5veo - Revision history

OCA at 08:26, 8 January 2020

2020-01-08T08:26:05Z

←Older revision		Revision as of 08:26, 8 January 2020
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	==Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5), inactive (T72A), in complex with AMP==		==Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5), inactive (T72A), in complex with AMP==
-	<StructureSection load='5veo' size='340' side='right' caption='[[5veo]], [[Resolution\|resolution]] 1.53Å' scene=''>	+	<StructureSection load='5veo' size='340' side='right'caption='[[5veo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5veo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEO FirstGlance]. <br>		<table><tr><td colspan='2'>[[5veo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEO FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5veo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5veo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures\|Ectonucleotide pyrophosphatase/phosphodiesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Gorelik, A]]		[[Category: Gorelik, A]]

OCA at 10:29, 22 November 2017

2017-11-22T10:29:51Z

←Older revision		Revision as of 10:29, 22 November 2017
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	<StructureSection load='5veo' size='340' side='right' caption='[[5veo]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='5veo' size='340' side='right' caption='[[5veo]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5veo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5veo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vem\|5vem]], [[5ven\|5ven]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vem\|5vem]], [[5ven\|5ven]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Enpp5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veo OCA], [http://pdbe.org/5veo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veo RCSB], [http://www.ebi.ac.uk/pdbsum/5veo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veo ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veo OCA], [http://pdbe.org/5veo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veo RCSB], [http://www.ebi.ac.uk/pdbsum/5veo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veo ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Gorelik, A]]		[[Category: Gorelik, A]]
	[[Category: Illes, K]]		[[Category: Illes, K]]

OCA at 04:44, 21 September 2017

2017-09-21T04:44:14Z

←Older revision		Revision as of 04:44, 21 September 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5veo is ~~ON HOLD until Paper~~ Publication	+	==Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5), inactive (T72A), in complex with AMP==
		+	<StructureSection load='5veo' size='340' side='right' caption='[[5veo]], [[Resolution\|resolution]] 1.53Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5veo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vem\|5vem]], [[5ven\|5ven]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veo OCA], [http://pdbe.org/5veo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veo RCSB], [http://www.ebi.ac.uk/pdbsum/5veo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veo ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ENPP5_MOUSE ENPP5_MOUSE]] May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity).[UniProtKB:P84039]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ecto-nucleotide pyrophosphatase / phosphodiesterase (NPP) family of proteins mediates purinergic signaling by degrading extracellular nucleotides, and also participates in phospholipid metabolism. NPP5 (ENPP5) is the least characterized member of this group and its specific role is unknown. This enzyme does not display activity on certain nucleotides and on other typical NPP substrates. In order to gain insights into its function, we determined the crystal structure of human and murine NPP5. Structural comparison with close homologs revealed a key phenylalanine to tyrosine substitution that prevents efficient hydrolysis of nucleotide diphosphates and triphosphates; reversal of this mutation enabled degradation of these molecules. Interestingly, NPP5 is able to cleave nicotinamide adenine dinucleotide (NAD), suggesting a potential role of this enzyme in NAD-based neurotransmission. An NPP5-specific metal binding motif is found adjacent to the active site, although its significance is unclear. These findings expand our understanding of substrate specificity within the NPP family. This article is protected by copyright. All rights reserved.

-	~~Authors~~:	+	A Key Tyrosine Substitution Restricts Nucleotide Hydrolysis by the Ectoenzyme NPP5.,Gorelik A, Randriamihaja A, Illes K, Nagar B FEBS J. 2017 Sep 12. doi: 10.1111/febs.14266. PMID:28898552<ref>PMID:28898552</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5veo" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gorelik, A]]
		+	[[Category: Illes, K]]
		+	[[Category: Nagar, B]]
		+	[[Category: Randriamihaja, A]]
		+	[[Category: Hydrolase]]

OCA at 12:13, 27 April 2017

2017-04-27T12:13:20Z

←Older revision		Revision as of 12:13, 27 April 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5veo is ON HOLD	+	The entry 5veo is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5veo" [edit=sysop:move=sysop]

2017-04-12T09:59:02Z

Protected "5veo" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:59, 12 April 2017

OCA: New page: '''Unreleased structure''' The entry 5veo is ON HOLD Authors: Description: Category: Unreleased Structures

2017-04-12T09:59:01Z

New page: '''Unreleased structure''' The entry 5veo is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5veo is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]