5udq - Revision history

OCA at 07:57, 27 November 2019

2019-11-27T07:57:38Z

←Older revision		Revision as of 07:57, 27 November 2019
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	==LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form==		==LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form==
-	<StructureSection load='5udq' size='340' side='right' caption='[[5udq]], [[Resolution\|resolution]] 2.09Å' scene=''>	+	<StructureSection load='5udq' size='340' side='right'caption='[[5udq]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5udq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[5udq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDQ FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Lacpl]]		[[Category: Lacpl]]
		+	[[Category: Large Structures]]
	[[Category: Desguin, B]]		[[Category: Desguin, B]]
	[[Category: Fellner, M]]		[[Category: Fellner, M]]

OCA at 21:04, 15 November 2017

2017-11-15T21:04:38Z

←Older revision		Revision as of 21:04, 15 November 2017
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	<StructureSection load='5udq' size='340' side='right' caption='[[5udq]], [[Resolution\|resolution]] 2.09Å' scene=''>		<StructureSection load='5udq' size='340' side='right' caption='[[5udq]], [[Resolution\|resolution]] 2.09Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5udq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5udq]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lacpl Lacpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5udr\|5udr]], [[5uds\|5uds]], [[5udt\|5udt]], [[5udu\|5udu]], [[5udv\|5udv]], [[5udw\|5udw]], [[5udx\|5udx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5udr\|5udr]], [[5uds\|5uds]], [[5udt\|5udt]], [[5udu\|5udu]], [[5udv\|5udv]], [[5udw\|5udw]], [[5udx\|5udx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">larE, lp_0109 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220668 LACPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5udq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udq OCA], [http://pdbe.org/5udq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5udq RCSB], [http://www.ebi.ac.uk/pdbsum/5udq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5udq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5udq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udq OCA], [http://pdbe.org/5udq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5udq RCSB], [http://www.ebi.ac.uk/pdbsum/5udq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5udq ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lacpl]]
	[[Category: Desguin, B]]		[[Category: Desguin, B]]
	[[Category: Fellner, M]]		[[Category: Fellner, M]]

OCA at 11:02, 24 August 2017

2017-08-24T11:02:52Z

←Older revision		Revision as of 11:02, 24 August 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5udq is ~~ON HOLD until Paper~~ Publication	+	==LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase, apo form==
		+	<StructureSection load='5udq' size='340' side='right' caption='[[5udq]], [[Resolution\|resolution]] 2.09Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5udq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UDQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5udr\|5udr]], [[5uds\|5uds]], [[5udt\|5udt]], [[5udu\|5udu]], [[5udv\|5udv]], [[5udw\|5udw]], [[5udx\|5udx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5udq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5udq OCA], [http://pdbe.org/5udq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5udq RCSB], [http://www.ebi.ac.uk/pdbsum/5udq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5udq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The lar operon in Lactobacillus plantarum encodes five Lar proteins (LarA/B/C/D/E) that collaboratively synthesize and incorporate a niacin-derived Ni-containing cofactor into LarA, an Ni-dependent lactate racemase. Previous studies have established that two molecules of LarE catalyze successive thiolation reactions by donating the sulfur atom of their exclusive cysteine residues to the substrate. However, the catalytic mechanism of this very unusual sulfur-sacrificing reaction remains elusive. In this work, we present the crystal structures of LarE in ligand-free and several ligand-bound forms, demonstrating that LarE is a member of the N-type ATP pyrophosphatase (PPase) family with a conserved N-terminal ATP PPase domain and a unique C-terminal domain harboring the putative catalytic site. Structural analysis, combined with structure-guided mutagenesis, leads us to propose a catalytic mechanism that establishes LarE as a paradigm for sulfur transfer through sacrificing its catalytic cysteine residue.

-	~~Authors~~:	+	Structural insights into the catalytic mechanism of a sacrificial sulfur insertase of the N-type ATP pyrophosphatase family, LarE.,Fellner M, Desguin B, Hausinger RP, Hu J Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9074-9079. doi:, 10.1073/pnas.1704967114. Epub 2017 Aug 7. PMID:28784764<ref>PMID:28784764</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5udq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Desguin, B]]
		+	[[Category: Fellner, M]]
		+	[[Category: Hausinger, R P]]
		+	[[Category: Hu, J]]
		+	[[Category: Ampylation]]
		+	[[Category: Atp pyrophophatase domain]]
		+	[[Category: Hexamer]]
		+	[[Category: Lactate]]
		+	[[Category: Lactate racemase]]
		+	[[Category: Lactate racemization]]
		+	[[Category: Lar]]
		+	[[Category: Lare]]
		+	[[Category: Pp-loop]]
		+	[[Category: Sulfur transferase]]
		+	[[Category: Transferase]]
		+	[[Category: Trimer]]

OCA at 14:43, 18 January 2017

2017-01-18T14:43:58Z

←Older revision		Revision as of 14:43, 18 January 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5udq is ON HOLD	+	The entry 5udq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5udq" [edit=sysop:move=sysop]

2017-01-04T15:43:06Z

Protected "5udq" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:43, 4 January 2017

OCA: New page: '''Unreleased structure''' The entry 5udq is ON HOLD Authors: Description: Category: Unreleased Structures

2017-01-04T15:43:04Z

New page: '''Unreleased structure''' The entry 5udq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5udq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]