5v70 - Revision history

OCA at 13:42, 4 October 2023

2023-10-04T13:42:58Z

←Older revision		Revision as of 13:42, 4 October 2023
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	<StructureSection load='5v70' size='340' side='right'caption='[[5v70]], [[Resolution\|resolution]] 1.94Å' scene=''>		<StructureSection load='5v70' size='340' side='right'caption='[[5v70]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v70]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V70 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5V70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v70]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5V70 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.94Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v73\|5v73]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5v70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v70 OCA], [~~http~~://pdbe.org/5v70 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5v70 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5v70 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5v70 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5v70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v70 OCA], [https://pdbe.org/5v70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5v70 RCSB], [https://www.ebi.ac.uk/pdbsum/5v70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5v70 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>

	==See Also==		==See Also==
Line 19:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lolis, E]]	+	[[Category: Lolis E]]
-	[[Category: Pantouris, G]]	+	[[Category: Pantouris G]]
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Mutation]]~~	+
-	~~[[Category: Trimeric~~]]	+

OCA at 08:31, 30 September 2020

2020-09-30T08:31:55Z

←Older revision		Revision as of 08:31, 30 September 2020
Line 1:		Line 1:

	==Crystal structure of N102A mutant of human macrophage migration inhibitory factor==		==Crystal structure of N102A mutant of human macrophage migration inhibitory factor==
-	<StructureSection load='5v70' size='340' side='right' caption='[[5v70]], [[Resolution\|resolution]] 1.94Å' scene=''>	+	<StructureSection load='5v70' size='340' side='right'caption='[[5v70]], [[Resolution\|resolution]] 1.94Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5v70]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V70 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5V70 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5v70]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V70 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5V70 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v73\|5v73]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v73\|5v73]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5v70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v70 OCA], [http://pdbe.org/5v70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v70 RCSB], [http://www.ebi.ac.uk/pdbsum/5v70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v70 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5v70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v70 OCA], [http://pdbe.org/5v70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v70 RCSB], [http://www.ebi.ac.uk/pdbsum/5v70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v70 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 12:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]

OCA at 07:32, 21 March 2018

2018-03-21T07:32:25Z

←Older revision		Revision as of 07:32, 21 March 2018
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5v70 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of N102A mutant of human macrophage migration inhibitory factor==
-		+	<StructureSection load='5v70' size='340' side='right' caption='[[5v70]], [[Resolution\|resolution]] 1.94Å' scene=''>
-	~~Authors~~: ~~Pantouris~~, G., ~~Lolis~~, E.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5v70]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V70 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of ~~N102A mutant~~ of ~~human macrophage migration inhibitory factor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5v73\|5v73]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v70 OCA], [http://pdbe.org/5v70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v70 RCSB], [http://www.ebi.ac.uk/pdbsum/5v70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v70 ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Lolis, E]]		[[Category: Lolis, E]]
	[[Category: Pantouris, G]]		[[Category: Pantouris, G]]
		+	[[Category: Isomerase]]
		+	[[Category: Mutation]]
		+	[[Category: Trimeric]]

OCA: Protected "5v70" [edit=sysop:move=sysop]

2017-04-05T11:40:42Z

Protected "5v70" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:40, 5 April 2017

OCA: New page: '''Unreleased structure''' The entry 5v70 is ON HOLD until Paper Publication Authors: Pantouris, G., Lolis, E. Description: Crystal structure of N102A mutant of human macrophage migrat...

2017-04-05T11:40:40Z

New page: '''Unreleased structure''' The entry 5v70 is ON HOLD until Paper Publication Authors: Pantouris, G., Lolis, E. Description: Crystal structure of N102A mutant of human macrophage migrat...

New page

'''Unreleased structure'''

The entry 5v70 is ON HOLD until Paper Publication

Authors: Pantouris, G., Lolis, E.

Description: Crystal structure of N102A mutant of human macrophage migration inhibitory factor
[[Category: Unreleased Structures]]
[[Category: Lolis, E]]
[[Category: Pantouris, G]]