5vga - Revision history

OCA at 10:14, 13 April 2022

2022-04-13T10:14:57Z

←Older revision		Revision as of 10:14, 13 April 2022
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	<StructureSection load='5vga' size='340' side='right'caption='[[5vga]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5vga' size='340' side='right'caption='[[5vga]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vga]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5VGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VGA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a6i\|2a6i]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2a6i\|2a6i]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5vga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vga OCA], [~~http~~://pdbe.org/5vga PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vga RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vga PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vga ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vga OCA], [https://pdbe.org/5vga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vga RCSB], [https://www.ebi.ac.uk/pdbsum/5vga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vga ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:36, 30 September 2020

2020-09-30T08:36:28Z

←Older revision		Revision as of 08:36, 30 September 2020
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	==Alternative model for Fab 36-65==		==Alternative model for Fab 36-65==
-	<StructureSection load='5vga' size='340' side='right' caption='[[5vga]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5vga' size='340' side='right'caption='[[5vga]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGA OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VGA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VGA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a6i\|2a6i]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a6i\|2a6i]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vga OCA], [http://pdbe.org/5vga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vga RCSB], [http://www.ebi.ac.uk/pdbsum/5vga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vga ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vga OCA], [http://pdbe.org/5vga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vga RCSB], [http://www.ebi.ac.uk/pdbsum/5vga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vga ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Dauter, Z]]		[[Category: Dauter, Z]]

OCA at 07:15, 6 December 2017

2017-12-06T07:15:11Z

←Older revision		Revision as of 07:15, 6 December 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vga is ~~ON HOLD~~	+	==Alternative model for Fab 36-65==
		+	<StructureSection load='5vga' size='340' side='right' caption='[[5vga]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5vga]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VGA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2a6i\|2a6i]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vga OCA], [http://pdbe.org/5vga PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vga RCSB], [http://www.ebi.ac.uk/pdbsum/5vga PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vga ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Correlation between the promiscuity of the primary antibody response and conformational flexibility in a germline antibody was addressed by using germline antibody 36-65. Crystallographic analyses of the 36-65 Fab with three independent dodecapeptides provided mechanistic insights into the generation of antibody diversity. While four antigen-free Fab molecules provided a quantitative description of the conformational repertoire of the antibody CDRs, three Fab molecules bound to structurally diverse peptide epitopes exhibited a common paratope conformation. Each peptide revealed spatially different footprints within the antigen-combining site. However, a conformation-specific lock involving two shared residues, which were also associated with hapten binding, was discernible. Unlike the hapten, the peptides interacted with residues that undergo somatic mutations, suggesting a possible mechanism for excluding "nonspecific" antigens during affinity maturation. The observed multiple binding modes of diverse epitopes within a common paratope conformation of a germline antibody reveal a simple, yet elegant, mechanism for expanding the primary antibody repertoire.

-	~~Authors~~:	+	Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response.,Sethi DK, Agarwal A, Manivel V, Rao KV, Salunke DM Immunity. 2006 Apr;24(4):429-38. PMID:16618601<ref>PMID:16618601</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5vga" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Mus musculus]]
		+	[[Category: Dauter, Z]]
		+	[[Category: Jaskolski, M]]
		+	[[Category: Minor, W]]
		+	[[Category: Porebski, P J]]
		+	[[Category: Pozharski, E]]
		+	[[Category: Rupp, B]]
		+	[[Category: Stanfield, R L]]
		+	[[Category: Weichenberger, C X]]
		+	[[Category: Wlodawer, A]]
		+	[[Category: Germline antibody anti-arsonate]]
		+	[[Category: Immune system]]

OCA: Protected "5vga" [edit=sysop:move=sysop]

2017-04-19T11:24:28Z

Protected "5vga" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 19 April 2017

OCA: New page: '''Unreleased structure''' The entry 5vga is ON HOLD Authors: Description: Category: Unreleased Structures

2017-04-19T11:24:27Z

New page: '''Unreleased structure''' The entry 5vga is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vga is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]