5vpc - Revision history

OCA at 13:54, 4 October 2023

2023-10-04T13:54:28Z

←Older revision		Revision as of 13:54, 4 October 2023
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	<StructureSection load='5vpc' size='340' side='right'caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5vpc' size='340' side='right'caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VPC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VPC FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=CL:CHLORIDE+ION'>CL</scene~~>, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.498Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5vpa\|5vpa]], [[5vpd\|5vpd]], [[5vpe\|5vpe]], [[5vpf\|5vpf]], [[5vpb\|5vpb]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">FOSB, G0S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=9606 HUMAN]), JUND ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpc OCA], [https://pdbe.org/5vpc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vpc RCSB], [https://www.ebi.ac.uk/pdbsum/5vpc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpc ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpc OCA], [~~http~~://pdbe.org/5vpc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vpc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vpc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpc ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN]] FosB interacts with Jun proteins enhancing their DNA binding activity. ~~[[http://www.uniprot.org/uniprot/JUND_HUMAN JUND_HUMAN]] Transcription factor binding AP-1 sites.<ref>PMID:9989505</ref>~~	+	[https://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN] FosB interacts with Jun proteins enhancing their DNA binding activity.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Machius~~, M C~~]]	+	[[Category: Machius MC]]
-	[[Category: Rudenko, G]]	+	[[Category: Rudenko G]]
-	[[Category: Yin, Z]]	+	[[Category: Yin Z]]
-	~~[[Category: Activator protein-1]]~~	+
-	~~[[Category: Basic leucine zipper]]~~	+
-	~~[[Category: Bzip]]~~	+
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Fo]]~~	+
-	~~[[Category: Jun]]~~	+
-	~~[[Category: Redox switch]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor~~]]	+

OCA at 17:21, 11 December 2019

2019-12-11T17:21:04Z

←Older revision		Revision as of 17:21, 11 December 2019
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	==Transcription factor FosB/JunD bZIP domain in its oxidized form, type-II crystal==		==Transcription factor FosB/JunD bZIP domain in its oxidized form, type-II crystal==
-	<StructureSection load='5vpc' size='340' side='right' caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5vpc' size='340' side='right'caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPC FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPC FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5vpc" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vpc" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Metallothiol transferase FosB\|Metallothiol transferase FosB]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Machius, M C]]		[[Category: Machius, M C]]
	[[Category: Rudenko, G]]		[[Category: Rudenko, G]]

OCA at 10:15, 15 November 2017

2017-11-15T10:15:16Z

←Older revision		Revision as of 10:15, 15 November 2017
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	<StructureSection load='5vpc' size='340' side='right' caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5vpc' size='340' side='right' caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vpa\|5vpa]], [[5vpd\|5vpd]], [[5vpe\|5vpe]], [[5vpf\|5vpf]], [[5vpb\|5vpb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vpa\|5vpa]], [[5vpd\|5vpd]], [[5vpe\|5vpe]], [[5vpf\|5vpf]], [[5vpb\|5vpb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FOSB, G0S3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), JUND ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpc OCA], [http://pdbe.org/5vpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vpc RCSB], [http://www.ebi.ac.uk/pdbsum/5vpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpc OCA], [http://pdbe.org/5vpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vpc RCSB], [http://www.ebi.ac.uk/pdbsum/5vpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpc ProSAT]</span></td></tr>
	</table>		</table>
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Machius, M C]]		[[Category: Machius, M C]]
	[[Category: Rudenko, G]]		[[Category: Rudenko, G]]

OCA at 06:57, 18 October 2017

2017-10-18T06:57:58Z

←Older revision		Revision as of 06:57, 18 October 2017
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN]] FosB interacts with Jun proteins enhancing their DNA binding activity. [[http://www.uniprot.org/uniprot/JUND_HUMAN JUND_HUMAN]] Transcription factor binding AP-1 sites.<ref>PMID:9989505</ref>		[[http://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN]] FosB interacts with Jun proteins enhancing their DNA binding activity. [[http://www.uniprot.org/uniprot/JUND_HUMAN JUND_HUMAN]] Transcription factor binding AP-1 sites.<ref>PMID:9989505</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The transcription factor, activator protein-1 (AP-1), binds to cognate DNA under redox control; yet, the underlying mechanism has remained enigmatic. A series of crystal structures of the AP-1 FosB/JunD bZIP domains reveal ordered DNA-binding regions in both FosB and JunD even in absence DNA. However, while JunD is competent to bind DNA, the FosB bZIP domain must undergo a large conformational rearrangement that is controlled by a 'redox switch' centered on an inter-molecular disulfide bond. Solution studies confirm that FosB/JunD cannot undergo structural transition and bind DNA when the redox-switch is in the 'OFF' state, and show that the mid-point redox potential of the redox switch affords it sensitivity to cellular redox homeostasis. The molecular and structural studies presented here thus reveal the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for therapeutic interventions targeting AP-1 proteins.
		+
		+	Activator Protein-1: redox switch controlling structure and DNA-binding.,Yin Z, Machius M, Nestler EJ, Rudenko G Nucleic Acids Res. 2017 Sep 7. doi: 10.1093/nar/gkx795. PMID:28981703<ref>PMID:28981703</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5vpc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:44, 13 September 2017

2017-09-13T09:44:05Z

←Older revision		Revision as of 09:44, 13 September 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vpc is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Transcription factor FosB/JunD bZIP domain in its oxidized form, type-II crystal==
-		+	<StructureSection load='5vpc' size='340' side='right' caption='[[5vpc]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vpc]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VPC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VPC FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vpa\|5vpa]], [[5vpd\|5vpd]], [[5vpe\|5vpe]], [[5vpf\|5vpf]], [[5vpb\|5vpb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vpc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vpc OCA], [http://pdbe.org/5vpc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vpc RCSB], [http://www.ebi.ac.uk/pdbsum/5vpc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vpc ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FOSB_HUMAN FOSB_HUMAN]] FosB interacts with Jun proteins enhancing their DNA binding activity. [[http://www.uniprot.org/uniprot/JUND_HUMAN JUND_HUMAN]] Transcription factor binding AP-1 sites.<ref>PMID:9989505</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Machius, M C]]
		+	[[Category: Rudenko, G]]
		+	[[Category: Yin, Z]]
		+	[[Category: Activator protein-1]]
		+	[[Category: Basic leucine zipper]]
		+	[[Category: Bzip]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Dna-binding protein]]
		+	[[Category: Fo]]
		+	[[Category: Jun]]
		+	[[Category: Redox switch]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor]]

OCA at 14:04, 17 May 2017

2017-05-17T14:04:46Z

←Older revision		Revision as of 14:04, 17 May 2017
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5vpc is ON HOLD	+	The entry 5vpc is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5vpc" [edit=sysop:move=sysop]

2017-05-10T11:18:23Z

Protected "5vpc" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:18, 10 May 2017

OCA: New page: '''Unreleased structure''' The entry 5vpc is ON HOLD Authors: Description: Category: Unreleased Structures

2017-05-10T11:18:21Z

New page: '''Unreleased structure''' The entry 5vpc is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vpc is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]