsko~~, G A~~]]	+	[[Category: Peisach D]]
-	[[Category: Ringe, D]]	+	[[Category: Petsko GA]]
-	~~[[Category: Nucleotide-binding protein~~]]	+	[[Category: Ringe D]]

OCA at 12:36, 7 February 2016

2016-02-07T12:36:26Z

←Older revision		Revision as of 12:36, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='5rhn' size='340' side='right' caption='[[5rhn]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='5rhn' size='340' side='right' caption='[[5rhn]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Oryctolagus_cuniculus Oryctolagus cuniculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5RHN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5RHN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 ~~Oryctolagus cuniculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://pdbe.org/5rhn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=5rhn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 5rhn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Oryctolagus cuniculus~~]]	+	[[Category: European rabbit]]
	[[Category: Brenner, C]]		[[Category: Brenner, C]]
	[[Category: Garrison, P]]		[[Category: Garrison, P]]

OCA at 15:09, 24 December 2014

2014-12-24T15:09:24Z

←Older revision		Revision as of 15:09, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5RHN FirstGlance]. <br>		<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5RHN FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HINT1_RABIT HINT1_RABIT]] Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+
		+	==See Also==
		+	*[[Histidine triad nucleotide-binding protein\|Histidine triad nucleotide-binding protein]]
	== References ==		== References ==
	<references/>		<references/>
Line 30:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Brenner, C.]]	+	[[Category: Brenner, C]]
-	[[Category: Garrison, P.]]	+	[[Category: Garrison, P]]
-	[[Category: Gilmour, J.]]	+	[[Category: Gilmour, J]]
-	[[Category: Lowenstein, J M.]]	+	[[Category: Lowenstein, J M]]
-	[[Category: Peisach, D.]]	+	[[Category: Peisach, D]]
-	[[Category: Petsko, G A.]]	+	[[Category: Petsko, G A]]
-	[[Category: Ringe, D.]]	+	[[Category: Ringe, D]]
	[[Category: Nucleotide-binding protein]]		[[Category: Nucleotide-binding protein]]

OCA: Protected "5rhn" [edit=sysop:move=sysop]

2014-06-05T07:33:04Z

Protected "5rhn" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:33, 5 June 2014

OCA at 07:33, 5 June 2014

2014-06-05T07:33:02Z

←Older revision		Revision as of 07:33, 5 June 2014
Line 1:		Line 1:
-	~~{{Seed}}~~	+	==HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP==
-	[[~~Image:~~5rhn.~~png~~\|~~left~~\|200px]]	+	<StructureSection load='5rhn' size='340' side='right' caption='[[5rhn]], [[Resolution\|resolution]] 2.31Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5rhn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5RHN FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5-MONOPHOSPHATE'>8BR</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/5rhn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Histidine triad nucleotide-binding protein (HINT), a dimeric purine nucleotide-binding protein from rabbit heart, is a member of the HIT (histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded at the chromosome 3 fragile site) homologues. Crystal structures of HINT-nucleotide complexes demonstrate that the most conserved residues in the superfamily mediate nucleotide binding and that the HIT motif forms part of the phosphate binding loop. Galactose-1-phosphate uridylyltransferase, whose deficiency causes galactosemia, contains tandem HINT domains with the same fold and mode of nucleotide binding as HINT despite having no overall sequence similarity. Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT-nucleotide structures.

-	<!--	+	Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins.,Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465<ref>PMID:9164465</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_5rhn"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_5rhn\| PDB=5rhn \| SCENE= }}~~	+

-	~~===HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_9164465}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 9164465 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_9164465}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~5RHN is a 1 chain structure of sequence from [http:~~/~~/en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:9164465<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Brenner, C.]]		[[Category: Brenner, C.]]
Line 33:		Line 38:
	[[Category: Ringe, D.]]		[[Category: Ringe, D.]]
	[[Category: Nucleotide-binding protein]]		[[Category: Nucleotide-binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:51:05 2009''

OCA at 11:51, 16 February 2009

2009-02-16T11:51:06Z

←Older revision		Revision as of 11:51, 16 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
-	5RHN is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA].	+	5RHN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5RHN OCA].

	==Reference==		==Reference==
-	Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins., Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM, Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/9164465 9164465]~~	+	<ref group="xtra">PMID:9164465</ref><references group="xtra"/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
-	[[Category: Single protein]]
	[[Category: Brenner, C.]]		[[Category: Brenner, C.]]
	[[Category: Garrison, P.]]		[[Category: Garrison, P.]]
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	[[Category: Nucleotide-binding protein]]		[[Category: Nucleotide-binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Jul 3 14~~:10:~~20 2008~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:51:05 2009''

OCA at 11:10, 3 July 2008

2008-07-03T11:10:21Z

←Older revision		Revision as of 11:10, 3 July 2008
Line 1:		Line 1:
-	[[Image:5rhn.~~gif~~\|left\|200px]]	+	{{Seed}}
		+	[[Image:5rhn.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_5rhn\| PDB=5rhn \| SCENE= }}		{{STRUCTURE_5rhn\| PDB=5rhn \| SCENE= }}

-	~~'''~~HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP~~'''~~	+	===HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP===


-	~~==Overview==~~	+	<!--
-	~~Histidine triad nucleotide~~-~~binding protein (HINT), a dimeric purine nucleotide~~-~~binding protein from rabbit heart~~, ~~is a member of~~ the ~~HIT~~ (~~histidine triad) superfamily which includes HINT homologues and FHIT (HIT protein encoded~~ at ~~the chromosome 3 fragile site) homologues~~. Crystal structures of HINT-nucleotide complexes demonstrate that the most conserved residues in the superfamily mediate nucleotide binding and that the HIT motif forms part of the phosphate binding loop. ~~Galactose-1-phosphate uridylyltransferase~~, ~~whose deficiency causes galactosemia, contains tandem HINT domains with~~ the ~~same fold and mode of nucleotide binding as HINT despite having no overall sequence similarity~~. ~~Features of FHIT, a diadenosine polyphosphate hydrolase and candidate tumour suppressor, are predicted from HINT~~-~~nucleotide structures.~~	+	The line below this paragraph, {{ABSTRACT_PUBMED_9164465}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 9164465 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_9164465}}

	==About this Structure==		==About this Structure==
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	[[Category: Ringe, D.]]		[[Category: Ringe, D.]]
	[[Category: Nucleotide-binding protein]]		[[Category: Nucleotide-binding protein]]
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May~~ ~~4 22~~:37:28 2008''	+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:10:20 2008''

OCA at 19:37, 4 May 2008

2008-05-04T19:37:29Z

←Older revision		Revision as of 19:37, 4 May 2008
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	[[Image:5rhn.gif\|left\|200px]]		[[Image:5rhn.gif\|left\|200px]]

-	{{Structure	+	<!--
-	\|PDB~~= 5rhn \|SIZE=350\|CAPTION= <~~scene ~~name='initialview01'>5rhn</scene>~~, ~~resolution 2.31Å~~	+	The line below this paragraph, containing "STRUCTURE_5rhn", creates the "Structure Box" on the page.
-	~~\|SITE= <scene name='pdbsite=HIT:The+HIS+Triad+Forms+Part+Of+Alpha+Phosphate-Binding+Loop+~~.~~..'>HIT</scene>~~	+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	~~\|LIGAND= <scene name='pdbligand=8BR:8~~-~~BROMO~~-~~ADENOSINE-5'-MONOPHOSPHATE'>8BR</scene~~>	+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	\|~~ACTIVITY~~=	+	or leave the SCENE parameter empty for the default display.
-	\|~~GENE~~= ~~HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])~~	+	-->
-	~~\|DOMAIN=~~	+	{{STRUCTURE_5rhn\| PDB=5rhn \| SCENE= }}
-	~~\|RELATEDENTRY=~~	+
-	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB]</span>	+
-	}}	+

	'''HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP'''		'''HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH 8-BR-AMP'''
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	[[Category: Petsko, G A.]]		[[Category: Petsko, G A.]]
	[[Category: Ringe, D.]]		[[Category: Ringe, D.]]
-	[[Category: ~~nucleotide~~-binding protein]]	+	[[Category: Nucleotide-binding protein]]
-		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:37:28 2008''
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Mar 31 05~~:42:11 2008''	+

OCA at 02:42, 31 March 2008

2008-03-31T02:42:13Z

←Older revision		Revision as of 02:42, 31 March 2008
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	\|ACTIVITY=		\|ACTIVITY=
	\|GENE= HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])		\|GENE= HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])
		+	\|DOMAIN=
		+	\|RELATEDENTRY=
		+	\|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5rhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5rhn OCA], [http://www.ebi.ac.uk/pdbsum/5rhn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=5rhn RCSB]</span>
	}}		}}

Line 29:		Line 32:
	[[Category: Petsko, G A.]]		[[Category: Petsko, G A.]]
	[[Category: Ringe, D.]]		[[Category: Ringe, D.]]
-	[[Category: 8BR]]
	[[Category: nucleotide-binding protein]]		[[Category: nucleotide-binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun~~ Mar ~~23 16:~~05:41 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:42:11 2008''

OCA at 14:05, 23 March 2008

2008-03-23T14:05:41Z

←Older revision		Revision as of 14:05, 23 March 2008
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	\|PDB= 5rhn \|SIZE=350\|CAPTION= <scene name='initialview01'>5rhn</scene>, resolution 2.31Å		\|PDB= 5rhn \|SIZE=350\|CAPTION= <scene name='initialview01'>5rhn</scene>, resolution 2.31Å
	\|SITE= <scene name='pdbsite=HIT:The+HIS+Triad+Forms+Part+Of+Alpha+Phosphate-Binding+Loop+...'>HIT</scene>		\|SITE= <scene name='pdbsite=HIT:The+HIS+Triad+Forms+Part+Of+Alpha+Phosphate-Binding+Loop+...'>HIT</scene>
-	\|LIGAND= <scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5'-MONOPHOSPHATE'>8BR</scene>	+	\|LIGAND= <scene name='pdbligand=8BR:8-BROMO-ADENOSINE-5'-MONOPHOSPHATE'>8BR</scene>
	\|ACTIVITY=		\|ACTIVITY=
	\|GENE= HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])		\|GENE= HINT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])
Line 32:		Line 32:
	[[Category: nucleotide-binding protein]]		[[Category: nucleotide-binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 19~~:12:49 2008''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 16:05:41 2008''