5tr1 - Revision history

OCA at 15:42, 6 March 2024

2024-03-06T15:42:44Z

←Older revision		Revision as of 15:42, 6 March 2024
Line 3:		Line 3:
	<SX load='5tr1' size='340' side='right' viewer='molstar' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>		<SX load='5tr1' size='340' side='right' viewer='molstar' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bovin Bovin~~] and [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.95Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5tqq\|5tqq]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">LOC101909378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [https://pdbe.org/5tr1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [https://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [~~http~~://pdbe.org/5tr1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>	+
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/E1B792_BOVIN E1B792_BOVIN]
-	CLC proteins transport chloride (Cl-) ions across cellular membranes to regulate muscle excitability, electrolyte movement across epithelia, and acidification of intracellular organelles. Some CLC proteins are channels that conduct Cl- ions passively, whereas others are secondary active transporters that exchange two Cl- ions for one H+. The structural basis underlying these distinctive transport mechanisms is puzzling because CLC channels and transporters are expected to share the same architecture on the basis of sequence homology. Here we determined the structure of a bovine CLC channel (CLC-K) using cryo-electron microscopy. A conserved loop in the Cl- transport pathway shows a structure markedly different from that of CLC transporters. Consequently, the cytosolic constriction for Cl- passage is widened in CLC-K such that the kinetic barrier previously postulated for Cl-/H+ transporter function would be reduced. Thus, reduction of a kinetic barrier in CLC channels enables fast flow of Cl- down its electrochemical gradient.	+
-		+
-	~~Structure of a CLC chloride ion channel by cryo-electron microscopy.,Park E, Campbell EB, MacKinnon R Nature. 2016 Dec 21. doi~~: ~~10.1038~~/~~nature20812. PMID:28002411<ref>PMID:28002411<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 5tr1" style="background-color:#fffaf0;"><~~/~~div>~~	+

	==See Also==		==See Also==
	*[[Ion channels 3D structures\|Ion channels 3D structures]]		*[[Ion channels 3D structures\|Ion channels 3D structures]]
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Bovin~~]]	+	[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: MacKinnon, R]]	+	[[Category: MacKinnon R]]
-	[[Category: Park, E]]	+	[[Category: Park E]]
-	~~[[Category: Chloride channel]]~~	+
-	~~[[Category: Clc]]~~	+
-	~~[[Category: Kidney]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 21:46, 10 April 2020

2020-04-10T21:46:41Z

←Older revision		Revision as of 21:46, 10 April 2020
Line 3:		Line 3:
	<SX load='5tr1' size='340' side='right' viewer='molstar' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>		<SX load='5tr1' size='340' side='right' viewer='molstar' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tqq\|5tqq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tqq\|5tqq]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOC101909378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOC101909378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [http://pdbe.org/5tr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [http://pdbe.org/5tr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 19:38, 6 March 2020

2020-03-06T19:38:26Z

←Older revision		Revision as of 19:38, 6 March 2020
Line 1:		Line 1:

	==Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation==		==Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation==
-	<~~StructureSection~~ load='5tr1' size='340' side='right'caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>	+	<SX load='5tr1' size='340' side='right' viewer='molstar' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
Line 25:		Line 25:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bovin]]		[[Category: Bovin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 07:22, 6 November 2019

2019-11-06T07:22:43Z

←Older revision		Revision as of 07:22, 6 November 2019
Line 1:		Line 1:

	==Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation==		==Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation==
-	<StructureSection load='5tr1' size='340' side='right' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>	+	<StructureSection load='5tr1' size='340' side='right'caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]	+	*[[Ion channels 3D structures\|Ion channels 3D structures]]
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: MacKinnon, R]]		[[Category: MacKinnon, R]]

OCA at 09:07, 18 July 2018

2018-07-18T09:07:56Z

←Older revision		Revision as of 09:07, 18 July 2018
Line 3:		Line 3:
	<StructureSection load='5tr1' size='340' side='right' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>		<StructureSection load='5tr1' size='340' side='right' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tqq\|5tqq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tqq\|5tqq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LOC101909378 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [http://pdbe.org/5tr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [http://pdbe.org/5tr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>
	</table>		</table>
Line 19:		Line 20:

	==See Also==		==See Also==
-	*[[3D structures ~~of monoclonal antibody~~\|3D structures ~~of monoclonal antibody~~]]	+	*[[Ion channels\|Ion channels]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bovin]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: MacKinnon, R]]		[[Category: MacKinnon, R]]

OCA at 14:26, 6 November 2017

2017-11-06T14:26:35Z

←Older revision		Revision as of 14:26, 6 November 2017
Line 19:		Line 19:

	==See Also==		==See Also==
-	*[[Ion channels\|Ion channels]]
	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]		*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==

OCA at 10:05, 27 September 2017

2017-09-27T10:05:09Z

←Older revision		Revision as of 10:05, 27 September 2017
Line 19:		Line 19:

	==See Also==		==See Also==
		+	*[[Ion channels\|Ion channels]]
	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]		*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==

OCA at 07:11, 9 March 2017

2017-03-09T07:11:33Z

←Older revision		Revision as of 07:11, 9 March 2017
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5tr1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5tr1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 16:39, 18 January 2017

2017-01-18T16:39:43Z

←Older revision		Revision as of 16:39, 18 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tr1 is ~~ON HOLD until Paper~~ Publication	+	==Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation==
		+	<StructureSection load='5tr1' size='340' side='right' caption='[[5tr1]], [[Resolution\|resolution]] 3.95Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5tr1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TR1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tqq\|5tqq]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tr1 OCA], [http://pdbe.org/5tr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tr1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CLC proteins transport chloride (Cl-) ions across cellular membranes to regulate muscle excitability, electrolyte movement across epithelia, and acidification of intracellular organelles. Some CLC proteins are channels that conduct Cl- ions passively, whereas others are secondary active transporters that exchange two Cl- ions for one H+. The structural basis underlying these distinctive transport mechanisms is puzzling because CLC channels and transporters are expected to share the same architecture on the basis of sequence homology. Here we determined the structure of a bovine CLC channel (CLC-K) using cryo-electron microscopy. A conserved loop in the Cl- transport pathway shows a structure markedly different from that of CLC transporters. Consequently, the cytosolic constriction for Cl- passage is widened in CLC-K such that the kinetic barrier previously postulated for Cl-/H+ transporter function would be reduced. Thus, reduction of a kinetic barrier in CLC channels enables fast flow of Cl- down its electrochemical gradient.

-	~~Authors~~:	+	Structure of a CLC chloride ion channel by cryo-electron microscopy.,Park E, Campbell EB, MacKinnon R Nature. 2016 Dec 21. doi: 10.1038/nature20812. PMID:28002411<ref>PMID:28002411</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5tr1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: MacKinnon, R]]
		+	[[Category: Park, E]]
		+	[[Category: Chloride channel]]
		+	[[Category: Clc]]
		+	[[Category: Kidney]]
		+	[[Category: Membrane]]
		+	[[Category: Transport protein]]

OCA at 14:43, 2 January 2017

2017-01-02T14:43:15Z

←Older revision		Revision as of 14:43, 2 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tr1 is ON HOLD	+	The entry 5tr1 is ON HOLD until Paper Publication

	Authors:		Authors: