5u0r - Revision history

OCA at 13:17, 4 October 2023

2023-10-04T13:17:52Z

←Older revision		Revision as of 13:17, 4 October 2023
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	<StructureSection load='5u0r' size='340' side='right'caption='[[5u0r]], [[Resolution\|resolution]] 3.29Å' scene=''>		<StructureSection load='5u0r' size='340' side='right'caption='[[5u0r]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u0r]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0R OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5U0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U0R FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.295Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5tpl\|5tpl]], [[5tpp\|5tpp]], [[5tqa\|5tqa]], [[5trp\|5trp]], [[5u0u\|5u0u]], [[5u15\|5u15]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0r OCA], [~~http~~://pdbe.org/5u0r PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5u0r RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5u0r PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0r ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0r OCA], [https://pdbe.org/5u0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u0r RCSB], [https://www.ebi.ac.uk/pdbsum/5u0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0r ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fera, D]]	+	[[Category: Fera D]]
-	[[Category: Harrison~~, S C]]~~	+	[[Category: Harrison SC]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab fragment]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 17:01, 11 December 2019

2019-12-11T17:01:47Z

←Older revision		Revision as of 17:01, 11 December 2019
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	==Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage==		==Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage==
-	<StructureSection load='5u0r' size='340' side='right' caption='[[5u0r]], [[Resolution\|resolution]] 3.29Å' scene=''>	+	<StructureSection load='5u0r' size='340' side='right'caption='[[5u0r]], [[Resolution\|resolution]] 3.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5u0r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U0R FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5u0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U0R FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tpl\|5tpl]], [[5tpp\|5tpp]], [[5tqa\|5tqa]], [[5trp\|5trp]], [[5u0u\|5u0u]], [[5u15\|5u15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tpl\|5tpl]], [[5tpp\|5tpp]], [[5tqa\|5tqa]], [[5trp\|5trp]], [[5u0u\|5u0u]], [[5u15\|5u15]]</td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fera, D]]		[[Category: Fera, D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 06:56, 29 March 2017

2017-03-29T06:56:08Z

←Older revision		Revision as of 06:56, 29 March 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0r OCA], [http://pdbe.org/5u0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u0r RCSB], [http://www.ebi.ac.uk/pdbsum/5u0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0r ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0r OCA], [http://pdbe.org/5u0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u0r RCSB], [http://www.ebi.ac.uk/pdbsum/5u0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0r ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic hypermutation (SHM) to acquire breadth, and current vaccine strategies have not been successful in inducing bnAbs. Because bnAbs directed against a glycosylated site adjacent to the third variable loop (V3) of the HIV-1 envelope protein require limited SHM, the V3-glycan epitope is an attractive vaccine target. By studying the cooperation among multiple V3-glycan B cell lineages and their coevolution with autologous virus throughout 5 years of infection, we identify key events in the ontogeny of a V3-glycan bnAb. Two autologous neutralizing antibody lineages selected for virus escape mutations and consequently allowed initiation and affinity maturation of a V3-glycan bnAb lineage. The nucleotide substitution required to initiate the bnAb lineage occurred at a low-probability site for activation-induced cytidine deaminase activity. Cooperation of B cell lineages and an improbable mutation critical for bnAb activity defined the necessary events leading to breadth in this V3-glycan bnAb lineage. These findings may, in part, explain why initiation of V3-glycan bnAbs is rare, and suggest an immunization strategy for inducing similar V3-glycan bnAbs.
		+
		+	Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.,Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, Xia SM, Cooper M, Louder MK, McKee K, Bailer RT, Pier BW, Jette CA, Kelsoe G, Williams WB, Morris L, Kappes J, Wagh K, Kamanga G, Cohen MS, Hraber PT, Montefiori DC, Trama A, Liao HX, Kepler TB, Moody MA, Gao F, Danishefsky SJ, Mascola JR, Shaw GM, Hahn BH, Harrison SC, Korber BT, Haynes BF Sci Transl Med. 2017 Mar 15;9(381). pii: eaai7514. doi:, 10.1126/scitranslmed.aai7514. PMID:28298420<ref>PMID:28298420</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5u0r" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:47, 15 March 2017

2017-03-15T21:47:31Z

←Older revision		Revision as of 21:47, 15 March 2017
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-	'''Unreleased structure'''

-	~~The entry 5u0r is ON HOLD until Paper Publication~~	+	==Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage==
-		+	<StructureSection load='5u0r' size='340' side='right' caption='[[5u0r]], [[Resolution\|resolution]] 3.29Å' scene=''>
-	~~Authors: Fera, D., Harrison, S.C.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5u0r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U0R FirstGlance]. <br>
-	~~Description:~~ Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5tpl\|5tpl]], [[5tpp\|5tpp]], [[5tqa\|5tqa]], [[5trp\|5trp]], [[5u0u\|5u0u]], [[5u15\|5u15]]</td></tr>
-	[[~~Category~~: ~~Harrison~~, S.C]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u0r OCA], [http://pdbe.org/5u0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u0r RCSB], [http://www.ebi.ac.uk/pdbsum/5u0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u0r ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fera, D]]		[[Category: Fera, D]]
		+	[[Category: Harrison, S C]]
		+	[[Category: Antibody]]
		+	[[Category: Fab fragment]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]

OCA at 14:17, 18 January 2017

2017-01-18T14:17:51Z

←Older revision		Revision as of 14:17, 18 January 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5u0r is ON HOLD	+	The entry 5u0r is ON HOLD until Paper Publication

	Authors: Fera, D., Harrison, S.C.		Authors: Fera, D., Harrison, S.C.

OCA: Protected "5u0r" [edit=sysop:move=sysop]

2016-12-09T18:09:33Z

Protected "5u0r" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:09, 9 December 2016

OCA: New page: '''Unreleased structure''' The entry 5u0r is ON HOLD Authors: Fera, D., Harrison, S.C. Description: Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N33...

2016-12-09T18:09:32Z

New page: '''Unreleased structure''' The entry 5u0r is ON HOLD Authors: Fera, D., Harrison, S.C. Description: Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N33...

New page

'''Unreleased structure'''

The entry 5u0r is ON HOLD

Authors: Fera, D., Harrison, S.C.

Description: Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
[[Category: Unreleased Structures]]
[[Category: Harrison, S.C]]
[[Category: Fera, D]]