5uxe - Revision history

OCA at 13:36, 4 October 2023

2023-10-04T13:36:53Z

←Older revision		Revision as of 13:36, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5uxe' size='340' side='right'caption='[[5uxe]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5uxe' size='340' side='right'caption='[[5uxe]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uxe]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus~~ perfringens~~" veillon and zuber 1898~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5UXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uxe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UXE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uwx\|5uwx]], [[4q32\|4q32]], [[4q33\|4q33]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">guaB_2, guaB, ERS852446_02285, JFP838_13815 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 "Bacillus perfringens" Veillon and Zuber 1898])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxe OCA], [https://pdbe.org/5uxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uxe RCSB], [https://www.ebi.ac.uk/pdbsum/5uxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxe ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5uxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxe OCA], [~~http~~://pdbe.org/5uxe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5uxe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5uxe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxe ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]	+	[https://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]

	==See Also==		==See Also==
Line 17:		Line 15:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ perfringens ~~veillon and zuber 1898]]~~	+	[[Category: Clostridium perfringens]]
-	~~[[Category: IMP dehydrogenase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Anderson~~, W F]]~~	+	[[Category: Anderson WF]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Gollapalli DR]]
-	[[Category: Gollapalli~~, D R~~]]	+	[[Category: Gu M]]
-	[[Category: Gu, M]]	+	[[Category: Hedstrom L]]
-	[[Category: Hedstrom, L]]	+	[[Category: Joachimiak A]]
-	[[Category: Joachimiak, A]]	+	[[Category: Kim Y]]
-	[[Category: Kim, Y]]	+	[[Category: Makowska-Grzyska M]]
-	[[Category: Makowska-Grzyska, M]]	+	[[Category: Maltseva N]]
-	[[Category: Maltseva, N]]	+	[[Category: Mulligan R]]
-	[[Category: Mulligan, R]]	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Dehydrogenase]]~~	+
-	~~[[Category: Impdh]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Tim barrel~~]]	+

OCA at 08:26, 30 September 2020

2020-09-30T08:26:04Z

←Older revision		Revision as of 08:26, 30 September 2020
Line 1:		Line 1:

	==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P178==		==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P178==
-	<StructureSection load='5uxe' size='340' side='right' caption='[[5uxe]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5uxe' size='340' side='right'caption='[[5uxe]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5uxe]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5UXE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5uxe]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_perfringens"_veillon_and_zuber_1898 "bacillus perfringens" veillon and zuber 1898]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UXE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uwx\|5uwx]], [[4q32\|4q32]], [[4q33\|4q33]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5uwx\|5uwx]], [[4q32\|4q32]], [[4q33\|4q33]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">guaB_2, guaB, ERS852446_02285, JFP838_13815 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1502 "Bacillus perfringens" Veillon and Zuber 1898])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5uxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxe OCA], [http://pdbe.org/5uxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uxe RCSB], [http://www.ebi.ac.uk/pdbsum/5uxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxe OCA], [http://pdbe.org/5uxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uxe RCSB], [http://www.ebi.ac.uk/pdbsum/5uxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]		[[http://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
		+
		+	==See Also==
		+	*[[Inosine monophosphate dehydrogenase 3D structures\|Inosine monophosphate dehydrogenase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus perfringens veillon and zuber 1898]]
	[[Category: IMP dehydrogenase]]		[[Category: IMP dehydrogenase]]
		+	[[Category: Large Structures]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA: Protected "5uxe" [edit=sysop:move=sysop]

2017-03-11T19:21:04Z

Protected "5uxe" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:21, 11 March 2017

OCA: New page: ==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P178== <StructureSection load='5uxe' size='340' side='right' caption='[[5uxe]], [[Resolution|resolution]] 2.10Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5uxe]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UXE OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UXE FirstGlance]. 
</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=8LA:N-[4-CHLORO-3-(ALPHA-D-RIBOFURANOSYLOXY)PHENYL]-N-{2-[3-(PROP-1-EN-2-YL)PHENYL]PROPAN-2-YL}UREA'>8LA</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5uwx|5uwx]], [[4q32|4q32]], [[4q33|4q33]]</td></tr>
<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </td></tr>
<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uxe OCA], [http://pdbe.org/5uxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uxe RCSB], [http://www.ebi.ac.uk/pdbsum/5uxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uxe ProSAT]</td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/A0A127ELD1_CLOPF A0A127ELD1_CLOPF]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
TOC
</StructureSection>
[[Category: IMP dehydrogenase]]
[[Category: Anderson, W F]]
[[Category: Structural genomic]]
[[Category: Gollapalli, D R]]
[[Category: Gu, M]]
[[Category: Hedstrom, L]]
[[Category: Joachimiak, A]]
[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Maltseva, N]]
[[Category: Mulligan, R]]
[[Category: Csgid]]
[[Category: Dehydrogenase]]
[[Category: Impdh]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tim barrel]]