5umw - Revision history

OCA at 11:19, 23 September 2020

2020-09-23T11:19:22Z

←Older revision		Revision as of 11:19, 23 September 2020
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	==Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234==		==Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234==
-	<StructureSection load='5umw' size='340' side='right' caption='[[5umw]], [[Resolution\|resolution]] 2.27Å' scene=''>	+	<StructureSection load='5umw' size='340' side='right'caption='[[5umw]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5umw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._cb03234 Streptomyces sp. cb03234]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5umw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._cb03234 Streptomyces sp. cb03234]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UMW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tnmS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1703937 Streptomyces sp. CB03234])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tnmS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1703937 Streptomyces sp. CB03234])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5umw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umw OCA], [http://pdbe.org/5umw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umw RCSB], [http://www.ebi.ac.uk/pdbsum/5umw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5umw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umw OCA], [http://pdbe.org/5umw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umw RCSB], [http://www.ebi.ac.uk/pdbsum/5umw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5umw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5umw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dioxygenase 3D structures\|Dioxygenase 3D structures]]
		+	*[[Glyoxalase 3D structures\|Glyoxalase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Streptomyces sp. cb03234]]		[[Category: Streptomyces sp. cb03234]]
	[[Category: Chang, C]]		[[Category: Chang, C]]

OCA at 06:06, 11 July 2018

2018-07-11T06:06:18Z

←Older revision		Revision as of 06:06, 11 July 2018
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	<StructureSection load='5umw' size='340' side='right' caption='[[5umw]], [[Resolution\|resolution]] 2.27Å' scene=''>		<StructureSection load='5umw' size='340' side='right' caption='[[5umw]], [[Resolution\|resolution]] 2.27Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5umw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5umw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_sp._cb03234 Streptomyces sp. cb03234]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UMW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">tnmS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1703937 Streptomyces sp. CB03234])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5umw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umw OCA], [http://pdbe.org/5umw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umw RCSB], [http://www.ebi.ac.uk/pdbsum/5umw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5umw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umw OCA], [http://pdbe.org/5umw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umw RCSB], [http://www.ebi.ac.uk/pdbsum/5umw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umw ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The enediynes, microbial natural products with extraordinary cytotoxicities, have been translated into clinical drugs. Two self-resistance mechanisms are known in the enediyne producers-apoproteins for the nine-membered enediynes and self-sacrifice proteins for the ten-membered enediyne calicheamicin. Here we show that: (1) tnmS1, tnmS2, and tnmS3 encode tiancimycin (TNM) resistance in its producer Streptomyces sp. CB03234, (2) tnmS1, tnmS2, and tnmS3 homologs are found in all anthraquinone-fused enediyne producers, (3) TnmS1, TnmS2, and TnmS3 share a similar beta barrel-like structure, bind TNMs with nanomolar KD values, and confer resistance by sequestration, and (4) TnmS1, TnmS2, and TnmS3 homologs are widespread in nature, including in the human microbiome. These findings unveil an unprecedented resistance mechanism for the enediynes. Mechanisms of self-resistance in producers serve as models to predict and combat future drug resistance in clinical settings. Enediyne-based chemotherapies should now consider the fact that the human microbiome harbors genes encoding enediyne resistance.
		+
		+	Resistance to Enediyne Antitumor Antibiotics by Sequestration.,Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B Cell Chem Biol. 2018 May 29. pii: S2451-9456(18)30183-1. doi:, 10.1016/j.chembiol.2018.05.012. PMID:29937405<ref>PMID:29937405</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5umw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Streptomyces sp. cb03234]]
	[[Category: Chang, C]]		[[Category: Chang, C]]
	[[Category: Chang, C Y]]		[[Category: Chang, C Y]]

OCA at 07:04, 4 July 2018

2018-07-04T07:04:21Z

←Older revision		Revision as of 07:04, 4 July 2018
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-	'''Unreleased structure'''

-	~~The entry 5umw is ON HOLD until Jul 29 2019~~	+	==Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234==
-		+	<StructureSection load='5umw' size='340' side='right' caption='[[5umw]], [[Resolution\|resolution]] 2.27Å' scene=''>
-	Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5umw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UMW FirstGlance]. <br>
-	~~Description:~~ Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RBF:RIBOFLAVIN'>RBF</scene></td></tr>
-	[[~~Category: Unreleased Structures~~]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[~~Category~~: ~~Phillips, G~~.N]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5umw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5umw OCA], [http://pdbe.org/5umw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5umw RCSB], [http://www.ebi.ac.uk/pdbsum/5umw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5umw ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Chang, C.Y~~]]	+	</table>
-	[[~~Category~~: ~~Enzyme Discovery For Natural Product Biosynthesis (Natpro)~~, ~~Midwest Center For Structural Genomics (Mcsg)~~]]	+	__TOC__
		+	</StructureSection>
	[[Category: Chang, C]]		[[Category: Chang, C]]
		+	[[Category: Chang, C Y]]
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]
-	[[Category: ~~Rudolf~~, ~~J.D~~]]	+	[[Category: Structural genomic]]
		+	[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
	[[Category: Nocek, B]]		[[Category: Nocek, B]]
		+	[[Category: Phillips, G N]]
		+	[[Category: Rudolf, J D]]
	[[Category: Shen, B]]		[[Category: Shen, B]]
		+	[[Category: Enzyme discovery for natural product biosynthesis]]
		+	[[Category: Glyoxalase/bleomycin resistance protein/dioxygenase superfamily]]
		+	[[Category: Mcsg]]
		+	[[Category: Natpro]]
		+	[[Category: Psi-biology]]
		+	[[Category: Tiancimycin-binding protein]]

OCA at 05:53, 6 December 2017

2017-12-06T05:53:23Z

←Older revision		Revision as of 05:53, 6 December 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5umw is ON HOLD until ~~Paper Publication~~	+	The entry 5umw is ON HOLD until Jul 29 2019

	Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)		Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)
Line 10:		Line 10:
	[[Category: Chang, C.Y]]		[[Category: Chang, C.Y]]
	[[Category: Enzyme Discovery For Natural Product Biosynthesis (Natpro), Midwest Center For Structural Genomics (Mcsg)]]		[[Category: Enzyme Discovery For Natural Product Biosynthesis (Natpro), Midwest Center For Structural Genomics (Mcsg)]]
		+	[[Category: Chang, C]]
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]
		+	[[Category: Rudolf, J.D]]
	[[Category: Nocek, B]]		[[Category: Nocek, B]]
	[[Category: Shen, B]]		[[Category: Shen, B]]
-	[[Category: Rudolf, J.D]]
-	[[Category: Chang, C]]

OCA at 13:44, 27 September 2017

2017-09-27T13:44:57Z

←Older revision		Revision as of 13:44, 27 September 2017
Line 12:		Line 12:
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]
	[[Category: Nocek, B]]		[[Category: Nocek, B]]
-	[[Category: Rudolf, J.D]]
	[[Category: Shen, B]]		[[Category: Shen, B]]
		+	[[Category: Rudolf, J.D]]
	[[Category: Chang, C]]		[[Category: Chang, C]]

OCA at 19:12, 15 March 2017

2017-03-15T19:12:11Z

←Older revision		Revision as of 19:12, 15 March 2017
Line 12:		Line 12:
	[[Category: Joachimiak, A]]		[[Category: Joachimiak, A]]
	[[Category: Nocek, B]]		[[Category: Nocek, B]]
-	[[Category: Shen, B]]
	[[Category: Rudolf, J.D]]		[[Category: Rudolf, J.D]]
		+	[[Category: Shen, B]]
	[[Category: Chang, C]]		[[Category: Chang, C]]

OCA: Protected "5umw" [edit=sysop:move=sysop]

2017-03-09T14:37:59Z

Protected "5umw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:37, 9 March 2017

OCA: New page: '''Unreleased structure''' The entry 5umw is ON HOLD until Paper Publication Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme D...

2017-03-09T14:37:58Z

New page: '''Unreleased structure''' The entry 5umw is ON HOLD until Paper Publication Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme D...

New page

'''Unreleased structure'''

The entry 5umw is ON HOLD until Paper Publication

Authors: Chang, C.Y., Chang, C., Nocek, B., Rudolf, J.D., Joachimiak, A., Phillips, G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro), Midwest Center for Structural Genomics (MCSG)

Description: Crystal structure of TnmS2, an antibiotic binding protein from Streptomyces sp. CB03234
[[Category: Unreleased Structures]]
[[Category: Phillips, G.N]]
[[Category: Chang, C.Y]]
[[Category: Enzyme Discovery For Natural Product Biosynthesis (Natpro), Midwest Center For Structural Genomics (Mcsg)]]
[[Category: Joachimiak, A]]
[[Category: Nocek, B]]
[[Category: Shen, B]]
[[Category: Rudolf, J.D]]
[[Category: Chang, C]]