5tgy - Revision history

OCA at 10:24, 14 June 2023

2023-06-14T10:24:54Z

←Older revision		Revision as of 10:24, 14 June 2023
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	==NMR structure of holo-PS1==		==NMR structure of holo-PS1==
-	<StructureSection load='5tgy' size='340' side='right'caption='[[5tgy~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='5tgy' size='340' side='right'caption='[[5tgy]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TGY FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BU:[5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc'>7BU</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7BU:[5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc'>7BU</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tgw\|5tgw]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgy OCA], [https://pdbe.org/5tgy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tgy RCSB], [https://www.ebi.ac.uk/pdbsum/5tgy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgy ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgy OCA], [~~http~~://pdbe.org/5tgy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tgy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tgy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgy ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Polizzi~~, N F~~]]	+	[[Category: Polizzi NF]]
-	[[Category: Wu, Y]]	+	[[Category: Wu Y]]
-	~~[[Category: 4-helix bundle]]~~	+
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Holoprotein]]~~	+
-	~~[[Category: Unknown function~~]]	+

OCA at 07:52, 27 November 2019

2019-11-27T07:52:58Z

←Older revision		Revision as of 07:52, 27 November 2019
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	==NMR structure of holo-PS1==		==NMR structure of holo-PS1==
-	<StructureSection load='5tgy' size='340' side='right' caption='[[5tgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>	+	<StructureSection load='5tgy' size='340' side='right'caption='[[5tgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGY FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGY FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
		+	[[Category: Large Structures]]
	[[Category: Polizzi, N F]]		[[Category: Polizzi, N F]]
	[[Category: Wu, Y]]		[[Category: Wu, Y]]

OCA at 07:46, 6 December 2017

2017-12-06T07:46:48Z

←Older revision		Revision as of 07:46, 6 December 2017
Line 3:		Line 3:
	<StructureSection load='5tgy' size='340' side='right' caption='[[5tgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='5tgy' size='340' side='right' caption='[[5tgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGY FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BU:[5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc'>7BU</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BU:[5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc'>7BU</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tgw\|5tgw]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tgw\|5tgw]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgy OCA], [http://pdbe.org/5tgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tgy RCSB], [http://www.ebi.ac.uk/pdbsum/5tgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgy OCA], [http://pdbe.org/5tgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tgy RCSB], [http://www.ebi.ac.uk/pdbsum/5tgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein catalysis requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecule-binding protein entirely from first principles with a precisely predetermined structure has not been demonstrated. Here we report the design of a novel protein, PS1, that binds a highly electron-deficient non-natural porphyrin at temperatures up to 100 degrees C. The high-resolution structure of holo-PS1 is in sub-A agreement with the design. The structure of apo-PS1 retains the remote core packing of the holoprotein, with a flexible binding region that is predisposed to ligand binding with the desired geometry. Our results illustrate the unification of core packing and binding-site definition as a central principle of ligand-binding protein design.
		+
		+	De novo design of a hyperstable non-natural protein-ligand complex with sub-A accuracy.,Polizzi NF, Wu Y, Lemmin T, Maxwell AM, Zhang SQ, Rawson J, Beratan DN, Therien MJ, DeGrado WF Nat Chem. 2017 Dec;9(12):1157-1164. doi: 10.1038/nchem.2846. Epub 2017 Aug 21. PMID:29168496<ref>PMID:29168496</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5tgy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Polizzi, N F]]		[[Category: Polizzi, N F]]
	[[Category: Wu, Y]]		[[Category: Wu, Y]]

OCA at 10:53, 7 October 2017

2017-10-07T10:53:04Z

←Older revision		Revision as of 10:53, 7 October 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tgy is ~~ON HOLD until Paper Publication~~	+	==NMR structure of holo-PS1==
-		+	<StructureSection load='5tgy' size='340' side='right' caption='[[5tgy]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5tgy]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TGY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TGY FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BU:[5,10,15,20-tetrakis(trifluoromethyl)porphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]zinc'>7BU</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tgw\|5tgw]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tgy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tgy OCA], [http://pdbe.org/5tgy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tgy RCSB], [http://www.ebi.ac.uk/pdbsum/5tgy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tgy ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Polizzi, N F]]
		+	[[Category: Wu, Y]]
		+	[[Category: 4-helix bundle]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Holoprotein]]
		+	[[Category: Unknown function]]

OCA at 17:30, 9 December 2016

2016-12-09T17:30:11Z

←Older revision		Revision as of 17:30, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tgy is ON HOLD	+	The entry 5tgy is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tgy" [edit=sysop:move=sysop]

2016-10-05T20:04:26Z

Protected "5tgy" [edit=sysop:move=sysop]

←Older revision

Revision as of 20:04, 5 October 2016

OCA: New page: '''Unreleased structure''' The entry 5tgy is ON HOLD Authors: Description: Category: Unreleased Structures

2016-10-05T20:04:25Z

New page: '''Unreleased structure''' The entry 5tgy is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tgy is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]