5vx1 - Revision history

OCA at 14:12, 13 March 2024

2024-03-13T14:12:43Z

←Older revision		Revision as of 14:12, 13 March 2024
Line 3:		Line 3:
	<StructureSection load='5vx1' size='340' side='right'caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='5vx1' size='340' side='right'caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5vwv\|5vwv]], [[5vww\|5vww]], [[5vwx\|5vwx]], [[5vwy\|5vwy]], [[5vwz\|5vwz]], [[5vx0\|5vx0]], [[5vx2\|5vx2]], [[5vx3\|5vx3]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.224Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">BAK1, BAK, BCL2L7, CDN1 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx1 OCA], [https://pdbe.org/5vx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vx1 RCSB], [https://www.ebi.ac.uk/pdbsum/5vx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5vx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx1 OCA], [~~http~~://pdbe.org/5vx1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5vx1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5vx1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>	+	[https://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
-	~~<div style="background-color:#fffaf0;">~~	+
-	~~== Publication Abstract from PubMed ==~~	+
-	Certain BH3-only proteins transiently bind and activate Bak and Bax, initiating their oligomerization and the permeabilization of the mitochondrial outer membrane, a pivotal step in the mitochondrial pathway to apoptosis. Here we describe the first crystal structures of an activator BH3 peptide bound to Bak and illustrate their use in the design of BH3 derivatives capable of inhibiting human Bak on mitochondria. These BH3 derivatives compete for the activation site at the canonical groove, are the first engineered inhibitors of Bak activation, and support the role of key conformational transitions associated with Bak activation.	+
-		+
-	Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.,Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. PMID:29149594<ref>PMID:29149594</ref>	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~	+
-	~~</div>~~	+
-	~~<div class="pdbe-citations 5vx1" style="background-color:#fffaf0;"></div~~>	+

	==See Also==		==See Also==
Line 26:		Line 16:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Brouwer~~, J M~~]]	+	[[Category: Brouwer JM]]
-	[[Category: Colman~~, P M~~]]	+	[[Category: Colman PM]]
-	[[Category: Czabotar~~, P E]]~~	+	[[Category: Czabotar PE]]
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Bcl-2 family]]~~	+
-	~~[[Category: Mutant~~]]	+

OCA at 08:28, 8 January 2020

2020-01-08T08:28:15Z

←Older revision		Revision as of 08:28, 8 January 2020
Line 1:		Line 1:

	==Bak L100A==		==Bak L100A==
-	<StructureSection load='5vx1' size='340' side='right' caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>	+	<StructureSection load='5vx1' size='340' side='right'caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5vx1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5vx1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Brouwer, J M]]		[[Category: Brouwer, J M]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]

OCA at 07:40, 29 November 2017

2017-11-29T07:40:14Z

←Older revision		Revision as of 07:40, 29 November 2017
Line 3:		Line 3:
	<StructureSection load='5vx1' size='340' side='right' caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>		<StructureSection load='5vx1' size='340' side='right' caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vwv\|5vwv]], [[5vww\|5vww]], [[5vwx\|5vwx]], [[5vwy\|5vwy]], [[5vwz\|5vwz]], [[5vx0\|5vx0]], [[5vx2\|5vx2]], [[5vx3\|5vx3]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vwv\|5vwv]], [[5vww\|5vww]], [[5vwx\|5vwx]], [[5vwy\|5vwy]], [[5vwz\|5vwz]], [[5vx0\|5vx0]], [[5vx2\|5vx2]], [[5vx3\|5vx3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BAK1, BAK, BCL2L7, CDN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx1 OCA], [http://pdbe.org/5vx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx1 OCA], [http://pdbe.org/5vx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>		[[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Certain BH3-only proteins transiently bind and activate Bak and Bax, initiating their oligomerization and the permeabilization of the mitochondrial outer membrane, a pivotal step in the mitochondrial pathway to apoptosis. Here we describe the first crystal structures of an activator BH3 peptide bound to Bak and illustrate their use in the design of BH3 derivatives capable of inhibiting human Bak on mitochondria. These BH3 derivatives compete for the activation site at the canonical groove, are the first engineered inhibitors of Bak activation, and support the role of key conformational transitions associated with Bak activation.
		+
		+	Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design.,Brouwer JM, Lan P, Cowan AD, Bernardini JP, Birkinshaw RW, van Delft MF, Sleebs BE, Robin AY, Wardak A, Tan IK, Reljic B, Lee EF, Fairlie WD, Call MJ, Smith BJ, Dewson G, Lessene G, Colman PM, Czabotar PE Mol Cell. 2017 Nov 16;68(4):659-672.e9. doi: 10.1016/j.molcel.2017.11.001. PMID:29149594<ref>PMID:29149594</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5vx1" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Brouwer, J M]]		[[Category: Brouwer, J M]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]

OCA at 07:34, 15 November 2017

2017-11-15T07:34:40Z

←Older revision		Revision as of 07:34, 15 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5vx1 is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Bak L100A==
-		+	<StructureSection load='5vx1' size='340' side='right' caption='[[5vx1]], [[Resolution\|resolution]] 1.22Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5vx1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VX1 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5vwv\|5vwv]], [[5vww\|5vww]], [[5vwx\|5vwx]], [[5vwy\|5vwy]], [[5vwz\|5vwz]], [[5vx0\|5vx0]], [[5vx2\|5vx2]], [[5vx3\|5vx3]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vx1 OCA], [http://pdbe.org/5vx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5vx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vx1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Brouwer, J M]]
		+	[[Category: Colman, P M]]
		+	[[Category: Czabotar, P E]]
		+	[[Category: Apoptosis]]
		+	[[Category: Bcl-2 family]]
		+	[[Category: Mutant]]

OCA: Protected "5vx1" [edit=sysop:move=sysop]

2017-09-27T14:15:32Z

Protected "5vx1" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:15, 27 September 2017

OCA: New page: '''Unreleased structure''' The entry 5vx1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2017-09-27T14:15:31Z

New page: '''Unreleased structure''' The entry 5vx1 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5vx1 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]