5uc0 - Revision history

OCA at 09:14, 1 January 2020

2020-01-01T09:14:55Z

←Older revision		Revision as of 09:14, 1 January 2020
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	==Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus==		==Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus==
-	<StructureSection load='5uc0' size='340' side='right' caption='[[5uc0]], [[Resolution\|resolution]] 1.73Å' scene=''>	+	<StructureSection load='5uc0' size='340' side='right'caption='[[5uc0]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5uc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brua2 Brua2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC0 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5uc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brua2 Brua2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC0 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Brua2]]		[[Category: Brua2]]
		+	[[Category: Large Structures]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
	[[Category: Bigelow, L]]		[[Category: Bigelow, L]]

OCA at 08:43, 19 December 2018

2018-12-19T08:43:18Z

←Older revision		Revision as of 08:43, 19 December 2018
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc0 OCA], [http://pdbe.org/5uc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc0 OCA], [http://pdbe.org/5uc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc0 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Molecular components of the Brucella abortus cell envelope play a major role in its ability to infect, colonize and survive inside mammalian host cells. In this study, we have defined a role for a conserved gene of unknown function in B. abortus envelope stress resistance and infection. Expression of this gene, which we name eipA, is directly activated by the essential cell cycle regulator, CtrA. eipA encodes a soluble periplasmic protein that adopts an unusual eight-stranded beta-barrel fold. Deletion of eipA attenuates replication and survival in macrophage and mouse infection models, and results in sensitivity to treatments that compromise the cell envelope integrity. Transposon disruption of genes required for LPS O-polysaccharide biosynthesis is synthetically lethal with eipA deletion. This genetic connection between O-polysaccharide and eipA is corroborated by our discovery that eipA is essential in Brucella ovis, a naturally rough species that harbors mutations in several genes required for O-polysaccharide production. Conditional depletion of eipA expression in B. ovis results in a cell chaining phenotype, providing evidence that eipA directly or indirectly influences cell division in Brucella. We conclude that EipA is a molecular determinant of Brucella virulence that functions to maintain cell envelope integrity and influences cell division. This article is protected by copyright. All rights reserved.
		+
		+	Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.,Herrou J, Willett JW, Fiebig A, Varesio LM, Czyz DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, Crosson S Mol Microbiol. 2018 Dec 8. doi: 10.1111/mmi.14178. PMID:30536925<ref>PMID:30536925</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5uc0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:47, 24 January 2018

2018-01-24T20:47:48Z

←Older revision		Revision as of 20:47, 24 January 2018
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	</StructureSection>		</StructureSection>
	[[Category: Brua2]]		[[Category: Brua2]]
-	[[Category: Annotation, Chicago Center for Functional]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
	[[Category: Bigelow, L]]		[[Category: Bigelow, L]]

OCA at 09:26, 1 November 2017

2017-11-01T09:26:07Z

←Older revision		Revision as of 09:26, 1 November 2017
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	<StructureSection load='5uc0' size='340' side='right' caption='[[5uc0]], [[Resolution\|resolution]] 1.73Å' scene=''>		<StructureSection load='5uc0' size='340' side='right' caption='[[5uc0]], [[Resolution\|resolution]] 1.73Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uc0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brua2 Brua2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAB1_1612 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=359391 BRUA2])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc0 OCA], [http://pdbe.org/5uc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc0 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc0 OCA], [http://pdbe.org/5uc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc0 ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Brua2]]
	[[Category: Annotation, Chicago Center for Functional]]		[[Category: Annotation, Chicago Center for Functional]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]

OCA at 07:56, 9 March 2017

2017-03-09T07:56:20Z

←Older revision		Revision as of 07:56, 9 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5uc0 ~~is ON HOLD~~	+	==Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus==
-		+	<StructureSection load='5uc0' size='340' side='right' caption='[[5uc0]], [[Resolution\|resolution]] 1.73Å' scene=''>
-	~~Authors~~: ~~Kim, Y~~.~~, Bigelow, L~~.~~, Endres, M~~.~~, Babnigg, G~~.~~, Crosson, S~~.~~, Joachimiak, A~~., ~~Chicago Center for Functional Annotation~~, ~~Midwest Center for Structural Genomics (MCSG)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5uc0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UC0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UC0 FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of Beta~~-~~barrel~~-~~like Protein of Unknown Function~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Joachimiak~~, A]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uc0 OCA], [http://pdbe.org/5uc0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uc0 RCSB], [http://www.ebi.ac.uk/pdbsum/5uc0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uc0 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Annotation, Chicago Center for Functional]]
	[[Category: Babnigg, G]]		[[Category: Babnigg, G]]
		+	[[Category: Bigelow, L]]
	[[Category: Crosson, S]]		[[Category: Crosson, S]]
-	[[Category: ~~Chicago Center For Functional Annotation~~, ~~Midwest Center For Structural Genomics (Mcsg)~~]]	+	[[Category: Endres, M]]
-	[[Category: ~~Bigelow~~, L]]	+	[[Category: Joachimiak, A]]
	[[Category: Kim, Y]]		[[Category: Kim, Y]]
-	[[Category: ~~Endres, M~~]]	+	[[Category: Structural genomic]]
		+	[[Category: Beta barrel-like]]
		+	[[Category: Beta-structure]]
		+	[[Category: Chicago center for functional annotation]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mcsg]]
		+	[[Category: Psi-biology]]

OCA: Protected "5uc0" [edit=sysop:move=sysop]

2017-01-02T15:20:41Z

Protected "5uc0" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:20, 2 January 2017

OCA: New page: '''Unreleased structure''' The entry 5uc0 is ON HOLD Authors: Kim, Y., Bigelow, L., Endres, M., Babnigg, G., Crosson, S., Joachimiak, A., Chicago Center for Functional Annotation, Midwe...

2017-01-02T15:20:40Z

New page: '''Unreleased structure''' The entry 5uc0 is ON HOLD Authors: Kim, Y., Bigelow, L., Endres, M., Babnigg, G., Crosson, S., Joachimiak, A., Chicago Center for Functional Annotation, Midwe...

New page

'''Unreleased structure'''

The entry 5uc0 is ON HOLD

Authors: Kim, Y., Bigelow, L., Endres, M., Babnigg, G., Crosson, S., Joachimiak, A., Chicago Center for Functional Annotation, Midwest Center for Structural Genomics (MCSG)

Description: Crystal Structure of Beta-barrel-like Protein of Unknown Function
[[Category: Unreleased Structures]]
[[Category: Joachimiak, A]]
[[Category: Babnigg, G]]
[[Category: Crosson, S]]
[[Category: Chicago Center For Functional Annotation, Midwest Center For Structural Genomics (Mcsg)]]
[[Category: Bigelow, L]]
[[Category: Kim, Y]]
[[Category: Endres, M]]