5veu - Revision history

OCA at 13:47, 4 October 2023

2023-10-04T13:47:26Z

←Older revision		Revision as of 13:47, 4 October 2023
Line 3:		Line 3:
	<StructureSection load='5veu' size='340' side='right'caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='5veu' size='340' side='right'caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VEU FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene~~>, ~~<scene name='pdbligand=RIT:RITONAVIR'>RIT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.91Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>CYP3A5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veu OCA], [https://pdbe.org/5veu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5veu RCSB], [https://www.ebi.ac.uk/pdbsum/5veu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5veu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veu OCA], [~~http~~://pdbe.org/5veu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5veu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5veu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5veu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Tacrolimus dose selection.	+	[https://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN] Tacrolimus dose selection.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	+	[https://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Unspecific monooxygenase]]~~	+	[[Category: Hsu M-H]]
-	[[Category: Hsu, M H]]	+	[[Category: Johnson EF]]
-	[[Category: Johnson~~, E F]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Cyp3a5]]~~	+
-	~~[[Category: Cytochrome p450]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]~~	+
-	~~[[Category: Ritonavir~~]]	+

OCA at 09:32, 1 January 2020

2020-01-01T09:32:51Z

←Older revision		Revision as of 09:32, 1 January 2020
Line 1:		Line 1:

	==Human Cytochrome P450 3A5 (CYP3A5)==		==Human Cytochrome P450 3A5 (CYP3A5)==
-	<StructureSection load='5veu' size='340' side='right' caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>	+	<StructureSection load='5veu' size='340' side='right'caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEU FirstGlance]. <br>		<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEU FirstGlance]. <br>
Line 22:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5veu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5veu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Hsu, M H]]		[[Category: Hsu, M H]]

OCA at 07:32, 13 December 2017

2017-12-13T07:32:25Z

←Older revision		Revision as of 07:32, 13 December 2017
Line 3:		Line 3:
	<StructureSection load='5veu' size='340' side='right' caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='5veu' size='340' side='right' caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP3A5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veu OCA], [http://pdbe.org/5veu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veu RCSB], [http://www.ebi.ac.uk/pdbsum/5veu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veu OCA], [http://pdbe.org/5veu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veu RCSB], [http://www.ebi.ac.uk/pdbsum/5veu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veu ProSAT]</span></td></tr>
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Unspecific monooxygenase]]		[[Category: Unspecific monooxygenase]]
	[[Category: Hsu, M H]]		[[Category: Hsu, M H]]

OCA at 07:32, 15 November 2017

2017-11-15T07:32:04Z

←Older revision		Revision as of 07:32, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5veu is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Human Cytochrome P450 3A5 (CYP3A5)==
		+	<StructureSection load='5veu' size='340' side='right' caption='[[5veu]], [[Resolution\|resolution]] 2.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5veu]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VEU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5veu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5veu OCA], [http://pdbe.org/5veu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5veu RCSB], [http://www.ebi.ac.uk/pdbsum/5veu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5veu ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Tacrolimus dose selection.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP3A5_HUMAN CP3A5_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Contributions of cytochrome P450 3A5 to the metabolic clearance of marketed drugs is unclear, but is likely to augment the metabolism of several drugs that are largely cleared by P450 3A4. Selective metabolism by 3A4 is often a concern in drug development due to potential drug-drug interactions and the variability of 3A4 and 3A5 expression. The contribution of P450 3A5 to these clearance pathways varies between individuals due to genetic differences and similarities and differences in the metabolic properties of 3A5 compared to 3A4. To better understand the structural differences between P450s 3A4 and 3A5, the structure of 3A5 complexed with ritonavir was determined by X-ray crystallography to limiting resolution of 2.91A. The secondary and tertiary structures of 3A5 and 3A4 are similar, but the architectures of their active sites differ. The 3A5 active site is taller and narrower than that of 3A4. As a result, ritonavir adopts a distinctly different conformation to fit into the cavity of 3A5 than seen for 3A4. These structural changes reflect amino acid differences that alter the conformation of the helix F through G region in the upper portion of the cavity and ionic interactions between residues in the beta-sheet domain that reduce the width of the cavity. The structural differences exhibited by 3A4 and 3A5 suggest that the overlap of catalytic activities may reflect molecular flexibility that determines how alternative conformers fit into the different active site architectures of the two enzymes.

-	~~Authors~~:	+	The X-ray Crystal Structure of the Human Monooxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.,Hsu MH, Savas U, Johnson EF Mol Pharmacol. 2017 Nov 1. pii: mol.117.109744. doi: 10.1124/mol.117.109744. PMID:29093019<ref>PMID:29093019</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5veu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Unspecific monooxygenase]]
		+	[[Category: Hsu, M H]]
		+	[[Category: Johnson, E F]]
		+	[[Category: Complex]]
		+	[[Category: Cyp3a5]]
		+	[[Category: Cytochrome p450]]
		+	[[Category: Inhibitor]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
		+	[[Category: Ritonavir]]

OCA at 12:13, 27 April 2017

2017-04-27T12:13:34Z

←Older revision		Revision as of 12:13, 27 April 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5veu is ON HOLD	+	The entry 5veu is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5veu" [edit=sysop:move=sysop]

2017-04-12T09:59:23Z

Protected "5veu" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:59, 12 April 2017

OCA: New page: '''Unreleased structure''' The entry 5veu is ON HOLD Authors: Description: Category: Unreleased Structures

2017-04-12T09:59:21Z

New page: '''Unreleased structure''' The entry 5veu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5veu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]