5tvt - Revision history

OCA at 14:23, 6 March 2024

2024-03-06T14:23:38Z

←Older revision		Revision as of 14:23, 6 March 2024
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	<StructureSection load='5tvt' size='340' side='right'caption='[[5tvt]], [[Resolution\|resolution]] 2.28Å' scene=''>		<StructureSection load='5tvt' size='340' side='right'caption='[[5tvt]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tvt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5TVT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tvt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TVT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LV:9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one'>7LV</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.28Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5twl\|5twl]], [[5twy\|5twy]], [[5twu\|5twu]], [[5twz\|5twz]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LV:9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one'>7LV</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvt OCA], [~~http~~://pdbe.org/5tvt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5tvt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5tvt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvt OCA], [https://pdbe.org/5tvt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tvt RCSB], [https://www.ebi.ac.uk/pdbsum/5tvt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN]] Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation.	+	[https://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN] Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:11802789</ref> <ref>PMID:12400006</ref> <ref>PMID:14699119</ref> <ref>PMID:15908796</ref> <ref>PMID:16216881</ref> <ref>PMID:17280616</ref>	+	[https://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:11802789</ref> <ref>PMID:12400006</ref> <ref>PMID:14699119</ref> <ref>PMID:15908796</ref> <ref>PMID:16216881</ref> <ref>PMID:17280616</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dhe-Paganon, S]]	+	[[Category: Dhe-Paganon S]]
-	[[Category: Gray~~, N S~~]]	+	[[Category: Gray NS]]
-	[[Category: Huang, H]]	+	[[Category: Huang H]]
-	[[Category: Seo, H Y]]	+	[[Category: Seo H-Y]]
-	~~[[Category: Kinase inhibitor]]~~	+
-	~~[[Category: Transferase-transferase inhibitor complex~~]]	+

OCA at 12:20, 23 September 2020

2020-09-23T12:20:59Z

←Older revision		Revision as of 12:20, 23 September 2020
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	==Structure of Maternal Embryonic Leucine Zipper Kinase==		==Structure of Maternal Embryonic Leucine Zipper Kinase==
-	<StructureSection load='5tvt' size='340' side='right' caption='[[5tvt]], [[Resolution\|resolution]] 2.28Å' scene=''>	+	<StructureSection load='5tvt' size='340' side='right'caption='[[5tvt]], [[Resolution\|resolution]] 2.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5tvt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5TVT FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5tvt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TVT FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LV:9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one'>7LV</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LV:9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one'>7LV</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5twl\|5twl]], [[5twy\|5twy]], [[5twu\|5twu]], [[5twz\|5twz]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5twl\|5twl]], [[5twy\|5twy]], [[5twu\|5twu]], [[5twz\|5twz]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvt OCA], [http://pdbe.org/5tvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tvt RCSB], [http://www.ebi.ac.uk/pdbsum/5tvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvt ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvt OCA], [http://pdbe.org/5tvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tvt RCSB], [http://www.ebi.ac.uk/pdbsum/5tvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Dhe-Paganon, S]]		[[Category: Dhe-Paganon, S]]
	[[Category: Gray, N S]]		[[Category: Gray, N S]]

OCA at 07:30, 15 November 2017

2017-11-15T07:30:56Z

←Older revision		Revision as of 07:30, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5tvt is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Structure of Maternal Embryonic Leucine Zipper Kinase==
-		+	<StructureSection load='5tvt' size='340' side='right' caption='[[5tvt]], [[Resolution\|resolution]] 2.28Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5tvt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TVT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TVT FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7LV:9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one'>7LV</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5twl\|5twl]], [[5twy\|5twy]], [[5twu\|5twu]], [[5twz\|5twz]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tvt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tvt OCA], [http://pdbe.org/5tvt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tvt RCSB], [http://www.ebi.ac.uk/pdbsum/5tvt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tvt ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN]] Note=Defects in MELK are associated with some cancers, such as brain or breast cancers. Expression is dramatically increased in aggressive undifferentiated tumors, correlating with poor patient outcome in breast and brain cancers, suggesting a role in tumor-initiating cells and proliferation via its function in cell proliferation regulation.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MELK_HUMAN MELK_HUMAN]] Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.<ref>PMID:11802789</ref> <ref>PMID:12400006</ref> <ref>PMID:14699119</ref> <ref>PMID:15908796</ref> <ref>PMID:16216881</ref> <ref>PMID:17280616</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dhe-Paganon, S]]
		+	[[Category: Gray, N S]]
		+	[[Category: Huang, H]]
		+	[[Category: Seo, H Y]]
		+	[[Category: Kinase inhibitor]]
		+	[[Category: Transferase-transferase inhibitor complex]]

OCA at 17:23, 15 December 2016

2016-12-15T17:23:05Z

←Older revision		Revision as of 17:23, 15 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5tvt is ON HOLD	+	The entry 5tvt is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5tvt" [edit=sysop:move=sysop]

2016-12-09T17:57:21Z

Protected "5tvt" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5tvt is ON HOLD Authors: Description: Category: Unreleased Structures

2016-12-09T17:57:20Z

New page: '''Unreleased structure''' The entry 5tvt is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5tvt is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]